Clinical trials: Surgery Site Fistula
Postoperative Fistula, Complications of Surgical and Medical Care: General Terms
External Drainage Versus Internal Drainage of Pancreatic Duct With a Stent After Pancreaticoduodenectomy (EDIDPD)
Postoperative pancreatic fistula (POPF) and other surgical complications are common after pancreatoduodenectomy (PD) and POPF is a major complication.
- Trial name
- EDIDPD (NCT01634971)
- Testing
- Internal Drainage of Pancreatic Duct after pancreatomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreatic Fistula, Pancreatic Neoplasms
HYPAR Trial - Hydrocortisone vs. Pasireotide in Reducing Pancreatic Surgery Complications
Pancreatic resections carry a high risk for complications, especially pancreatic fistula. Both hydrocortisone and pasireotide have been shown to be effective in reducing complications in earlier RCTs.
- Trial name
- HYPAR (NCT02775227)
- Testing
- Hydrocortisone, Pasireotide
- Where
- Finland
- Volunteers
- 126 people
- Sponsor
- Helsinki University Central Hospital
Pancreatic Cancer, Surgery--Complications
ERAS Protocol in Pancreaticoduodenectomy and Total Pancreatectomy
In the study, the enhanced recovery after surgery (ERAS) program is applied to total pancreatectomy (TP) and low-risk pancreaticoduodenectomy (PD) patients identified by a small number of acinar cells in the cut edge of the…
- Conditions
- Pancreatic Cancer, Surgery--Complications, Pancreatic Fistula, Delayed Gastric Emptying
- Trial name
- NCT03757455
- Testing
- ERAS protocol preoperative actions, ERAS protocol intraoperative actions, ERAS protocol postoperative actions
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Tampere University Hospital
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate)
This study investigates the safety and efficacy of injecting N-butyl-2-cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the pancreaticojejunostomy (PJ)…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07132541)
- Testing
- Pancreatic parenchymal injection of N-butyl-2-cyanoacrylate(Histoacryl®)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Pancreas Neoplasm
Risk Factors for Postoperative Pancreatic Fistula Following Non-traumatic Pancreatic Surgery. Retrospective Observational Study.
Postoperative pancreatic fistula is a potentially fatal sequela with substantial morbidity and mortality. A retrospective observational study was conducted in the surgical unit of Zagazig university hospital .
- Trial name
- NCT05711433
- Testing
- pancreatic surgery
- Volunteers
- 347 people
- Sponsor
- Zagazig University
Pancreas Neoplasm, Stump
Routine Staple Line Reinforcement for Minimally Invasive Distal Pancreatectomy
Postoperative fistula is the major complications of distal pancreatectomies which prohibit patients' recovery. Previous studies have reported controversial results regarding the efficacy of pancreatic stump reinforcement methods.
- Conditions
- Pancreas Neoplasm, Stump, Surgery--Complications
- Trial name
- Double-Lock (NCT04663789)
- Testing
- reinforcement of the staple line, staple only
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Peking Union Medical College Hospital
Pancreas Cancer, Surgery-Complications
Relieving the Bile Ducts Prior to Pancreatoduodenectomy
The aim of this study was to assess the risk and complications after preoperative drainage of biliary obstruction in patients who underwent pancreatoduodenectomy.
- Conditions
- Pancreas Cancer, Surgery-Complications, Biliary Fistula
- Trial name
- NCT05434520
- Testing
- Preoperative biliary drainage (ERC og PTC-aided)
- Where
- Denmark
- Volunteers
- 722 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Larynx Cancer, Pharynx Cancer
Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy
This trial aims to determine if intra-operative use of human dehydrated amnion chorion allograft improves post-operative patient healing outcomes.
- Conditions
- Larynx Cancer, Pharynx Cancer, Pharyngocutaneous Fistula
- Trial name
- NCT03479463
- Testing
- Dehydrated human amnion/chorion membrane
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- MiMedx Group, Inc.
Postprocedural Gastric Stasis
Gastric Emptying After Infracolic or Supracolic Gastrojejunostomy Following Pancreaticoduodenectomy
Patients undergoing whipples pancreaticoduodenectomy tend to develop delayed gastric emptying. The study compares two types of anastamosis of stomach to jejunum (supracolic and infracolic) and compares whether it influences the…
- Trial name
- NCT01191138
- Testing
- Infracolic gastrojejunal anastamosis, Supracolic gastrojejunal anastamosis
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asian Institute of Gastroenterology, India
Postoperative Complications
Biliary Externalization After Pancreaticoduodenectomy
Postoperative pancreatic fistula(POPF) is the most common complication of pancreaticoduodenectomy (PD). Sometimes POPF is associated with biliary fistula(BF), or "mixed" fistula.
- Trial name
- NCT04654299
- Testing
- External biliary stent
- Volunteers
- 128 people
- Sponsor
- Universidad de Extremadura
Pancreatic Cancer, Pancreatic Fistula
Anastomotic Techniques in Pancreaticoduodenectomy
There are two principal ways of draining the remnant of the pancreas back into the intestine after removal of the head of the pancreas for cancer. This can be performed either to the jejunum or to the stomach.
- Trial name
- PG/PJ (NCT00855985)
- Testing
- type of anastomosis after pancreaticoduodenectomy
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Lakeshore Hospital
Meningioma, Tumor, Brain
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
- Conditions
- Meningioma, Tumor, Brain, Chiari Malformation, Vascular Malformation
- Trial name
- MiDura (NCT04189172)
- Where
- 4 sites in France, Germany
- Volunteers
- 328 people
- Sponsor
- Aesculap AG
Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis)
Intraoperative Paravertebral Block and Postoperative Complications
This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections, Respiratory Failure Without Hypercapnia
- Trial name
- IPVB and POCs (NCT07211529)
- Testing
- Paravertebral Block (PVB)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Pancreas; Fistula, Pancreas Cancer
Assessing Pancreatic Fistula Rates After Distal Pancreatectomy Using AEON Endostapler
This prospective, observational study evaluates the rate of postoperative pancreatic fistula (POPF) following distal pancreatectomy (DP) using the AEON™ Endostapler.
- Conditions
- Pancreas; Fistula, Pancreas Cancer, Pancreatic Disease, Surgery-Complications
- Trial name
- AEON-DP (NCT06764134)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital Heidelberg
Hypothyroidism; Surgery, Head and Neck Cancer
Wound Complications in Head and Neck Surgery
This is a prospective observational study evaluating wound complications following head and neck surgery. Patients undergoing major head and neck surgery will be included in the study.
- Conditions
- Hypothyroidism; Surgery, Head and Neck Cancer, Wound Heal, Laryngeal Cancer
- Trial name
- NCT03134976
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Pancreatic Carcinoma, Pancreatic Neoplasm
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula
This phase III trial compares the effect of using lanreotide before surgery to surgery alone in preventing pancreatic fistulas in patients with pancreatic cancer or a pancreatic lesion that could become cancerous.
- Trial name
- NCT06807437
- Testing
- Biospecimen Collection, Distal Pancreatectomy, Lanreotide
- Where
- 118 sites in United States
- Volunteers
- 274 people
- Sponsor
- SWOG Cancer Research Network
Pancreatic Fistula
Indocyanine Green Fluorescence in Evaluation of Pancreatic Remnant Perfusion.
Main goal of this study is to evaluate the blood flow in a post resection pancreatic remnant after pancreaticoduodenectomy with use of indocyanine green fluorescence.
- Trial name
- NCT06198400
- Testing
- Perioperative assessment of the perfusion of post-resection pancreatic remnant using indocyanine green-VerDye
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Surgery Site Fistula
Hypopharynx ICG to Reduce the Fistula Rate in Patients Undergoing Salvage Laryngectomy
A laryngectomy involves removing the voice box from the throat. After the voice box has been removed from the throat, the surgeon sews the throat closed.
- Trial name
- NCT05350540
- Testing
- ICG dye
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Pancreatic Fistula, Pancreas Cancer
Preoperative Inflammatory Biomarkers and Postoperative Day 1 Drain Amylase Value Predict Pancreatic Fistula After Pancreaticoduodenectomy
Particularly, pancreatic fistula is the most common and serious complication after pancreaticoduodenectomy (PD) and is reported in up to 40% of cases.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Inflammatory Response
- Trial name
- NCT04361682
- Testing
- Surgical Drain Management
- Volunteers
- 227 people
- Sponsor
- Campus Bio-Medico University