Clinical trials: Surgical Margin
Pediatric Radiation
Planning Margin Requirements for Pediatric Radiation Oncology
The planning target volume (PTV) and planning organ at risk volume (PRV) margins used for pediatric radiation therapy are empiric, and quantitative assessment of these margins is needed to improve therapy planning and delivery.
- Trial name
- NCT00704613
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- St. Jude Children's Research Hospital
Gingival Recession
Manual Versus Oscillating-rotating Toothbrushes After Root Coverage Procedure
The aim of this study is to evaluate the gingival margin stability with the use of oscillating-rotating toothbrushes compared to manual toothbrushes.
- Trial name
- NCT02534220
- Testing
- Manual Toothbrush, Oscillating-rotating toothbrush
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Milan
Gingival Recession, Periodontal Atrophy
Comparison Between Two Coronally Positioned Flap With Connective Tissue
The aim of this study is to evaluate the effectiveness of total root coverage between two coronally positioned flap technique in Miller recession Class I and II, in patients attending at "Universidad El Bosque" dental school…
- Trial name
- NCT01814592
- Testing
- coronally partial thickness flap plus connective tissue, coronally mucosal thickness flap
- Where
- Colombia
- Volunteers
- 72 people
- Sponsor
- Universidad El Bosque, Bogotá
Rectal Cancer, Rectal Adenocarcinoma
Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology
This innovative study will involve the use of probe-based confocal laser endomicroscopy, a new medical imaging technology never used for surgical indications to date.
- Trial name
- TRaMA (NCT01887509)
- Testing
- Probe-based confocal laser endomicroscopy, Rectoscopy, EUS
- Where
- France
- Volunteers
- 21 people
- Sponsor
- IHU Strasbourg
Colo-rectal Cancer
Safety & Efficacy of a Novel Asymmetrical Linear Stapler (NALS) for Securing Distal Resection Margin in Laparoscopic Rectal Cancer Surgery: Pilot Study
Through the use of a novel asymmetrical linear stapler (NALS, Meditulip co. Ltd.), we aim to prove that true distal margins greater than 1cm may be harvested more readily and easily compared to the conventional staplers.
- Trial name
- NCT06709170
- Testing
- Novel asymmetrical linear stapler, Signia™
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Prostate Cancer
Ex-vivo Investigation of Beta Probe for Prostate Cancer Resection and Evaluation of PSMA-PET for Diagnosis of Intraprostatic Lesions
68Ga-PSMA is a radiopharmaceutical used with PET imaging for the detection of prostate cancer under a compassionate IND in patients who have presented with biochemical failure.
- Trial name
- NCT03213951
- Testing
- Experimental beta probe, PSMA-PET
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Esophageal Squamous Cell Carcinoma
Radiotherapy Target Volume in Locally Advanced Esophageal Squamous Cell Carcinoma in the Immunotherapy Era
This retrospective real-world cohort study will evaluate the efficacy and safety of different radiotherapy target volume extents in patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT07879898
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Skin Cancer
Optical Imaging of Skin Cancers for Margin Delineation of Non-Melanoma Skin Cancers
The goal of this clinical research study is to evaluate an experimental imaging technology, the multispectral digital microscope (MDM), which may help doctors see how far skin cancer extends (widens out) on an area of skin.
- Trial name
- NCT00432471
- Testing
- Optical Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Irregular; Contour of Cornea, Keratoconus
Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders
The most common causes for irregular cornea (IC) in hospital contact lens practice are Keratoconus (KC) and related cornea thinning disorders.
- Conditions
- Irregular; Contour of Cornea, Keratoconus, Pellucid Marginal Corneal Degeneration, Injury of Cornea
- Trial name
- NCT02444923
- Testing
- Scleral rigid gas permeable contact lenses (SRGPcl) (Zenlens™), Corneal Rigid gas Permeable contact lenses (CRGPcl) (Rose K2)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- London South Bank University
Squamous Cell Carcinoma of Head and Neck, Neoadjuvant Therapy
Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced HNSCC
This study aims to explore the 2-year DFS (disease-free survival) rate and organ retention rate and to explore the ORR, PCR rate, 2y-OS， and quality of life of patients.
