Clinical trials: Surgery, Dental
Acute Postoperative Pain, Dental Pain
A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction
The primary objective of this trial is to assess the safety and tolerability of single, ascending doses of CYT-1010 in healthy male and female volunteers and in the treatment of acute postoperative pain after third molar…
- Trial name
- NCT07905105
- Testing
- CYT-1010
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cytogel Pharma, LLC
Dental Pain
Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Accessing the efficacy and safety of pregabalin when used alone and in combo with acetaminophen in a dental pain model. To test whether pre-operative dose of pregabalin increases the time to significant post-operative pain (NRS ≥…
- Trial name
- NVK009-0001 (NCT03652818)
- Testing
- Pre-Op pregabalin, Post-Op pregabalin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Acute Pain
Preventive Treatment of Pain After Dental Implant Surgery
The objective of this prospective randomized double-blind study was to evaluate the effects of the preoperative administration of dexketoprofen trometamol (DKT) on the pain perceived by patients after oral surgery for implant…
- Trial name
- UMU (NCT03107338)
- Testing
- DEXKETOPROFEN TROMETAMOL
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Dental Implant Placement
Implant Placement in Combination With Connective Tissue Grafting
Suitable subjects who were in need of implant placement were randomised between two groups; Group-A (NA=23) received crestal implant placement.
- Trial name
- CTG_implant (NCT03728283)
- Testing
- implant placement in combination with connective tissue grafting, Implant placement
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Dental Implant
The Accuracy of s-CAIS Compared With c-LIS
To compare the static computer-aided implant surgery (s-CAIS) and conventional laboratory-guided implant surgery (c-LIS) in terms of accuracy for single tooth replacement in posterior areas.
- Trial name
- NCT05361226
- Testing
- Accuracy measurement
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dental, Dental Extraction
Insomnia and Post-Dental Surgery Pain: A Prospective Study
The purpose of this prospective observational study is to evaluate the relationship between preoperative sleep disturbances-specifically insomnia-and postoperative pain intensity following oral surgical procedures.
- Conditions
- Dental, Dental Extraction, Insomnia
- Trial name
- INDOLC (NCT07712432)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dental Pain and Sensation Disorders
Musicotherapy in Reducing Peroperative Anxiety and Post-surgical Pain in Dental Care
The main purpose of MUSANX study is to highlight analgesic effectiveness of musicotherapy in post-surgical periodontal and implant; and to measure its per-operative anxiolytic effectiveness
- Trial name
- MUSANX (NCT03925571)
- Testing
- musicotherapy
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Nantes University Hospital
Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Immediate Dental Implant Placement
Influence of Provisional Restoration Type on Outcomes of Immediate Implant Placement and Loading
A randomized clinical trial comparing 3D-printed resin and CAD/CAM-milled PMMA provisional restorations used for immediate loading of fully digitally guided immediate implants.
- Conditions
- Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Immediate Dental Implant Placement, Immediate Loading, Provisional Restoration
- Trial name
- PRODIGI (NCT07700771)
- Testing
- 3D-Printed Resin Provisional Crown, CAD/CAM-Milled PMMA Provisional Crown
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Dental Implants, Surgery, Computers
Dynamic Navigation-Assisted Dental Implant Placement
Placement of dental implants via the freehand approach may result in damage to the surrounding critical anatomy of undiscordant prosthetic position.
- Trial name
- NCT03471208
- Testing
- Dynamic Navigation Assisted Implant Surgery, Freehand Implant Surgery
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Periapical Periodontitis, Pulpitis
Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments
Background: Pulpitis and apical periodontitis are inflammatory conditions of the dental pulp and periapical tissues, primarily caused by microbial invasion.
