Clinical trials: Surgery of Breast Cancer
Breast Cancer Female
Xenografts Development From Surgical Tumor Samples of Patients With Triple Negative or Luminal B Breast Cancer
Patient derived xenografts (PDX) from mammary tumors are usually made from metastatic tumors. Indeed, PDX from primitive mammary tumors or after neoadjuvant treatment are still rare.
- Trial name
- XenoBreast (NCT04133077)
- Testing
- blood samples collection
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Centre Jean Perrin
Radiodermatitis
Exploratory Study of Norepinephrine to Prevent Radiodermatitis in Breast Cancer Patients
This study, a nonrandomized open-label Phase I safety and exploratory study, will evaluate the safety of topical norepinephrine in post-surgical breast cancer patients who are undergoing radiation therapy.
- Trial name
- NCT01263366
- Testing
- Norepinephrine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- ProCertus BioPharm, Inc
Stage 0/1 Breast Cancer, Post Biopsy
Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer
NAC is the N-acetyl derivative of the naturally occurring amino acid, L-cysteine. It is a common over-the-counter supplement and also is available as an injectable pharmaceutical that protects the liver in cases of acetaminophen…
- Conditions
- Stage 0/1 Breast Cancer, Post Biopsy, Pre-surgery
- Trial name
- NAC (NCT01878695)
- Testing
- IV/oral n-acetylcysteine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Breast Cancer, Early-Stage Invasive Breast Carcinoma
Radiotherapy and Long-term Outcomes in Early Breast Cancer With SLNB Omission
This prospective, multicenter observational cohort study evaluates long-term outcomes in patients with early-stage invasive breast cancer who undergo breast-conserving surgery without sentinel lymph node biopsy or other axillary…
- Trial name
- APROOB Cohort (NCT07803081)
- Testing
- Adjuvant Breast Radiotherapy
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Breast Cancer
A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
The main purpose of this study is to learn if adding bevacizumab to standard treatment with chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) for early stage HER2-negative breast cancer will prevent breast cancer from…
- Trial name
- NCT00887536
- Testing
- bevacizumab, docetaxel, doxorubicin
- Where
- 533 sites in United States, Ireland
- Volunteers
- 1,613 people
- Sponsor
- NSABP Foundation Inc
Breast Neoplasms, Colonic Neoplasms
Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia
The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.
- Conditions
- Breast Neoplasms, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- CAN (NCT01975064)
- Testing
- Propofol, Sevoflurane
- Where
- 15 sites in China, Poland and 1 more
- Volunteers
- 5,774 people
- Sponsor
- Uppsala University
Breast Cancer, Radical Mastectomy Surgery
Efficacy of Tramadol With Levobupivacaine for Modified Pectoral Nerve Block
The aim of this study is to evaluate the addition of tramadol combined with levobupivacaine in the reduction of postoperative pain, postoperative opioid consumption after modified radical mastectomy surgery.
- Trial name
- NCT02625506
- Testing
- Levobupivacaine, Levobupivacaine and Tramadol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm
Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of veliparib when given together with irinotecan hydrochloride in treating patients with cancer that has spread to other parts of the body or that cannot be removed by…
- Conditions
- Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Triple-Negative Breast Carcinoma, Unresectable Solid Neoplasm
- Trial name
- NCT00576654
- Testing
- Irinotecan Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 5 sites in United States
- Volunteers
- 73 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Erlotinib in Treating Women Undergoing Surgery For Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This clinical trial is studying how well erlotinib works in treating women undergoing surgery for stage I…
- Trial name
- NCT00503841
- Testing
- erlotinib hydrochloride, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Breast Cancer and Rehabilitation
Effect of Preoperative Rehabilitation Exercise on Improving Postoperative Lymphedema, Quality of Life and Care Needs in Patients With Breast Cancer Surgery
Breast cancer is one of the most common cancers among women worldwide, with surgery being a primary treatment. However, surgical tumor resection combined with lymph node dissection often leads to upper extremity lymphedema as a…
- Trial name
- NCT07743294
- Testing
- Preoperative Upper Limb Rehabilitation Exercise, Standard Nursing Care and Education
- Where
- 2 sites in Taiwan
- Volunteers
- 105 people
- Sponsor
- National Taiwan University Hospital
Ablation, Breast Cancer
A Cohort Study of Combined Cryoablation and Thermal Ablation for Non-surgical Treatment of Breast Cancer Patients
Although surgical resection is the gold standard for early breast cancer treatment, some patients cannot tolerate surgery due to medical conditions or refuse surgical treatment for cosmetic reasons.
