Clinical trials: Surgery of Breast Cancer
Breast Cancer
3-Dimensional Conformal Radiation Therapy or Internal Radiation Therapy After Breast-Conserving Surgery in Treating Women With Stage I or Stage II Breast Cancer
RATIONALE: Specialized radiation therapy, such as 3-dimensional conformal radiation therapy, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00802711
- Testing
- 3-dimensional conformal radiation therapy, brachytherapy
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- Cancer Trials Ireland
Breast Cancer Patients
Rhomboid Intercostal Block With Sub-Serratus Plane Block Versus Erector Spinae Block
This study compares two nerve block techniques-Rhomboid Intercostal with Sub-Serratus Plane Block versus Erector Spinae Plane Block-for pain relief after breast cancer surgery.
- Trial name
- RISS-ESPB (NCT07041762)
- Testing
- Rhomboid Intercostal Block with Sub-Serratus Plane Block, Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Breast Cancer Surgery
Effect of Intravenous S-ketamine on Opioid Consumption
Female patients with an American Society of Anesthesia (ASA) physical status I-II, scheduled for elective breast cancer surgery will be included in the study.
- Trial name
- NCT05060068
- Testing
- S-ketamine (low dose), S-ketamine (high dose)
- Where
- China
- Volunteers
- 345 people
- Sponsor
- The Second Hospital of Anhui Medical University
Breast Neoplasms
Safety and Effectiveness of Robotic-Assisted Remote Surgery for Breast Tumors
This is a multicenter retrospective clinical study. The research aims to explore the safety and efficacy of robotic single-port thoracoscopic minimally invasive surgery for breast cancer patients.
- Trial name
- NCT07850323
- Testing
- Robotic-assisted axillary lymph node dissection
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Breast Cancer
A Study to Evaluate the Accuracy of a Breast Cancer Locator (BCL) in Patients With Palpable Cancers
In this study, the investigators will enroll women with palpable cancers to assess the accuracy of the Breast Cancer Locator (BCL) and the concomitant procedure as a vehicle to optimize and validate the approach in such surgical…
- Trial name
- NCT02550210
- Testing
- Breast Cancer Locator (BCL)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Anesthetics, Remifentanil
Use of a Remifentanil-propofol Mixture in Patients Undergoing Breast Cancer Surgery
Co-administration of propofol and remifentanil is considered to be an ideal total intravenous anesthesia technique, which is widely used in induction and maintenance of general anesthesia.
- Conditions
- Anesthetics, Remifentanil, Propofol
- Trial name
- NCT03817359
- Testing
- Remifentanil-propofol mixture
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Breast Cancer
Evaluation of the Feasibility of a Study Comparing Local Anesthesia and General Anesthesia in Conservative Surgery for Breast Cancer
The conservative surgery for breast cancer is the first treatment for cancer and includes : A partial mastectomy (removal of part of the breast) A sentinel lymph node analysis, depending on the case (analysis of the first lymph…
- Trial name
- ESCAL (NCT06910280)
- Testing
- conservative surgery for breast cancer with local anesthesia, conservative surgery for breast cancer with general anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Tumors, Breast
Prospective Analysis of EnVisio Spatial Intelligence for Soft Tissue Localization and Guided Surgical Excision
Observational study. The purpose of this study is to evaluate the use of real-time surgical navigation for the localization and surgical removal of soft tissue tumors.
- Trial name
- NCT06572410
- Testing
- EnVisio Navigation System
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Elucent Medical
Non Metastatic Breast Cancer
The Impact of Oncoplastic Breast Surgery on the Oncological Safety and Patient Satisfaction
The aim of this study is to asses the oncological safety of oncoplastic breast surgery, its impact on patient satisfaction and is it worthy for general breast surgeon to learn different oncoplastic techniques.
- Trial name
- NCT02901223
- Testing
- Standard quadrantectomy, oncoplastic breast surgery
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Breast Neoplasm
SAVI SCOUT Clinical Evaluation Study
The purpose of this study is to evaluate the performance of the SAVI SCOUT® Surgical Guidance System (SAVI SCOUT). The SAVI SCOUT is a medical device, used to provide real-time guidance during localized excisional biopsy or…
- Trial name
- NCT02370082
- Testing
- Localization of breast lesion
- Volunteers
- 150 people
- Sponsor
- Cianna Medical, Inc.
Breast Cancer, Neoadjuvant Therapy
Feasibility Study of Intraoperative Detection of Residual Cancer in Breast Cancer Patients
This is a prospective, multi-center, randomized, clinical trial evaluating patients undergoing breast conserving surgery using the LUM Imaging System.
- Trial name
- NCT04440982
- Testing
- LUM015, Lum Imaging System
- Where
- 6 sites in United States
- Volunteers
- 98 people
- Sponsor
- Lumicell, Inc.
Brain Metastases, Adult
Neoadjuvant Immunotherapy in Brain Metastases
The purpose of this phase 2 study is to assess the feasibility and efficacy of neoadjuvant immunotherapy in patients with previously untreated, surgically-resectable, solid tumor brain metastases.
- Trial name
- NCT04434560
- Testing
- Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Sarah Sammons, MD
Breast Cancer-Related Arm Lymphedema, Quality of Life Impairment
Prehabilitation of Breast Cancer-Related Lymphedema
This prospective prehabilitation study aims to evaluate the effects of an individualized exercise program initiated before breast cancer surgery and continued for 12 months postoperatively.
- Conditions
- Breast Cancer-Related Arm Lymphedema, Quality of Life Impairment, Fatigue Syndrome, Chronic, Prehabilitation
- Trial name
- NCT07301580
- Testing
- Prehabilitation Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Breast Cancer, Prostate Cancer
Magnetic Resonance Imaging of Lymph Nodes Using Ferumoxytol in Patients With Primary Prostate or Breast Cancer
RATIONALE: Diagnostic procedures such as magnetic resonance imaging (MRI) using ferumoxytol may improve the ability to detect cancer that has spread to the lymph nodes and may help plan effective cancer treatment.
- Trial name
- NCT00087347
- Testing
- ferumoxytol, magnetic resonance imaging
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Outcome of Neo-adjuvant Chemotherapy Followed by Breast Conservative Surgery in Breast Cancer in Upper Egypt
Systemic chemotherapy along with radiotherapy has been successfully used to post-operatively manage patients following tumour resection in breast cancer.
- Trial name
- NCT03696004
- Testing
- FEC-100
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Breast Cancer, Radiation Toxicity
Hypofractionated Versus Conventional Fractionation Radiotherapy
This study was designed to evaluate the acute toxicity and quality of life of hypofractionated radiation versus conventional when regional node irradiation is indicated after breast-conserving surgery or mastectomy.
- Trial name
- NCT04015531
- Testing
- Conventional radiotherapy, Hypofractionated radiotherapy
- Volunteers
- 80 people
- Sponsor
- Hospital da Baleia
Lymphedema, Breast Cancer
The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema
The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) 15 months after randomization…
- Trial name
- LYMPH (NCT05890677)
- Testing
- Surgical Intervention, Conservative Complex Physical Decongestion Therapy
- Where
- 36 sites in United States, Austria and 13 more
- Volunteers
- 280 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer
Lymph Node Radiation Therapy in Patients With Stage I, Stage II, or Stage III Breast Cancer That Has Been Surgically Removed
RATIONALE: Radiation therapy may kill any tumor cells remaining after surgery. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared to no further therapy in treating women with…
- Trial name
- NCT00002851
- Testing
- adjuvant therapy, low-LET electron therapy, low-LET photon therapy
- Where
- 48 sites in Belgium, Bosnia and Herzegovina and 12 more
- Volunteers
- 4,000 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer, Exercise
Virtual Reality-based Exercise Training in Radiotherapy Period After Breast Cancer Surgery
The main purpose of this study is to compare two different exercise approaches during the radiotherapy period in patients who have undergone breast cancer surgery.
- Conditions
- Breast Cancer, Exercise, Upper Extremity Dysfunction
- Trial name
- NCT04618120
- Testing
- Virtual reality-based exercise, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Gazi University
Breast Neoplasms
Study to Compare Neoadjuvant Combination of Trastuzumab and Pertuzumab With Concurrent Taxane Chemotherapy or Endocrine Therapy and Quality of Life Assessment Under Adjuvant Therapy in Operable HER2+/HR+ Breast Cancer Patients
This is a prospective, phase IIa, multicenter, randomized, open-label study comparing a pre-surgical combination of trastuzumab and pertuzumab with concurrent weekly paclitaxel chemotherapy or endocrine therapy given for 12 weeks…
- Trial name
- TP-II (NCT03272477)
- Testing
- Perjeta Injectable Product, Herceptin, Tamoxifen
- Where
- Germany
- Volunteers
- 257 people
- Sponsor
- Palleos Healthcare GmbH
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