Clinical trials: Surgery Site Fistula
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum
Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula
Curative management of locally resectable invasive adenocarcinomas located in the cephalic region of the pancreas (pancreas, duodenum and ampulla of Vater) requires a pancreaticoduodenectomy followed by adjuvant chemotherapy.
- Conditions
- Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum, Ampullary Adenocarcinoma
- Trial name
- TPIAT-01 (NCT05116072)
- Testing
- total pancreatectomy, intraportal islet autotransplantation
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Pancreatic Fistula, Whipple Operation
Identifing Risk Factors for Pancreaticojejunostomy Leakage Following Pancreaticoduodenectomy
Pancreatic cancer is an aggresive type of cancer with poor mean survival rates despite improvements in chemotherapy regimens and advances in surgical techniques. Surgery is the only therapeutic option with an intend to treat.
- Conditions
- Pancreatic Fistula, Whipple Operation, Pancreaticoduodenectomy, POPF
- Trial name
- NCT04798560
- Testing
- Pancreaticoduodenectomy
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Dimitrios Vouros
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Surgery Site Fistula
A Modified Approach for the Closure of Oral Sinus Communications
The aim of this study is to describe a modified surgical approach for the closure of oral sinus communications, using a buccal trapezoidal flap combined with a connective pedicle flap rotated from the palate
- Trial name
- NCT04499144
- Testing
- modified buccal flap and subepithelial connective palatal flap
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Siena
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Tumors
Reduced Pancreatic Fistula Rate Following Pancreaticoduodenectomy: Trial on Pancreaticogastrostomy Versus Pancreaticojejunostomy
The incidence of complications after pancreaticoduodenectomy (PD) is around 50 %. The postoperative course after PD is strongly dependent of the occurrence of pancreatic fistula (POPF), which determines postoperative mortality…
- Trial name
- NCT00830778
- Testing
- Pancreaticojejunostomy, Pancreaticogastrostomy
- Where
- Belgium
- Volunteers
- 336 people
- Sponsor
- Baki Topal
Pancreas Cancer, Pancreatic Fistula
Validations of New cut-of for the Stratification of Postoperative Complications,Drains Management
Pancreatic fistula (PF) represents the Achille's heel of pancreatic surgery and is the main cause of postoperative morbidity since it can determine the onset of others complications such as abdominal abscesses, surgical wound…
- Trial name
- DALCUT (NCT04380506)
- Testing
- Surgical Drains Management
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- Campus Bio-Medico University
Postoperative Fistula
Teduglutide for Enterocutaneous Fistula (ECF)
The purpose of this study is to determine whether Teduglutide is safe and feasible to be given for the treatment of enterocutaneous fistula (ECF).
- Trial name
- NCT02889393
- Testing
- Teduglutide, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Daniel Dante Yeh
Pancreatic Cancer, Pancreatic Neoplasms
Monitoring of patIents With Microdialysis Following Pancreaticoduodenectomy
A pancreaticoduodenectomy is performed in patient with pancreatic cancer. The most common and serious complication is leakage between the intestine and the remnant pancreas after this procedure. It occurs in 20-30%.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Biliary Tract Cancer, Duodenal Cancer
- Trial name
- MINIMUM (NCT03631173)
- Testing
- Surgical og radiological intervention, antibiotics
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Oslo University Hospital
Surgical Wound Infection, Surgical Site Infection
Bacteriology of sUrGical Site INfection Following Surgery for Intestinal Failure
This is a prospective observational study of patients undergoing planned surgery for intestinal failure. The aims of the study are: To prospectively characterise preoperative bacterial populations amongst patients undergoing…
- Conditions
- Surgical Wound Infection, Surgical Site Infection, Bacteria Infection Mechanism, Intestinal Disease
- Trial name
- BUGS-IN-IF (NCT05234515)
- Testing
- Microbiology swab, Questionnaire
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- London North West Healthcare NHS Trust
Pancreas Cancer, Pancreas Neoplasm
Prognostic Factors in Periampullary Tumors and Cysts
The project aims at analysing prognostic and predictive factors involved in diagnostics and surgical treatment of cysts and tumors in the pancreas and periampullary region using both clinical data and blood and tissue samples for…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Cyst, Pancreatic Fistula
- Trial name
- NCT05155878
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Pancreatectomy, Pancreatic Surgery
PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery
This study examines a new blood test called ICIS, which may help detect infections earlier after pancreatic surgery. Patients will have routine blood samples taken during their hospital stay, with no extra procedures required.
