Clinical trials: Surgery (Cardiac)
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Myocardial Injury, Non-cardiac Surgery
Hemodynamics and Myocardial Injury After Non-cardiac Surgery
The incidence of myocardial injury after non-cardiac surgery (MINS) is approximately 12-15% and is associated with an increased risk of 30-day mortality, 1-year mortality, and 2-year major vascular events.
- Conditions
- Myocardial Injury, Non-cardiac Surgery, Complication,Postoperative, High-sensitivity Troponin
- Trial name
- MINS (NCT05188001)
- Testing
- Not an Interventional Study
- Where
- Canada
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiac Surgery
Upper Extremity Exercises With and Without Deep Breathing After Cardiac Surgery
This randomized 2×2 crossover trial aims to evaluate the effects of upper extremity range of motion exercises performed with and without deep breathing on respiratory parameters in patients after open cardiac surgery.
- Trial name
- ROM-DB (NCT07627009)
- Testing
- Deep Breathing Exercise, Upper Extremity ROM Exercise Combined with Deep Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Myocardial Infarction Postoperative, Myocardial Injury
Preoperative BNP: Epidemiological Patterns, Management Strategies and Cost Analysis of Care
Recently, the use of preoperative BNP as a preoperative risk stratifcation tool was added to the Canadian Cardiovascular Society (CCS) guidelines (4) on perioperative cardiac risk assessment and management for patients who…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Death, Cardiac
- Trial name
- NCT04077294
- Testing
- Cardiac risk stratification using preoperative BNP measurement, followed by postoperative cardiac monitoring, Use of traditional perioperative cardiac risk stratification only
- Where
- Canada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Cardioplegia Solution Adverse Reaction
Modified Del Nido Versus Custodiol Cardioplegia For Myocardial Protection In Cardiac Surgery.
Cardioplegia solutions have been considered as a corner stone for myocardial protection during cardiac surgery with cardiopulmonary bypass and cardiac arrest, it limits the metabolic activity and increases the capacity of the…
- Trial name
- NCT05221294
- Testing
- Modified Del Nido Versus Custodiol Cardioplegia
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Postoperative Complications
The Effect of Telephone Nursing Education and Counseling Services Given to Satisfaction Level and Self-Care Strength
In the post-discharge period, it is important to follow the patients from home by telephone and to provide the necessary nursing education and counseling services, increasing the self-care powers of the patients, increasing their…
- Trial name
- NCT05487638
- Testing
- Nursing Education and Counseling Service Provided to Patients by Video Calling on the Phone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Frailty in Adult Surgery
Functional Capacity Through HRV in Multimodal Rehabilitation for Adult Surgery
This prospective, observational cohort study investigates heart rate variability (HRV) monitoring using the Analgesia Nociception Index (ANI) monitor in adult patients undergoing major surgery within a multimodal rehabilitation…
- Trial name
- PreANI (NCT06436417)
- Testing
- Analgesia Nociception Index (ANI) Monitor, Trimodal Prehabilitation
- Where
- Spain
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Investigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon
Red Blood Cell Transfusion
The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery
The TheRAPy vanguard trial is a multicentre, multiple period randomized, cluster crossover vanguard trial testing the feasibility of a full-scale trial to evaluate whether a centre-based policy of routine use of RAP versus a…
- Trial name
- TheRAPy (NCT06230198)
- Testing
- retrograde autologous priming (RAP), Crystalloid priming
- Where
- 4 sites in Canada
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Stroke, Acute Coronary Syndrome
Factors Associated With Perioperative Outcomes in Non-emergency Surgery
This epidemiological study investigates the association of recent stroke, acute coronary syndrome or pneumonia and adverse perioperative outcomes following elective non-cardiac and cardiac surgery using routinely collected UK…
- Conditions
- Stroke, Acute Coronary Syndrome, Pneumonia
- Trial name
- NCT02455492
- Testing
- stroke or myocardial infarction or pneumonia
- Volunteers
- 266,436 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Abdominal Cancer, Blood Pressure
The Effect of Patient Position Changes on Advanced Cardiac Indices in Cancer Surgery
Esophageal Doppler Monitoring (Deltex CardioQ Esophageal Doppler Monitor, ODM) is used to manage patients' fluid therapy by non-invasively measuring continuous cardiac output with an esophageal probe.
- Conditions
- Abdominal Cancer, Blood Pressure, Cardiac Indices
- Trial name
- NCT06293391
- Testing
- cardiac indices in supine and trendelenburg position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Postoperative Cognitive Dysfunction, Cerebrovascular Accident
Neurological Outcome After Minimal Invasive Coronary Artery Bypass Graft
Primary objectives: Assessment of the incidence of postoperative cognitive dysfunction (POCD), cerebrovascular accident (CVA), and delirium after minimal invasive coronary artery bypass grafting (Endo-CABG).
- Conditions
- Postoperative Cognitive Dysfunction, Cerebrovascular Accident, Delirium
- Trial name
- NOMICS (NCT02979782)
- Testing
- Endo-CABG, PCI
- Where
- 2 sites in Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital