Clinical trials: Surgical Margin
Posterior Blepharoconjunctivitis
A Four Week, Open-Label Study of Azithromycin Ophthalmic Solution, 1% (P08641)
One objective of this study is to determine the levels of markers of inflammation on the eyelid margin of subjects with blepharoconjunctivitis and compare them with those of healthy volunteers.
- Trial name
- NCT01220258
- Testing
- Azithromycin ophthalmic solution, 1%
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Esophageal Squamous Cell Carcinoma, Positive Circumferential Resection Margin
Adjuvant Radiotherapy for Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin
The purpose of this study is to determine the efficacy of adjuvant radiotherapy for esophageal squamous cell carcinoma with positive circumstantial resection margin.
- Trial name
- NCT03273647
- Testing
- radiation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fudan University
DME, Dental Caries
The Effect of Bulk Filling Flowable Composite on Caries Recurrence in Deep Marginal Elevation: A Randomized Clinical Trial
Deep marginal elevation usinge a bioactive dental material in deep subgingival Class II restorations, S-PRG filler-containing materials offer significant benefits due to their bioactive properties, Their ability to release…
- Conditions
- DME, Dental Caries, Dental, Deep Margin Elevation
- Trial name
- NCT06900868
- Testing
- Assigned Interventions
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Implant, Tooth Loss
Flap Vs Flapless Technique for Delayed Implant Placement in the Maxillary Esthetic Zone
This randomized comparative clinical trial aims to evaluate the clinical, radiographic, and esthetic outcomes of flap versus flapless techniques for delayed dental implant placement in the maxillary esthetic zone.
- Conditions
- Dental Implant, Tooth Loss, Partial Edentulism, Maxillary Tooth Loss
- Trial name
- NCT07654452
- Testing
- Flap Implant Placement, Flapless Implant Placement
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Endodontically Treated Teeth, Missing Teeth
Impression & Prosthesis Quality Made From Different Polyvinylsiloxane Impression Techniques
This randomized controlled trial is to clinically assess and compare impression quality of polyvinylsiloxane impression material using one step (experimental) and two step (control) impression techniques and its effect on…
- Conditions
- Endodontically Treated Teeth, Missing Teeth, Discoloration, Tooth, Prosthesis Failure, Dental
- Trial name
- NCT05938400
- Testing
- Polyvinylsiloxane impression with different techniques
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Dental Implants
In the Treatment of Implants With Different Methods; Early Bone Loss and Patient Satisfaction
The aim of this clinical study is to compare two different approaches during dental implant applications. One group of patients in the study received flapless approach which is performed without surgical reflection of soft…
- Trial name
- NCT04459494
- Testing
- Flapless implant surgery., Conventional implant surgery.
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Prosthesis User, Digitalism
"Clinical Evaluation of Retraction Cord Effectiveness Using Intraoral Scanner
Dental-supported fixed partial dentures (FPDs) have long been a commonly preferred treatment method for the rehabilitation of teeth with excessive substance loss and for addressing existing tooth deficiencies.
- Trial name
- NCT06447389
- Testing
- retraction cordu (SURE-CORD®PLUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Retroperitoneal Sarcoma, Margin, Tumor-Free
Retroperıtoneal Soft-Tıssue Sarcomas
: Soft Tissue Sarcomas are rare mesenchymal tumors with many subtypes. Clean margin-wide resection is recommended for treatment. The guidelines recommend that sarcoma treatments be carried out in sarcoma centers.
- Trial name
- NCT05044624
- Testing
- retroperitoneal mass excision
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Pancreatic Cancer, Adult, Margin, Tumor-Free
Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
This study is aimed to evaluate difference of the 2 year recurrence free survival after pancreaticoduodenectomy for pancreatic cancer between artery-first approach and conventional procedure groups.