- Trial name
- NCT07238894
- Testing
- Combined Cryoablation and Thermal Ablation system
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Breast Neoplasms
Argon Plasma Coagulation Scalpel on Surgical Treatment of Breast Cancer
The investigators are selecting sixty (60) with breast cancer diagnoses where the surgical treatment is indicated.Furthermore the investigators divided in two groups : 1) surgical treatment using regular electric scalpel ; 2)…
- Trial name
- NCT02548338
- Testing
- argon plasma coagulation
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Breast Cancer
Prediction of Long-term Arm Morbidity Following Breast Cancer Surgeries and Treatments
Background: Breast cancer (BC) treatments usually include a combination of surgery, chemotherapy and radiation. These life-saving treatments cause high percentages of arm morbidity, which often lasts for months, or develops…
- Trial name
- NCT05950685
- Where
- Israel
- Volunteers
- 1,602 people
- Sponsor
- Ifat Klein
Bone Cancer, Bone Metastases
Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System
The goal of this prospective, non-randomized, single-arm, phase 2 study is to evaluate the safety and effectiveness of this treatment using this ExAblate conformal system in the treatment of pain resulting from metastatic bone…
- Conditions
- Bone Cancer, Bone Metastases, Pain
- Trial name
- NCT01085565
- Testing
- ExAblate 2100
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- InSightec
Breast Cancer
Analgesic Efficacy of Maxigesic in Breast Cancer Surgery
The present study aims to find a perioperative analgesic method that provides sufficient analgesia while reducing immune compromise in cancer surgery. This study is to investigate the analgesic effect and safety of Maxigesic inj.
- Trial name
- NCT06174363
- Testing
- Maxigesic, 0.9% saline solution
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Male Breast Cancer, Recurrent Melanoma
Propranolol Hydrochloride in Treating Patients With Locally Recurrent or Metastatic Solid Tumors That Cannot Be Removed By Surgery
This pilot trial studies propranolol hydrochloride in treating patients with locally recurrent or metastatic solid tumors that cannot be removed by surgery.
- Conditions
- Male Breast Cancer, Recurrent Melanoma, Stage IV Breast Cancer, Stage IV Melanoma
- Trial name
- NCT02013492
- Testing
- propranolol hydrochloride, Correlative Studies
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- William Carson
Breast Cancer
Letrozole in Treating Postmenopausal Women With Stage I, II or III Breast Cancer That Can Be Removed by Surgery
RATIONALE: Hormone therapy using letrozole may fight breast cancer by lowering the amount of estrogen the body makes. Giving letrozole before surgery allows us to monitor the effects of letrozole on the tumor on a molecular level…
- Trial name
- NCT00651976
- Testing
- letrozole, Blood Collection, biopsy/lumpectomy/mastectomy
- Where
- 5 sites in United States
- Volunteers
- 213 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Women With Early Breast Cancer, Breast Conserving Surgery
Health Status of Women With Breast Cancer
The quality-adjusted life-year (QALY) is the outcome measure of choice in England and Wales for National Institute for Health and Care Excellence (NICE). To be able to conduct a cost utility analysis, QALY data is required.
- Conditions
- Women With Early Breast Cancer, Breast Conserving Surgery, Radiotherapy
- Trial name
- OSTaRa (NCT03761940)
- Testing
- EQ5D questionnaire and a demographic questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Breast Cancer
Perillyl Alcohol in Preventing Recurrent Breast Cancer in Women Who Have Been Treated With Surgery With or Without Adjuvant Therapy
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the recurrence of cancer. The use of perillyl alcohol may be effective in preventing the recurrence of breast cancer.
- Trial name
- NCT00022425
- Testing
- perillyl alcohol
- Where
- United States
- Sponsor
- The Cleveland Clinic
Breast Cancer, Lymphocele
Efficacy Study of Ifabond in Breast Cancer Surgery
A randomized prospective simple-blind interventional study evaluating the efficacy of the synthetic adhesive solution "Ifabond", in patients undergoing breast cancer surgery.
- Trial name
- Ifabond (NCT01742975)
- Testing
- IFABOND (TM)
- Where
- 2 sites in France
- Volunteers
- 104 people
- Sponsor
- Hôpital Européen Marseille
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