Clinical trials: Surgery of Breast Cancer
Breast Neoplasms
Safety and Effectiveness Study of Single-Port Surgical System in Breast Tumor Surgery
This is a prospective, multicenter clinical study designed to evaluate the safety and effectiveness of remote surgery using the single-port thoracoabdominal endoscopic surgical system in breast tumor surgery.
- Trial name
- NCT07879963
- Testing
- Robotic-assisted breast tumor surgery, Single-port surgical system operation
- Volunteers
- 25 people
- Sponsor
- haiyanli
Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm
PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of PI3Kbeta inhibitor AZD8186 when given together with docetaxel in treating patients with solid tumors with PTEN or PIK3CB mutations that have spread to other places in…
- Conditions
- Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Prostate Carcinoma, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03218826
- Testing
- Docetaxel, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- National Cancer Institute (NCI)
Breast Neoplasms, Mastectomy, Segmental
Acellular Dermal Matrix(SureDerm BCS) in Breast-Conserving Surgery for Breast Cancer Patients
The goal of this clinical trial is to evaluate whether the use of an acellular dermal matrix (SureDerm) can improve cosmetic satisfaction and is safe in women with breast cancer undergoing breast-conserving surgery.
- Trial name
- NCT07345026
- Testing
- Acellular Dermal Matrix (SureDerm BCS), Standard Breast-Conserving Surgery
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Seoul St. Mary's Hospital
Breast Cancer, Chemotherapy Effect
Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer
Introduction: Neoadjuvant chemotherapy (NACT) has been the standard therapy for treating patients with locally advanced breast cancer (LABC). Doxorubicin-based regimen showed a clinical response for 70-80%.
- Trial name
- NCT04418089
- Testing
- Simvastatin 40mg
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Pain Management After Major Breast Surgery, Well Being After Major Breast Surgery
Quality of Recovery After Primary Breast Cancer Surgery Comparing Thoracic Paravertebral Block and Intravenous Lidocaine Infusion.
The goal of this clinical trial is to learn whether an intravenous lidocaine infusion (IVLI) works as well as a thoracic paravertebral block (TPVB) - the current standard nerve-block technique - for improving recovery after…
- Trial name
- NCT07823244
- Testing
- TPVB, IV Lidocaine infusion
- Where
- Thailand
- Volunteers
- 112 people
- Sponsor
- Mahidol University
Breast Carcinoma Metastatic in Lymph Node, Stage II Breast Cancer AJCC v6 and v7
Magseed Magnetic Marker in Locating Axillary Lymph Nodes in Patients With Breast Cancer Undergoing Surgery
This phase IV trial studies the side effects of the Magseed magnetic marker and how well it works in locating lymph nodes in the underarm area in patients with breast cancer undergoing surgery.
- Conditions
- Breast Carcinoma Metastatic in Lymph Node, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7
- Trial name
- NCT03038152
- Testing
- Axillary Lymph Node Dissection, Localization, Medical Device
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Neoplasms
A Prospective Study of Preoperative Tumor-bed Boost Followed by Oncoplastic Surgery and Adjuvant Whole Breast Radiotherapy for Early Stage Breast Cancer (BIRKIN)
This study explores the feasibility of preoperative single-dose tumor-bed boost followed by oncoplastic breast-conserving surgery and ultra-hypofractionated postoperative radiotherapy in patients with early stage breast cancer.
- Trial name
- BIRKIN (NCT05603078)
- Testing
- Preoperative MRI-guided tumor-bed boost and postopreative ultra-hypofractionated radiotherapy (26 Gy/5.2Gy/5)
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Persistent Post-surgical Pain, Neuropathic Pain
Development of a Personalised Care Plan Designed to Reduce Chronic Post-Operative Pain Following Breast Surgery
Numerous surveys have shown that following breast surgery, longterm pain affects around half of patients. Given that 1 in 9 women will get breast cancer and that surgery is the cornerstone of treatment, persistent pain represents…
- Conditions
- Persistent Post-surgical Pain, Neuropathic Pain, Cancer Pain
- Trial name
- NCT02170415
- Testing
- Protective analgesia, Pain education, Psychological support
- Where
- United Kingdom
- Volunteers
- 154 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer, Pain, Acute
ESP in Breast Surgery Due to Cancer
Patients scheduled for breast surgery due to cancer. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Conditions
- Breast Cancer, Pain, Acute, Anesthesia, Local
- Trial name
- NCT04726878
- Testing
- Erector spinae plane block, General anesthesia, Patient-controlled analgesia
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Medical University of Lublin
Breast Cancer
Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Ductal Carcinoma In Situ of the Breast
RATIONALE: Vaccines made from peptides and a person's white blood cells may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00107211
- Testing
- therapeutic autologous dendritic cells, conventional surgery, neoadjuvant therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer
Wide Field OCT + AI for Positive Margin Rates in Breast Conservation Surgery.
