Clinical trials: Surgery of Breast Cancer
Depression, Anxiety
Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression
This project employs a prospective, randomized, controlled, blinded, dual-center study design to investigate the effects of intraoperative esketamine on perioperative anxiety and depression symptoms in patients with severe…
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07374211
- Testing
- Esketamine 0.3mg/kg, normal saline
- Volunteers
- 242 people
- Sponsor
- Chinese PLA General Hospital
Breast Cancer Invasive, Chemotherapy
Receptive Music Therapy Effects on Anxiety, Depression, QoL, and EGF, IL-8, and NfL During the Breast Cancer Treatment.
The goal of this clinical study is to investigate whether receptive music therapy can help women with breast cancer by reducing anxiety and depression symptoms, improving quality of life, and influencing specific analytes in…
- Conditions
- Breast Cancer Invasive, Chemotherapy, Breast Cancer Surgery, Breast Cancer
- Trial name
- NCT07483034
- Testing
- Music intervention
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Brigita Vilc
Ductal Breast Carcinoma In Situ, Estrogen Receptor Positive
Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast
This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer cells.
- Trial name
- NCT02993159
- Testing
- Afimoxifene, Laboratory Biomarker Analysis, Tamoxifen Citrate
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Northwestern University
Breast Cancer
The Telemark Score: a Reliable Method for Evaluation of Results After Breast Surgery
This paper will present a specific tool for evaluation of cosmetic results after breast conserving surgery (BCS) and secondary breast reconstruction with free DIEP-flap.
- Trial name
- TBS (NCT02853227)
- Testing
- digital photography
- Volunteers
- 376 people
- Sponsor
- Sykehuset Telemark
Breast Cancer
A Nationwide Multicenter, Single-arm, Retrospective Study of Delayed Endoscopic DTI-BR After Simple Mastectomy
This study is a nationwide multicenter, single-arm, retrospective study. The study aims to conduct a detailed analysis of operation-related parameters, aesthetic outcomes (e.g., BREAST-Q scores and Harris scores), and safety…
- Trial name
- DEDTI-BR (NCT07257003)
- Testing
- delayed endoscopic direct-to-implant breast reconstruction via axillary approach after simple mastectomy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Du Zhenggui
Breast Cancer, Postoperative Pain
Preoperative Sleep Quality and Postoperative Outcomes in Breast Surgery
Brief Summary: This prospective, single-center observational study examined the association between preoperative sleep quality and postoperative outcomes in women undergoing elective breast cancer surgery.
- Conditions
- Breast Cancer, Postoperative Pain, Inflammation
- Trial name
- NCT07547774
- Testing
- Preoperative Sleep Quality Assessment (PSQI)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Breast Cancer, Breast Reconstruction
Comparison of Safety and Patients-Reported Outcomes Between Single-Port Endoscopic and Conventional Nipple-Sparing Mastectomy With Immediate Implant Reconstruction
Why is this study being done? Breast cancer is very common among women. Today, patients not only seek effective treatment but also care about their quality of life after surgery, including how they feel and how satisfied they are…
- Trial name
- NCT07410728
- Where
- China
- Volunteers
- 471 people
- Sponsor
- Xijing Hospital
Breast Cancer
The Effect of Meditation and Massage Therapy for Breast Cancer Patients Undergoing Tissue Reconstruction
In this study we propose to explore the efficacy of massage therapy combined with meditation in women recovering from tissue reconstruction after mastectomy for breast cancer. Patients will be randomized into 2 groups.
- Trial name
- NCT01736605
- Testing
- Massage, Massage combined with meditation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Breast Cancer
Study of Anastrozole, Letrozole, or Exemestane With or Without Tamoxifen in Treating Postmenopausal Women With Hormone-Responsive Breast Cancer That Has Been Completely Removed By Surgery
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking use of estrogen by the tumor cells.
- Trial name
- NCT00541086
- Testing
- anastrozole, exemestane, letrozole
- Where
- 5 sites in Italy
- Volunteers
- 3,697 people
- Sponsor
- Gruppo Italiano Mammella (GIM)
Breast Fibrosis, Breast Cancer
An Integrated Optimization of Surgery and Radiotherapy Techniques to Improve Cosmetic Outcome and Quality of Life in Breast Conserving Therapy for Breast Cancer Patients (STARLINGS Study)
To assess the role of different combinations of (oncoplastic) surgery and radiotherapy techniques as risk factors for moderate to severe fibrosis and for moderate to poor cosmetic outcome.
