Clinical trials: Surgery for Colorectal Cancer.
Treatment Side Effects, Colorectal Cancer
Surgery Versus Endoscopic Resection for Incompletely Removed Early Colon CAnceR
Randomized head-to-head comparison trial among patients who have undergone incomplete endoscopic resection of early colon cancer to evaluate the benefits, harms and burdens, as well as the ecological footprint and…
- Trial name
- SCAR (NCT06057350)
- Testing
- Tumor removal
- Where
- 3 sites in Norway, Poland
- Volunteers
- 304 people
- Sponsor
- Norwegian Department of Health and Social Affairs
Rectal Cancer
COLOR II: Laparoscopic Versus Open Rectal Cancer Removal
COLOR II is a randomized, international, multi center study comparing the outcomes of laparoscopic and conventional resection of rectal carcinoma below 15 cm with curative intent.
- Trial name
- COLORII (NCT00297791)
- Testing
- surgery
- Where
- 35 sites in Belgium, Canada and 7 more
- Volunteers
- 1,044 people
- Sponsor
- Nova Scotia Health Authority
Lower Urinary Tract Symptoms, Colorectal Disorders
Lower Urinary Tract and Sexual Function in Women Following Surgery for Colorectal Disorders
This is a prevalence study evaluating lower urinary tract, prolapse, bowel, and sexual symptoms in women with a colorectal disorder who are planning to undergo surgery.
- Trial name
- NCT00667550
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, Irvine
Gastric Cancer, Colon Cancer
Postoperative Oral Nutritional Supplementation After Major Gastrointestinal Surgery
Patients who underwent major gastrointestinal surgery is potentially at risk of malnutrition due to reduced oral intake, increased nutritional need, reduced gastrointestinal absorption function, and/or metabolic changes after…
- Conditions
- Gastric Cancer, Colon Cancer, Pancreatic Cancer, Duodenal Cancer
- Trial name
- NCT01838109
- Testing
- oral nutritional supplement
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Seoul National University Hospital
Rectal Adenocarcinoma, Non Metastatic
A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity
A phase II, single-center, non-profit, interventional study on patients affected by rectal adenocarcinoma. Patients will be stratified into three groups based on pre-treatment clinical stage.
- Trial name
- INTERPRETE (NCT06952101)
- Testing
- Sparing Approach, experimental chemoradiotherapy, Standard Chemotherapy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Colon Cancer, Robotic Surgery
Effectiveness of Robotic Surgery for Right Colon Cancer
This study aims to explore through a multi-center, randomized controlled clinical study whether robot-assisted radical resection of right colon cancer is superior to laparoscopic surgery in terms of surgical quality and…
- Trial name
- NCT06421974
- Testing
- DaVinci si or xi system, laparoscopic radical resection
- Where
- China
- Volunteers
- 610 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Carcinoma
Robot-assisted Versus Laparoscopic Surgery for Mid/Low Rectal Cancer
The purpose of this study is to evaluate the safety and oncological feasibility of robot-assisted surgery for mid/low rectal carcinoma compared with laparoscopic surgery.
- Trial name
- REAL (NCT02817126)
- Testing
- Robot-assisted resection, Laparoscopic resection
- Where
- 11 sites in China
- Volunteers
- 1,240 people
- Sponsor
- Fudan University
Stage II Colon Cancer, Stage III Colon Cancer
Real-world Retrospective Data Analysis of Adjuvant Therapy for Patients With Stage II-III Colon Cancer After Radical Surgery
Background: 1. . The incidence and mortality of colon cancer are high in China and in the world. 2. . The treatment of many patients in the real world is not standardized, and there are problems such as over-treatment or…
- Conditions
- Stage II Colon Cancer, Stage III Colon Cancer, Adjuvant Therapy
- Trial name
- NCT03958435
- Where
- 3 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Surgery for Stage II / III Primary Colorectal Cancer
Mu Opioid Receptor 1 Expression and Activation Patterns in Colorectal Cancer
Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery.
- Trial name
- NCT04353882
- Testing
- Assess the difference in MOR-1 expression between healthy and tumor tissue
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario La Fe
Visceral Obesity, Rectal Cancer
Comparison of Robotic Versus Laparoscopic Surgery for Visceral Obesity in Mid-Low Rectal Cancer: A Propensity-Matched Analysis
Our team has previously published articles providing detailed descriptions of the steps involved in both RS and LS. All surgeries adhered to the total mesorectal excision (TME) principle.