This is a multi-center, randomized, two-arm study designed to measure the effectiveness of the SELENE system in reducing the number of unaddressed positive margins in breast lumpectomy procedures when used in addition to standard…
- Trial name
- RCT (NCT05113927)
- Testing
- Selene
- Where
- 10 sites in United States
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Perimeter Medical Imaging
Breast Cancer, Exercise
The Effect of a Post-operative Exercise Programme Versus Standard Care on Physical Fitness of Patients With Breast Cancer Undergoing Deep Inferior Epigastric Perforator (DIEP) Flap Reconstruction Surgery
All patients undergoing mastectomy for breast cancer should be offered the option of reconstructive surgery. The Deep Inferior Epigastric Perforator Flap or DIEP reconstruction as it is commonly referred to, is becoming the…
- Trial name
- EXERCISE DIEP (NCT07672392)
- Testing
- Structured individualised 12-week post operative exercise programme
- Where
- Ireland
- Volunteers
- 78 people
- Sponsor
- Royal College of Surgeons, Ireland
Bone Metastases
ExAblate Conformal Bone System Treatment of Metastatic Bone Tumors for the Palliation of Pain
A study to evaluate the safety and initial effectiveness of the ExAblate 2100 Conformal Bone System in the treatment of pain resulting from metastatic bone tumors.
- Trial name
- NCT00981578
- Testing
- ExAblate 2100
- Where
- 5 sites in United States
- Volunteers
- 37 people
- Sponsor
- InSightec
Triple-Negative Breast Cancer
Study of Magrolimab Combination Therapy in Patients With Non-Surgically Removable Locally Advanced or Metastatic Triple-Negative Breast Cancer
The goals of this clinical study are to learn about the safety, tolerability, dosing and effectiveness of magrolimab in combination with nab-paclitaxel or paclitaxel (cohort 1) or with sacituzumab govitecan-hziy (cohort 2) in…
- Trial name
- ELEVATE TNBC (NCT04958785)
- Testing
- Magrolimab, Nab-Paclitaxel, Paclitaxel
- Where
- 45 sites in United States, Australia and 4 more
- Volunteers
- 92 people
- Sponsor
- Gilead Sciences
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Radiation Therapy Boost Before Surgery for the Treatment of Non-metastatic Breast Cancer
This phase II trial investigates the safety of delivering a part (boost) of radiation treatment before breast surgery in treating patients with breast cancer that has not spread to other places in the body (non-metastatic).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04871516
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Boost
- Where
- 11 sites in United States
- Volunteers
- 103 people
- Sponsor
- Rutgers, The State University of New Jersey
Breast Carcinoma
Acceptability of 3D Printed Breast Models as Surgical Decision Aids for Breast Cancer Treatment
This study is to find out the acceptability of a 3D printed breast model by patients as they consider their surgical treatment options.
- Trial name
- NCT04693364
- Testing
- Decision Aid, Discussion, Questionnaire Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Physical Activity, Breast Neoplasm
The Impact of Physical Activity on the Outcome of Surgery
Over the last decades different life style factors have been established as risk factors for various diseases. The obesity pandemic displays a good example of a disease where great effort is undertaken to characterize risk…
- Conditions
- Physical Activity, Breast Neoplasm, Colorectal Neoplasm, Gall Stones
- Trial name
- NCT01707121
- Where
- 2 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Sahlgrenska University Hospital
Breast Cancer
Reconstruction of Partial Mastectomy Defects With Pectoralis Myo-glandular Local Flap.
Increasing number of breast cancer patients are being treated with conservative surgery; without the need for mastectomy. The cosmetic sequel of breast conservative surgery can be unsatisfactory to the patient and may necessitate…
- Trial name
- NCT04091958
- Testing
- Pectoralis myo-glandular flap reconstruction.
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Breast Cancer, HER2-negative Breast Cancer
A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Lobular Breast Cancer
The purpose of this study is to look at how effective neoadjuvant (before surgery) endocrine therapy (NET) is in participants with invasive lobular carcinoma (ILC) who have breast-conserving surgery (BCS).
- Conditions
- Breast Cancer, HER2-negative Breast Cancer, HER2 Negative Breast Carcinoma, ER+ Breast Cancer
- Trial name
- NCT07483307
- Testing
- Neoadjuvant endocrine therapy
- Where
- 7 sites in United States
- Volunteers
- 176 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00881361
- Testing
- systemic chemotherapy, axillary lymph node dissection, neoadjuvant therapy
- Where
- 324 sites in United States
- Volunteers
- 756 people
- Sponsor
- Alliance for Clinical Trials in Oncology
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