- Conditions
- Breast Fibrosis, Breast Cancer, Breast Cancer Female, Breast Neoplasms
- Trial name
- STARLINGS (NCT05263362)
- Testing
- no intervention
- Where
- 4 sites in Netherlands
- Volunteers
- 775 people
- Sponsor
- Erasmus Medical Center
Breast Cancer, Surgery
The E-consult Application for Patients With Breast Cancer: Interest in Empathy and Empowerment of Patients.
Demonstrate that the use of this application in consultation could improve the empathy perceived of the doctors by the patients after the consultation.
- Trial name
- e-CONSULT (NCT04688762)
- Testing
- e-consult application (tool)
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Centre Francois Baclesse
Infiltrating Ductal Carcinoma
Contribution of 18FDG PET-Scan in Tumour Volume Determination in Patients Operated of Breast Cancer
Use of positron emission tomography (PET) in determination of functional tumour volume can provide usable information for radiotherapy to define the irradiated volume.
- Trial name
- VOSETEP (NCT01621529)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial
This phase II trial tests how well an imaging procedure called fludeoxyglucose F-18 (FDG) positron emission tomography/computed tomography (PET/CT) works in predicting response to standard of care chemotherapy prior to surgery in…
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Positive Breast Carcinoma, Invasive Breast Carcinoma
- Trial name
- NCT05710328
- Testing
- Chemotherapy, Computed Tomography, Fludeoxyglucose F-18
- Where
- 102 sites in United States, Puerto Rico
- Volunteers
- 235 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Breast Cancer
Intraoperative Use of ClearEdge Device in Breast Conserving Surgery
Multi center, pivotal prospective, randomized clinical trial The proposed randomized controlled study will evaluate the benefits of adding the ClearEdge imaging device to the Standard of Care (SoC) of margins assessment in breast…
- Trial name
- NCT05456373
- Testing
- ClearEdge device
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- LS BioPath
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery
This phase II trial evaluates manual lymphatic drainage breast massage for reducing treatment-related side effects in women undergoing radiation therapy after breast conserving surgery for breast cancer that has not spread to…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Localized Breast Carcinoma
- Trial name
- NCT06297265
- Testing
- Lymphedema Management, Questionnaire Administration, Adjuvant breast radiation therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Breast Cancer
Comparing Local Anesthesia With General Anesthesia for Breast Cancer Surgery
The purpose of this study is to determine therapeutic benefits by local anesthetic technique for breast cancer.
- Trial name
- NCT00938171
- Testing
- Local anesthesia, General anesthesia
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Mackay Memorial Hospital
Breast Cancer
The Effect of Digital Technology-Supported Education on Patients Undergoing Breast Reconstruction After Mastectomy: A Randomized Controlled Study
The goal of this randomized, controlled study is to test the effectiveness of digital technology-supported education on patients undergoing breast reconstruction after mastectomy.
- Trial name
- NCT06166953
- Testing
- digital technology-supported education
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Baskent University
Breast Neoplasms
Robotic-Assisted vs. Endoscopic-Assisted Sentinel Lymph Node Biopsy in Breast Cancer
This is a retrospective observational study comparing the accuracy and safety of robotic-assisted versus endoscopic-assisted sentinel lymph node biopsy (SLNB) in patients with breast cancer.
- Trial name
- NCT07741734
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Breast Cancer
SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery
This is a multicenter, first-in-human (FIH), open label, Phase 1 dose escalation and recommended Phase 2 dose (RP2D) extension trial with a primary objective to define the RP2D of SRG-514 when administered intraoperatively to…
- Trial name
- NCT06300411
- Testing
- SRG-514
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- SURGE Therapeutics
Breast Diseases
A Randomized Controlled Comparative Study of Ultrasound-guided Paravertebral Blocks as Part of a Multimodal Regimen for Ambulatory Breast Cancer Surgery
General anesthesia and morphine based pain medicine analgesia has been the mainstay of practice in breast cancer surgery at Women's College Hospital.
- Trial name
- NCT01654432
- Testing
- Paravertebral Blocks (PVB)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Women's College Hospital
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