- Trial name
- CR-ET (NCT07418840)
- Testing
- Root canal treatment and non surgical endodontic retreatment
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Edentulous Mouth, Complete Edentulism
Mandibular Overdentures Retained by Mini Implants: a Clinical Trial Comparing Different Surgical and Loading Protocols
This study aims to test the combined effects of different loading protocols and surgical approaches on clinical and patient-reported outcome measures (PROMs) following the use of four mini implants for mandibular overdenture…
- Trial name
- SMIS (NCT04760457)
- Testing
- Implant placement with flapped surgery, Implant placement with flapless surgery, Implant immediate loading
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Universidade Federal de Goias
Guided Surgery Accuracy, Dental Implant Failed
Sleeves Versus Sleeveless Template
To compare virtual planning accuracy of computer-assisted template-based implant placement using CAD/CAM stereolithographic surgical templates with or without metallic sleeves.Furthermore to compare open versus closed holes in…
- Conditions
- Guided Surgery Accuracy, Dental Implant Failed, Complications
- Trial name
- NCT03641365
- Testing
- Test group, Control group
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Osstem AIC
Palatal Donor Site Wound Healing, Platelet Rich Fibrin
Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.
The goal of this clinical trial (2-arm) is to determine if the application of platelet rich fibrin (PRF) to palatal donor sites influence patients quality of life, sleep efficiency, and healing following mucogingival surgery.
- Conditions
- Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain
- Trial name
- NCT07637838
- Testing
- Platelet rich fibrin, Control Group: collagen matrices or oxidized cellulose membrane
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- 59th Medical Wing
Peri-implantitis
Peri-Implantitis Surgical Treatment an RCT Study
The purpose of this experimental study in humans is to evaluate and compare, the regenerative therapy for the treatment of peri-implantitis using different bone substitutes and absorbable membranes with surgical therapy without…
- Trial name
- NCT02575274
- Testing
- Surgical flaps
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Mr. Sergio Diniz Ferreira
Suture Adverse Reaction, Suture; Complications, Mechanical
Properties of Absorbable and Nonabsorbable Suture Material in Dental Surgery
A suture is a biomedical device that is made of natural or synthetic materials. Sutures are used to close tissue surfaces until wounds heal and regain their ability to withstand normal stresses.
- Conditions
- Suture Adverse Reaction, Suture; Complications, Mechanical, Suture Failure During Surgical Operation, Suture Related Complication
- Trial name
- NCT04234308
- Testing
- Polyglycolic Acid, Catgut, Polytetrafluoroethylene
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad Científica del Sur
Dental Implant, Computer-assisted
Accuracy of Static Computer-assisted Implant Surgery in Distal Free-end Scenarios
Technological advances have influenced the approach to implant treatment. One of the fields presently experiencing rapid development is static computer-assisted guided surgery (sCAIS), which allows transfer of the virtual implant…
- Trial name
- NCT06404385
- Testing
- Static computer-assisted guided surgery with analogic guide, Static computer-assisted guided surgery with CAD-CAM surgical guide
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Dental Pain
Methodological Validation of Ibuprofen Verses Placebo for Post Operative Pain After Third Molar Extraction Surgery
This is a single center placebo controlled, prospective, randomized study on healthy adults undergoing third molar surgery.
- Trial name
- NCT02096926
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
Dental Surgery
Evaluation of a Non-cross-linked Porcine Acellular Dermal Matrix Used in Dental Surgery
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS Dental membrane used in dental surgery and to identify emerging risks in comparison to clinical data related to…
- Trial name
- NCT05435976
- Testing
- CELLIS Dental (Porcine Acellular Dermal Matrix, PADM)
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- Meccellis Biotech
Alveolar Bone Loss, Maxillary Sinus Bone Loss
Anti-HLA Antibodies After Bone Regeneration Surgery
This study evaluates the occurrence of anti-human leukocyte antigen (anti-HLA) antibodies following bone regeneration procedures performed prior to dental implant therapy.
- Trial name
- Anti-HLA Bone (NCT07474857)
- Testing
- Xenogeneic Bone Graft, Allogeneic Bone Graft, Low-Level Laser Therapy
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw