Clinical trials: Surgery of Breast Cancer
Breast Cancer
A Randomized Trial of Chemotherapy in Surgical Patients With Infiltrating Ductal Carcinoma of Breast
The overarching purpose of this study is to determine if the mainstay chemotherapeutic regimens represented by several genotoxic agents including but not limited to Cyclophosphamide, Doxorubicin, Epirubicin, Fluorouracil and…
- Trial name
- COC-IDCB (NCT02897700)
- Testing
- Single agent of cyclophosphamide, doxorubicin, epirubicin, fluorouracil and methotrexate, cyclophosphamide, doxorubicin, epirubicin, fluorouracil and methotrexate (CDEFM)
- Where
- 3 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
HER2/Neu Positive, Stage IA Breast Cancer
Combination Chemotherapy and Paclitaxel Plus Trastuzumab in Treating Women With Palpable Breast Cancer That Can Be Removed by Surgery
This randomized phase III trial is studying giving fluorouracil together with epirubicin and cyclophosphamide followed by paclitaxel and trastuzumab to see how well it works compared with giving paclitaxel together with…
- Conditions
- HER2/Neu Positive, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT00513292
- Testing
- Cyclophosphamide, Epirubicin Hydrochloride, Laboratory Biomarker Analysis
- Where
- 115 sites in United States, Puerto Rico
- Volunteers
- 280 people
- Sponsor
- National Cancer Institute (NCI)
Other Reconstructive Surgery, Failure of Muscle Graft
Robotic Harvest of the Latissimus Dorsi (LD) Muscles
The goal of this clinical research study is to learn more about the safety and feasibility of using the Da Vinci Robotic Surgical system in procedures that harvest the latissimus dorsi muscle (a back muscle below your shoulder)…
- Conditions
- Other Reconstructive Surgery, Failure of Muscle Graft, Cancer, Complications
- Trial name
- NCT02274493
- Testing
- da Vinci® Robotic Surgical System, LD muscle flap harvest procedure, Reconstructive surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm
Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery.
- Conditions
- Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm, Mammoplasty Patient, Obesity
- Trial name
- NCT04003038
- Testing
- Negative Pressure Wound Therapy, Wound Care Management
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Breast Neoplasms
Pectoral Nerve Block Type-II and Rhomboid Intercostal Block for Pain Management Following Mastectomy Surgery
Postoperative pain is an important issue in patients underwent mastectomy and axillary dissection surgery. Postoperative effective pain treatment provides early mobilization and shorter hospital stay.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Diseases, Breast Fibroadenoma
- Trial name
- NCT04297007
- Testing
- PECS block, Rhomboid intercostal block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Breast Cancer Patients With Chronic Pain After Surgery
Effect of Bupivacaine Liposome Anterior Serratus Deep Block on Chronic Pain After Breast Cancer Surgery: a Randomized Controlled Study
This study aims to investigate the effect and influence of liposome bupivacaine anterior serrat plane block on postoperative chronic pain in breast cancer patients, evaluate the therapeutic effect of liposome bupivacaine in…
- Trial name
- NCT06427044
- Testing
- Anterior serratus block group
- Where
- China
- Volunteers
- 143 people
- Sponsor
- Lu Hua
Lymphedema, Lymphedema of Upper Arm
Microvascular Breast Reconstruction With Lymph Node Transfer
this study aims to evaluate the outcomes of simultaneous free abdominal flap \& vascularized lymph node transfer for both breast reconstruction and postmastectomy lymphedema
- Conditions
- Lymphedema, Lymphedema of Upper Arm, Mastectomy; Lymphedema
- Trial name
- NCT04246034
- Testing
- Microvascular Breast Reconstruction with Vascularized Lymph Node Transfer
- Sponsor
- Assiut University
Postoperative Pain, Quality of Recovery
Quality Study of Anesthetic Technique on Breast Cancer Surgery
Previous studies have shown that paravertebral block (PVB) has the potential to reduce pain and side effects after breast surgery when used in addition to general anesthesia or sedation.The investigators would like to further…
- Conditions
- Postoperative Pain, Quality of Recovery, Satisfaction
- Trial name
- PQSAT (NCT01499836)
- Testing
- PVB
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Nai Liang Li
Breast Cancer
The Use of a High-frequency Ultrasonic Knife in Breast Cancer Surgery
Background: Lymphatic stasis and seroma formation are common complications of axillary lymphadenectomy in breast cancer surgery.
- Trial name
- UKBC (NCT00996632)
- Testing
- ultrasonic knife (Ultracision®, Ethicon Endo Surgery), conventional diarthermy knife
- Where
- 2 sites in Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Persistent Postoperative Pain
Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery
This study will test the benefits and risks of using pregabalin perioperatively to prevent persistent postoperative pain in patients at high risk (>30%) of developing such pain after breast cancer surgery.
- Trial name
- PREVENT (NCT03216187)
- Testing
- Pregabalin
- Where
- 6 sites in Switzerland
- Volunteers
- 126 people
- Sponsor
- Benno Rehberg-Klug
Breast Cancer, Complication of Surgical Procedure
Feasibility Study to Evaluate the Use of Patient Reported Complications After Digital Consent
Patient report complication data to our best knowledge has not been studied yet in electronic consent. This study is a feasibility study to assess whether patients will reliably report their complications, the quality of this…
- Trial name
- PRC (NCT06351865)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Pain Threshold
Chronic Pain After Operation for Breast Cancer
The purpose of this study is to identify intraindividual as well as iatrogenic factors disposing for the development of chronic and acute pains after surgery for breast cancer in order to improve treatment and prevent the…
- Trial name
- NCT00739544
- Testing
- 1
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer, Neutropenia
Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer
RATIONALE: Colony-stimulating factors, such as filgrastim or pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of…
- Trial name
- NCT00030758
- Testing
- filgrastim, pegfilgrastim
- Where
- 32 sites in United Kingdom
- Volunteers
- 816 people
- Sponsor
- Anglo Celtic Cooperative Oncology Group
Mastectomy, Rhomboid Intercostal Block
Effects of Rhomboid Intercostal Block on Postoperative Pain Management and Chronic Pain Incidence in Mastectomies
The goal of this clinical trial is to evaluate the effects of the Rhomboid Intercostal Block (RIB) on postoperative chronic pain prevalence at 3 months (primary outcome) and on acute pain control, total opioid consumption, and…
- Conditions
- Mastectomy, Rhomboid Intercostal Block, Chronic Pain Following Surgical Procedure for Cancer
- Trial name
- NCT06756048
- Testing
- Rhomboid Intercostal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Koç University
Breast Cancer, Prostate Cancer
Kinetics of Perioperative Circulating DNA in Cancer Surgery
The aim of this study was to determine the kinetics of perioperative circulating DNA in three types of cancer. This first step will enable further studies comparing the potential impact of certain techniques or anesthetic…
- Conditions
- Breast Cancer, Prostate Cancer, Colon Cancer
- Trial name
- Periop ctDNA (NCT03284684)
- Testing
- Blood test
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Breast Cancer Patients
Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block in Breast Cancer Patients
To Evaluate the effect of addition of Dexmedetomedine to ultrasound guided modified Pecs block on post operative analgesia \& stress response in patient undergoing modified radical mastectomy.
- Trial name
- NCT03046238
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Breast Cancer Female
Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?
The Neutrophil to Lymphocyte Ratio (NLR) is a frequently used biomarker of the systemic inflammatory response and is considered one of the most sensitive markers of inflammation.
- Trial name
- NCT04172220
- Testing
- Midazolam, PECS, Opioid-free general anesthesia
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Breast Cancer, Breast Surgery
Breathing Interventions for Postoperative Breast Surgery Patients
This randomized controlled trial aims to evaluate the effects of pranayama and pursed-lip breathing exercises on postoperative pain, anxiety, and vital signs in patients undergoing breast surgery.
- Conditions
- Breast Cancer, Breast Surgery, Postoperative Pain, Anxiety
- Trial name
- BREATH-RCT (NCT07449273)
- Testing
- Pranayama Breathing Exercise, Pursed-Lip Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Ondokuz Mayıs University
Breast Cancer
Exemestane or Anastrozole in Treating Postmenopausal Women Who Have Undergone Surgery for Primary Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy, using exemestane or anastrozole, may fight breast cancer by reducing the production of estrogen.
- Trial name
- NCT00066573
- Testing
- anastrozole, exemestane
- Where
- 39 sites in Canada
- Volunteers
- 7,576 people
- Sponsor
- NCIC Clinical Trials Group
Breast Carcinoma, Cancer Survivor
Supportive Care Questionnaires in Gathering Data on Unmet Needs and Health-Related Quality of Life in Latina Breast Cancer Survivors After Surgery, Chemotherapy, or Radiation Therapy
This phase I/II research trial studies supportive care questionnaires in gathering data on unmet needs and health-related quality of life in Latina breast cancer survivors after surgery, chemotherapy, or radiation therapy.
- Trial name
- NCT02545023
- Testing
- Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California