- Conditions
- Pancreatic Cancer, Adult, Margin, Tumor-Free, Surgery Site Fistula, Recurrence Tumor
- Trial name
- NCT04136522
- Testing
- conventional pancreaticoduodenectomy, total mesopancreas excision including superior mesenteric artery first approach
- Where
- South Korea
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Gingival Margin Elevation
Effect of Different Base Materials on Ginigiva During Gingival Margin Elevation
This study will be conducted to investigate 1. The effect of deep margin elevation with different base materials (resin modified glass ionomer, flowable composite, injectable hybrid composite) on fracture resistance and marginal…
- Trial name
- NCT06944080
- Testing
- base material(Tetric® N-Flow,Beautifil-Flow PLUS,GC fuji II LC capsule)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Minia University
Gingival Recession, Localized
Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
The aim of this randomized, parallel-group clinical trial was to compare the 1-year periodontal, root coverage, esthetic, and patient-centered outcomes of the partial restoration placement with different apical margin levels…
- Trial name
- NCT05682274
- Testing
- Partial restoration approach combined with CAF+CTG
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Breast Cancer
Margin Optimisation Using Z-axis Assessment With Real-time Tomosynthesis (MOZART Study).
Breast-conserving surgery is commonly performed to remove early-stage breast cancer or ductal carcinoma in situ (DCIS). During surgery, the goal is to completely remove the tumour with a clear margin of normal tissue around it.
- Trial name
- MOZART (NCT07426809)
- Testing
- Standard 2D Specimen Mammography, Mozart 3D Specimen Radiography System
- Where
- Ireland
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Blepharitis
Short-term Effects on Tear Film (Baby Shampoo vs Blephasol)
Lid cleansing is the standard regime that is recommended for the management of blepharitis in the UK and beyond. Whilst many successful commercial preparations exist, and some with clinical evidence, professional guidelines (UK…
- Trial name
- Blepha (NCT04858113)
- Testing
- Blephaclean
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Healthy Volunteers, Dynamic Stability Margin
Normative Dynamic & Magnetic Spine
This study aims to describe normal spinal musculoskeletal patterns in healthy adolescents and young adults by using static and dynamic measures.
- Conditions
- Healthy Volunteers, Dynamic Stability Margin, Gait, Paraspinal Muscles
- Trial name
- NDMS (NCT03125434)
- Testing
- EOS full-spine, MRI, gait analysis
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Surgical Anastomosis
Intraoperative Hyperspectral Imaging in Gastrointestinal Anastomoses
In this study, gastrointestinal anastomoses are examined with a hyperspectral camera.
- Trial name
- HSIGI (NCT03667950)
- Testing
- Hyperspectral Imaging
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Breast Cancer
Wide Field OCT + AI for Positive Margin Rates in Breast Conservation Surgery.
This is a multi-center, randomized, two-arm study designed to measure the effectiveness of the SELENE system in reducing the number of unaddressed positive margins in breast lumpectomy procedures when used in addition to standard…
- Trial name
- RCT (NCT05113927)
- Testing
- Selene
- Where
- 10 sites in United States
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Perimeter Medical Imaging
Patient Comfort, Malocclusion
Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study
The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives…
- Conditions
- Patient Comfort, Malocclusion, Oral Health
- Trial name
- COMFORT-ALIGN (NCT07660809)
- Testing
- Supragingival trimming-line design, Juxtagingival festooned trimming-line design
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Gingivitis
Influence of the Restorative Cervical Margin Placement on the Supracrestal Tissue Attachment
The aim of the present study is to understand the influence that marginal/subgingival restorations exert on the surrounding periodontal tissues.
- Trial name
- NCT04299347
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Siena
Altered Passive Eruption of Teeth
The Effect of Using Two Different Suturing Techniques on Free Gingival Marginal Stability
Gummy smile is one of the major esthetic problems nowadays; it is due to several causes that either dental or skeletal. Etiology of the gummy smile is altered passive eruption, vertical maxillary excess, different gingival…
- Trial name
- NCT04219436
- Testing
- vertical mattress suturing technique, figure of eight suturing technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
DME, Dental
Clinical Performance of High Viscosity Bioactive Injectable Composite in Deep Marginal Elevation
Using a bioactive resin composite in subgingival Class II cavities can provide enhanced caries resistance by releasing multiple ions, including fluoride.
- Conditions
- DME, Dental, Deep Margin Elevation
- Trial name
- Randomized (NCT06875544)
- Testing
- Beautifil F00, G-aenial Universal Injectable Flowable Composite
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt