Clinical trials: Surgery With General Anesthesia
Intraoperative Complications, Postoperative Complications
Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade.
The goal of this study is to investigate the effect of depth of neuromuscular block (NMB) on global and regional (dependent versus nondependent) respiratory mechanics during laparoscopic surgery.
- Conditions
- Intraoperative Complications, Postoperative Complications, Laparoscopy, Surgical Complications From General Anesthesia
- Trial name
- NCT02025075
- Testing
- Rocuronium
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Frailty, Neuromuscular Blockade
Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital…
- Conditions
- Frailty, Neuromuscular Blockade, General Anesthetic Drug Adverse Reaction, Gynecologic Cancer
- Trial name
- FIGO (NCT06216002)
- Testing
- Train of four nerve stimulator
- Where
- Thailand
- Volunteers
- 356 people
- Sponsor
- Mahidol University
Anesthesia Recovery Period
Street Fitness in Surgical Patients Undergoing General Anesthesia After Reversal of Neuromuscular Blockade
Rationale: Recovery from outpatient anesthesia includes dissipation of anesthetics agents, normalization of physiological function, observation for medical or surgical complications, treatment of immediate side effects of…
- Trial name
- SFINX (NCT01453530)
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Patients Requiring Ambulatory Surgery Under General Anesthesia
Propofol for Supreme LMA Insertion With and Without Remifentanil
The aims of this study were to determine the clinically required concentration of propofol for LMA Supreme insertion, and to examine to what extent remifentanil reduces the dose of propofol and improves conditions for it's…
- Trial name
- SC50 (NCT01974648)
- Testing
- propofol, propofol and remifentanil
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Anesthesia, Fluid Responsiveness
Assessment Of Carotid Flow During General Anesthesia
Proper identification of patients who would benefit from fluid infusion (fluid responsiveness) is one of the most crucial challenges in anaesthesia and critical care.
- Trial name
- NCT03713008
- Testing
- Fluid bolus
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Laryngoscopic Stress Response, Video Laryngoscopy
Effect of Video Laryngoscopy Versus Conventional Laryngoscopy Upon Hemodynamics
In general anestheisa airway is secured by passing a tube down the widpipe. This helps the patient to breath via ventilator during anesthesia.
- Conditions
- Laryngoscopic Stress Response, Video Laryngoscopy, Conventional Laryngoscopy
- Trial name
- NCT07300878
- Testing
- C MAC hyperangulated video laryngoscopy, Conventional macintosh laryngoscopy
- Where
- Pakistan
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Double Level Lumbar Spondylolisthesis (L3-L5), Posterior Lumbar Interbody Fusion (PLIF)
Effect of Addition of Dexmedetomidine During Ultrasound Guided Bilateral Single Shot Erector Spinae Plane Block in Patients Undergoing Posterior Lumbar Interbody Fusion Under General Anesthesia
Posterior lumbar interbody fusion (PLIF) is the management of choice in double level lumbar (L) spondylolisthesis (L3-L5) after ineffective conservative treatment.
- Conditions
- Double Level Lumbar Spondylolisthesis (L3-L5), Posterior Lumbar Interbody Fusion (PLIF), Lumbar Fixation Surgery
- Trial name
- NCT03746418
- Testing
- Ultrasound Guided Bilateral single shot Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Breast Cancer
Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery
The purpose of this project is to determine if there is a difference between paravertebral block and general anesthesia in terms of time to discharge from the Post-Anesthesia Care Unit and pain level in patients undergoing…
- Trial name
- NCT00645138
- Testing
- Paravertebral Block, General Anesthesia
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Opioid-free Anesthesia, Cardiac Surgery
Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial
Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol).
- Trial name
- OFACAR (NCT04886453)
- Testing
- Balanced general anesthesia without morphine, Standard general anesthesia balanced with morphine, Data collection
- Where
- France
- Volunteers
- 321 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Opioids, Clinical Trial
The Comparative Efficacy and Safety of Two General Anesthesia Protocols Consisting of Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane for Gynaecology Surgery in Cameroon
Recently, a lot of side effects have been identified from the perioperative use of opioids. To remedy this, anesthesia research has recently focused on providing safe general anesthesia without opioids in a new concept or…
- Conditions
- Opioids, Clinical Trial, Anesthesia, Gynecology
- Trial name
- OFA-AFRO (NCT04737473)
- Testing
- Opiod Free Anesthesia
- Where
- Cameroon
- Volunteers
- 36 people
- Sponsor
- University of Yaounde 1
Hip Fractures
Combined Plexus Block for Hip Fracture Surgery.
Hip fracture surgery requires high risk anesthetic procedure for elderly patients (1). General anesthesia, continuous spinal anesthesia and peripheral nerve blocks are three anesthetic techniques possible.
- Trial name
- NCT03356704
- Testing
- no intervention
- Volunteers
- 593 people
- Sponsor
- University Hospital, Montpellier
Cesarean Section
Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine
Cesarean delivery under general anesthesia is one of few only surgical procedures, where the most important factor of safety is the speed of the surgery, as a newborn adaptation strongly depends on a time between induction to the…
- Trial name
- NCT01941628
- Testing
- Rocuronium, Succinylcholine
- Where
- Czechia
- Volunteers
- 91 people
- Sponsor
- Charles University, Czech Republic
Mechanical Ventilation, Surgeries Undergoing General Anesthesia
Preoperative Characteristics and Outcomes of Neonates Undergoing Surgical Procedures in the NICU
This retrospective observational study evaluates neonates who underwent surgical procedures during admission to a neonatal intensive care unit (NICU).
- Trial name
- NeoSurg-Resp (NCT07793812)
- Testing
- Surgical Procedures
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Ayberk Ozkavakli
Recovery Following Cholecystectomy
Multi-dose Acetaminophen for Patients Undergoing General Anesthesia
Study Objective The aim of the proposed study is to examine the effect of Q4 hour multidose IV acetaminophen on patients' readiness for discharge.
- Trial name
- NCT02832687
- Testing
- Acetaminophen, normal saline
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Rutgers, The State University of New Jersey
Delirium
Clinical Investigation of an Eye-Tracking Device as a Predictor of Delirium in the Recovery Room After Surgery With General Anesthesia
Neurotrack™ is an FDA-approved device for measuring and tracking cognitive decline, as may occur with age-related cognitive decline and Alzheimer's disease.
- Trial name
- NCT05579093
- Testing
- Cognitive test + Pupillary measure
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cesarean Section Surgery, TAP Blocks
Post-Cesarean Gastrointestinal Dysfunction
General anesthesia has a range of effects that can lead to gastrointestinal (GI) system dysfunctions in the postoperative period.
- Conditions
- Cesarean Section Surgery, TAP Blocks, Gastrointestinal Dysfunction
- Trial name
- NCT07067021
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Orotracheal Intubation in Infants Requiring General Anaesthesia for Surgery
Comparing the Efficacy of King Vision in Infants
The primary objective of this study is to find out whether the intubation success rates of Kingvision video laryngoscope is better than that of the conventional laryngoscopes in children < 1 year of age?
- Trial name
- NCT03378154
- Testing
- Orotracheal intubation in infants with Macintosh, Orotracheal intubation in infants with King vision
- Where
- India
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research