- Conditions
- Visceral Obesity, Rectal Cancer, Robotic Surgery
- Trial name
- NCT06397053
- Testing
- robotic surgery
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Daorong Wang
Stage II Colon Cancer, Stage III Colon Cancer
Exercise and Colon Cancer
Despite the success of surgery and chemotherapy among people with colon cancer, 30-50% of patients develop recurrent disease. Physical activity has emerged as a potential lifestyle intervention to reduce cancer recurrence and…
- Trial name
- NCT02250053
- Testing
- Exercise
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer
Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00114231
- Testing
- capecitabine, oxaliplatin, neoadjuvant therapy
- Where
- 67 sites in United States
- Volunteers
- 90 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Cancer
Surgery Alone Versus Neoadjuvant Treatment Followed by Surgery For MRI-defined T3 Mid-low Rectal Cancer
Neoadjuvant treatments (nCRT) are becoming the standard treatment for patients with stage II or stage III mid-low rectal cancer.
- Trial name
- NCT05496270
- Testing
- total mesorectal excision
- Volunteers
- 1,509 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer
5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer
The purpose of this Phase II study will be to investigate the antiangiogenic agent, aflibercept, in combination with chemoradiation as preoperative treatment for patients with stage II/III rectal cancer, followed by 4 months of…
- Trial name
- NCT01749956
- Testing
- Radiation, Aflibercept, Surgery
- Where
- 11 sites in United States
- Volunteers
- 39 people
- Sponsor
- SCRI Development Innovations, LLC
Colon Neoplasm
A Novel Adaptive Anastomotic Technique for Left-sided Colonic Resection
The goal of this pilot clinical trial is provide preminary evidence of the effectiveness of the C-REX device, developed by CarpoNovum AB, in preventing anastomotic leak and improving anastomosis healing after sigmoid or high…
- Trial name
- NOVA (NCT06615583)
- Testing
- Surgical device
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Colorectal Neoplasms
Preop CPET Testing and Exercise Training in Colorectal Patients
Colorectal Surgery Preoperative Exercise Training is a study being run by the colorectal surgery team at the Norfolk and Norwich University Hospital and the University of East Anglia to look at the role of exercise before surgery…
- Trial name
- NCT01924897
- Testing
- Exercise training
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of East Anglia
Rectal Neoplasms, Neoplastic Cells, Circulating
Change of Circulating Tumor Cells During Laparoscopic or Transanal Endoscopic Surgery for Rectal Cancer.
The primary purpose of this study is to compare the changes of circulating tumor cells (CTCs) at different time points in rectal cancer patients undergoing laparoscopic or transanal endoscopic radical resection.
- Conditions
- Rectal Neoplasms, Neoplastic Cells, Circulating, Laparoscopic Surgery, Transanal Endoscopic Surgery
- Trial name
- NCT05109130
- Testing
- Surgical approach
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer, Colorectal Cancer
Endoscopic Visualisation of Anastomosis in Colorectal Cancer Surgery
A randomised feasibility study into the use of endoscopic visualisation of rectal anastomosis vs. current practice and the effect on anastomotic leak rates in patients undergoing rectal surgery for bowel cancer in a tertiary…
- Conditions
- Rectal Cancer, Colorectal Cancer, Anastomotic Leak, Intraoperative Endoscopy
- Trial name
- EVACCS (NCT04738240)
- Testing
- Intra-operative endoscopy
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Plymouth
Rectal Cancer Surgery, Randomized Clinical Trial
Drainage After Rectal Excision for Rectal Cancer
After rectal excision, the rate of anastomotic leak and abscess is higher than after colic surgery. In order to limit and avoid the risk of pelvic sepsis after rectal excision, a prophylactic pelvic drainage is usually used.
- Conditions
- Rectal Cancer Surgery, Randomized Clinical Trial, Multicenter Study, Pelvic Drainage
- Trial name
- GRECCAR 5 (NCT01269567)
- Testing
- Laying and management of the drain (strictly randomized arm with drainage), No pelvic drainage
- Where
- 22 sites in France
- Volunteers
- 494 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Carcinoma
Laparoscopic Assisted Versus Open Resection for Colorectal Carcinoma
The aim of the investigators' randomized trial is to compare the short-term clinical outcome and survival between laparoscopic-assisted and open resection of colorectal carcinoma.
- Trial name
- NCT00485316
- Testing
- Laparoscopic assisted resection of colorectal carcinoma
- Where
- China
- Sponsor
- Chinese University of Hong Kong