- Conditions
- Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
- Trial name
- PAN-ICIS (NCT07248527)
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic
Abdomen Hernia
The Effects of Post-Operative Interventions on Surgical Site Occurrences in AWR
Randomized controlled trial to compare SSO's in abdominal wall reconstruction patients using Prevena, Prineo, and traditional incisional dressings.
- Trial name
- NCT04906408
- Testing
- Prevena, Prineo, Traditional
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Obesity, Obesity, Morbid
Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)
The global prevalence of obesity has prompted an increase in bariatric surgery, which is the only management strategy that provides long-term weight loss and improvement of obesity-related diseases.
- Conditions
- Obesity, Obesity, Morbid, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- ES-LCCE-UDFM (NCT06862479)
- Testing
- Endoscopic management of fistulas with stents or vacum therapy
- Where
- Portugal
- Volunteers
- 180 people
- Sponsor
- Unidade Local de Saúde Santa Maria
Pancreatic Cancer, Adult, Margin, Tumor-Free
Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
This study is aimed to evaluate difference of the 2 year recurrence free survival after pancreaticoduodenectomy for pancreatic cancer between artery-first approach and conventional procedure groups.
- Conditions
- Pancreatic Cancer, Adult, Margin, Tumor-Free, Surgery Site Fistula, Recurrence Tumor
- Trial name
- NCT04136522
- Testing
- conventional pancreaticoduodenectomy, total mesopancreas excision including superior mesenteric artery first approach
- Where
- South Korea
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Periampullary Carcinoma, Pancreatic Cancer
Reoperation After Pancreaticoduodenectomy
The aim of this study is to outline the incidence of early and late reoperation after PD, examine the risk factors for early surgical intervention and its impact on the surgical outcome, hospital stay, diseases recurrence and…
- Trial name
- NCT04387903
- Testing
- Surgical re-interventionafter pancreaticoduodenectomy
- Volunteers
- 1,000 people
- Sponsor
- Mansoura University
Pancreatic Neoplasms, Pancreatic Fistula
Preoperative EUS Elastography for Pancreatic Texture and POPF Prediction After PD
This prospective study evaluates whether preoperative endoscopic ultrasound elastography (EUS-E) can predict pancreatic texture during surgery and risk of postoperative pancreatic fistula (POPF) in 100 patients undergoing…
- Trial name
- EUS-E (NCT07139236)
- Testing
- Preoperative Endoscopic Ultrasound Elastography (EUS Elastography)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Fistula, Surgery Site Fistula
ERAS in Gastrointerstinal Fistulas.
An enterocutaneous fistula (ECF) poses a major surgical problem. The definitive surgical repair of persistent fistulas remains a surgical challenge with a high rate of re-fistulation and mortality, and the reasons for that is not…
- Trial name
- NCT04771832
- Testing
- ERAS
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Stanley Dudrick's Memorial Hospital
Pancreatic Cancer
Predicting Pancreatic Fistula After Pancreatic Surgery Using Preoperative Immunity
The goal of this observational study is to develop and validate a preoperative immunological signature for predicting postoperative pancreatic fistula (POPF) in adult patients undergoing pancreatic surgery for pancreatic cancer.
- Trial name
- NCT07827911
- Testing
- blood sampling
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Paoli-Calmettes
Abdominal Tumor, Intestinal Obstruction
Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients
The alpha2 agonist dexmedetomidine is a new sedative agent combined with the analgesic qualities and lack of respiratory depression.
- Conditions
- Abdominal Tumor, Intestinal Obstruction, Cirrhosis, Intestinal Fistula
- Trial name
- NCT01669044
- Testing
- dexmedetomidine, propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University