Clinical trials: Surgery, Thoracic
Thoracic Surgery, Cardiopulmonary Bypass
Cerebral Autoregulation Monitoring During Cardiac Surgery
Neurological complications from cardiac surgery are an important source of operative mortality, prolonged hospitalization, health care expenditure, and impaired quality of life.
- Trial name
- NCT00981474
- Testing
- blood pressure maintenance based on cerebral blood flow autoregulation measurement, Control group
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Northwestern University
Anesthesia, Nerve Block
Comparison of the Effect of Preoperative and Postoperative ESP and PVB on Postoperative Pain in VATS
The aim of this prospective controlled randomised clinical trial was to identify the analgesic method that is more effective than two different regional analgesia techniques routinely used for pain control after video-assisted…
- Conditions
- Anesthesia, Nerve Block, Pain, Postoperative, Thoracic Surgery, Video Assisted
- Trial name
- NCT06488014
- Testing
- Erector spina plan block (ESP), Paravertebral block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara University
Pulmonary Function, Incentive Spirometry
Digital Incentive Spirometry Adherence
This single-arm proof-of-concept research study aims to assess the effect of a digital incentive spirometer (IS) device and a companion mobile-based app on incentive spirometry adherence in patients post-surgery.
- Conditions
- Pulmonary Function, Incentive Spirometry, Patient Adherence, Lung Resection
- Trial name
- NCT06629454
- Testing
- Adherence to digital incentive spirometer in the postop period after major chest surgery.
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Pennsylvania
Thoracic Surgery
Local Anesthetic as Single Shot Versus Catheter in Patients Undergoing Video Assisted Thoracoscopic Surgery
The purpose of this research is to compare a single shot long acting local anesthetic to catheter infusion of local anesthetic in patients undergoing video assisted thoracoscopic (VAT) surgery.
- Trial name
- NCT04559347
- Testing
- Liposomal Bupivacaine (EXPAREL®)/Bupivacaine, Ropivacaine (0.5% bolus followed by 0.2% infusion)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Poovendran Saththasivam
Thoracic Surgery
Improving Quality of Life After Thoracic Surgery Using Patient-Reported Outcomes
This study is designed to test if patient-reported outcomes with automated reporting to clinicians for remote monitoring of postoperative symptoms is feasible and improves quality of life, health outcomes, and service utilization…
- Trial name
- NCT04342260
- Testing
- Active Monitoring, Passive Monitoring
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Non-Cardiac/ Non-Thoracic Surgery, Abdominal Surgery
Assisted Fluid Management IDE Study
The primary objective of this study is to evaluate the performance of the Acumen™ Assisted Fluid Management (AFM) Feature in its ability to predict a subject's fluid responsiveness.
- Conditions
- Non-Cardiac/ Non-Thoracic Surgery, Abdominal Surgery, Pelvic Surgery, Major Peripheral Vascular Surgery
- Trial name
- AFM (NCT03469570)
- Testing
- EV1000 Clinical Platform with Assisted Fluid Management (AFM) Feature
- Where
- 10 sites in United States
- Volunteers
- 330 people
- Sponsor
- Edwards Lifesciences
Cardiovascular Diseases, Thoracic Diseases
Respiratory Strength Training in Cardiac Surgical Patients
Swallowing difficulty (dysphagia) is a common postoperative complication in patients who undergo cardiac surgical procedures. Postoperative dysphagia in cardiac surgical patients is associated with negative health-related…
- Conditions
- Cardiovascular Diseases, Thoracic Diseases, Surgery, Surgery--Complications
- Trial name
- NCT04887415
- Testing
- Respiratory Strength Training (RST) Program
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Older Adults, Anxiety
Behavioral Activation and Medication Optimization for Perioperative Mental Health Feasibility Study
Inadequate management of preoperative mental health disorders often contributes to poor postoperative outcomes, including increased rates of readmission, delirium, falls, and mortality.
- Conditions
- Older Adults, Anxiety, Depression, Cardiac Surgery
- Trial name
- NCT05110690
- Testing
- Behavioral Activation, Medication Optimization
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation, Thoracic Surgery
Colchicine For Prevention of Perioperative Atrial Fibrillation in Patients Undergoing Thoracic Surgery Pilot Study
The purpose of this pilot study is to determine the feasibility of comparing colchicine to placebo for the prevention of new onset atrial fibrillation in patients undergoing general thoracic surgery and establish the foundation…
- Trial name
- COP-AF Pilot (NCT01985425)
- Testing
- Colchicine 0.6 mg
- Where
- 2 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Pulmonary Embolism, Thoracic Surgery
Chemoprophylaxis Plus Early Ambulation
Pulmonary embolism (PE) can be a devastating postoperative complication and the leading cause of mortality after thoracic surgery.
- Trial name
- NCT03862755
- Testing
- Chemoprophylaxis with Low Molecular Weight Heparin (LMWH)
- Where
- China
- Volunteers
- 581 people
- Sponsor
- Shen Lei
Thoracic Surgery, One-lung Ventilation
Intraoperative Neuromuscular Blockade and Postoperative Atelectasis
During one-lung ventilation in thoracic surgery, the intensity of neuromuscular blockade may change the compliance and resistance of ventilated lung, thereby affecting postoperative atelectasis.
- Trial name
- NCT03503565
- Testing
- intraoperative neuromuscular blockade
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Coronary Artery Bypass Graft, Non-cardiac Thoracic Surgery
Pilot Testing a Home-Based Rehabilitation Intervention Designed to Improve Outcomes of Frail Veterans Following Cardiothoracic Surgery
Frail Veterans are at increased risk for poor surgical outcomes, and as the Veteran population grows older and more frail, there is a critical need to identify effective strategies for reducing surgical risks for these patients.
- Conditions
- Coronary Artery Bypass Graft, Non-cardiac Thoracic Surgery, Frailty
- Trial name
- NCT03299101
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Office of Research and Development
Thoracic Surgery
Study of Atorvastatin Versus Placebo to Reduce Cardiopulmonary Complications After Thoracic Surgery
This study will compare atorvastatin (Lipitor) with a placebo (inactive pill) to see if this drug reduces heart rhythm abnormalities (arrhythmias) or lung inflammation after thoracic surgery.
- Trial name
- NCT00375518
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Abdominal Surgery, Thoracic Surgery
Parent/Nurse Controlled Analgesia in the Neonatal Intensive Care Unit
The aim of this study is to examine the safety and effectiveness of 2 morphine delivery systems for post-surgical neonates. The investigators hypothesize that this study will be feasible to conduct, and that neonates receiving…
- Trial name
- PNCA (NCT01823497)
- Testing
- Morphine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Medical College of Wisconsin
Lung Collapse, One-Lung Ventilation
Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung isolation technique and one-lung ventilation (OLV) are the mainstays of thoracic anesthesia. Two principal lung isolation techniques are mainly use by clinicians, the double lumen tubes (DLT) and the bronchial blockers (BB).
- Conditions
- Lung Collapse, One-Lung Ventilation, Thoracic Surgery, Video-Assisted
- Trial name
- PLC-OLV (NCT02919267)
- Testing
- Double lumen tube, Bronchial blocker
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
Lung Diseases, Ultrasonography
Lung Ultrasonography vs Fiberoptic Bronchoscopy for Aiding Lung Collapse in Patient Using Double Lumen Tube
The study contains the result from a comparison of diagnostic outcomes about lung collapse by using lung ultrasonography as a new diagnostic test compares to fiberoptic bronchoscopy as the standard test.
- Conditions
- Lung Diseases, Ultrasonography, Fiberoptic Bronchoscopy, One Lung Ventilation
- Trial name
- NCT03314519
- Testing
- Lung ultrasonography by experienced anaesthesiologist, Fiberoptic bronchoscopy for double lumen tube's position
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Single Lung Ventilation, Thoracic Surgery
Double-lumen Tubes (DLT) - Health Economic Study
The aim of this study is to make a health economic evaluation comparing novice physicians use of VivaSight double-lumen tube and a conventional double-lumen tube for single-lung ventilation during thoracic surgery at a teaching…
- Conditions
- Single Lung Ventilation, Thoracic Surgery, Anesthesia, Cost-effectiveness
- Trial name
- NCT03817879
- Testing
- VivaSight double-lumen tube for single-lung ventilation, Conventional double-lument tube for single-lung ventilation
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Ambu A/S
Vitamin D Deficiency, Thoracic Surgery
Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level
Our research group has shown that almost all children with congenital heart disease (CHD) are vitamin D deficient following heart surgery.
- Conditions
- Vitamin D Deficiency, Thoracic Surgery, Pediatric Disorders, Heart Defects, Congenital
- Trial name
- HICCUPS 2 (NCT01838447)
- Testing
- Cholecalciferol
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Children's Hospital of Eastern Ontario
Lung Neoplasm, Thoracic Surgery, Video-Assisted
Application of 3D Printing Technique in Small Pulmonary Nodule Localization
The trial is to evaluate the efficacy and safety of three-dimensional printed navigational template in the clinical application of small peripheral lung nodule localization.
- Trial name
- NCT02952261
- Testing
- template-guided localization, CT-guided localization
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chang Chen
Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia
The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction
It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.
- Conditions
- Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia, Block Level, Gastrointestinal Surgery
- Trial name
- NCT02135016
- Testing
- 1% lidocaine, 2% lidocaine, 0.9% normal saline
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University