- Conditions
- Squamous Cell Carcinoma of Head and Neck, Neoadjuvant Therapy, Resection Margin
- Trial name
- NCT05459415
- Testing
- Reducing Excision Margins
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Cancer
LightPathTM Imaging System for Ex-vivo Assessment of Margin and Lymph Node Status in Breast Cancer Surgical Specimens
This study is a prospective, cross-sectional observational single centre study to assess the feasibility of intra-operative Cerenkov Luminescence Imaging (CLI) of breast cancer wide local excision (WLE) specimens and dissected…
- Trial name
- NCT02037269
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Lightpoint Medical Limited
Colon Cancer
Non-microradical Resection Margin as a Predictor for Recurrence After Complete Mesocolic Excision
The study aim to investigate the value of the current definition of microradical resection margin in colon cancer. Is the distance from tumor tissue to resection margin and the site of any clinically prognostic importance if…
- Trial name
- NCT04395534
- Testing
- Complete mesocolic excision
- Volunteers
- 276 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
Melanoma, Surgery
Trial of Surgical Excision Margins in Thick Primary Melanoma - 2
Objectives: The purpose of this study was to assess the long-term follow-up of the overall and melanoma-specific survival in the randomised, open-lable multicenter trial (NTC NCT01183936) comparing excision margin of 2 cm versus…
- Conditions
- Melanoma, Surgery, Treatment Outcome
- Trial name
- NCT03638492
- Testing
- 2-cm margin, 4-cm margin
- Volunteers
- 936 people
- Sponsor
- Peter Gillgren
Breast Cancer, Head and Neck Cancers
Surgical Margin Assessment Using Intra-operative High-resolution PET/CT in Patients With Cancers Referred to Surgical Resection, an Exploratory Pilot Study
Reoperation is often required in surgical oncology because of positive resection margins and is associated with substantial physical, psychological, and economic consequences.
- Conditions
- Breast Cancer, Head and Neck Cancers, Lung Cancer, Sarcoma
- Trial name
- SMART-PET (NCT07884487)
- Testing
- FDG radiotracer
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Dental Implants, Peri-Implantitis
Increased Peri-implant Keratinized Mucosal Thickness at Different Operative Times
Keratinized mucosa, which is composed of free gingiva and attached gingiva, is a barrier against bacterial invasion in oral cavity and provides good tissue sealing for periodontal environment.
- Trial name
- NCT04683991
- Testing
- Subepithelial connective tissue graft
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Metastases, Adult, Brain Tumor - Metastatic
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation…
- Conditions
- Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT07132190
- Testing
- Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ayal A. Aizer, MD
Marginal Ulcers
Ulcer Prevention Study in Post Gastric Bypass Patients
This research is to determine which medication, Zegerid (Omeprazole/Sodium Bicarbonate) or Pepcid AC (Famotidine), works best at reducing the chance that a patient will get an ulcer after gastric bypass surgery.
- Trial name
- NCT00557349
- Testing
- Omeprazole, Famotidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Ameloblastoma
Virtual Lesion Segmentation and Mandibular Ameloblastoma Radiographic Safety Margin
Reconstruction of segmental mandibular defects is in a continuous state of evolution utilizing the recent advances in Computer-Aided Designing (CAD) and preoperative Virtual Surgical Planning (VSP).
- Trial name
- NCT07306962
- Testing
- Virtual lesion segmentation for mandibular ameloblastoma
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Alexandria University
Pancreatic Cancer
Margin-Intense Combo Therapy in Pts w/Potentially Resectable Pancreatic Cancer
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue.
- Trial name
- NCT01025882
- Testing
- gemcitabine hydrochloride, stereotactic body radiation therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Texas Southwestern Medical Center
Colorectal Cancer, Polyp of Colon
Hybrid-APC Margin Ablation to Prevent Post EMR Adenoma Recurrence
Endoscopic Mucosal Resection (EMR) is the current standard for effective endoscopic resection of such colon adenomas. If resection is possible in one piece (so-called "en bloc" resection) then recurrence rates are low.
- Trial name
- h-APC_EMR (NCT04015765)
- Testing
- Hybrid Argon Plasma Coagulation and EMR procedure
- Where
- Canada
- Volunteers
- 376 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)