Clinical trials: Surveillance
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women in Real World
Community Study to Increase Mammogram Screening Among Overdue Women
Breast cancer is the most common cancer among women in Singapore, and regular mammogram screening can detect breast cancer early when treatment is more effective.
- Trial name
- IMPLEMENT (NCT07832396)
- Testing
- Evidence-based behavioural intervention
- Where
- Singapore
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Thyroid Cancer, Active Surveillance
Patients With a Single, Small (2 cm or Less) Cancer Nodule in the Thyroid Gland Will be Offered Active Surveillance Initially for 5 Years. In Case of Cancer Growth or Changes in Ultrasonographic Appearance, Further Treatment Will be Offered.
Patients with a single, small (less than 2 cm) cancer nodule in the thyroid gland will be offered active surveillance initially for 5 years.
- Trial name
- NCT07822217
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Prostate Cancer, Prostatic Neoplasm
Dietary Fibre Supplementation to Delay Disease Progression in Early Prostate Cancer
This qualitative research study, based on semi-structured interviews and a focus group, aims to explore the attitudes of prostate cancer patients on active surveillance (AS) towards dietary fibre supplementation, given the…
- Conditions
- Prostate Cancer, Prostatic Neoplasm, Dietary Fibre Modification, Active Surveillance
- Trial name
- DEFINITE (NCT07790003)
- Testing
- Qualitative semi-structured interviews, Focus group
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Aberdeen
Colorectal Neoplasms, Colorectal Cancer Prevention
ULTRA-high-risk Surveillance to Avoid Future Events: the ULTRA-SAFE Trial
The ULTRA-SAFE clinical trial is a prospective, randomized study designed to address the limitations of current "one-size-fits-all" colorectal cancer surveillance guidelines.
- Conditions
- Colorectal Neoplasms, Colorectal Cancer Prevention, Surveillance Colonoscopy
- Trial name
- ULTRA-SAFE (NCT07378930)
- Testing
- Early triage using Fecal immunochemical test
- Where
- 4 sites in Taiwan
- Volunteers
- 940 people
- Sponsor
- National Taiwan University Hospital
Immune Surveillance
Acute Immune Modulation by Probiotic Strain
Clinical proof-of-concept study, comparing the acute immune impacts of 3 doses of a probiotic strain to a placebo. This study involves twenty-four participants, composed of healthy adults, who will be taking a placebo and 3…
- Trial name
- NCT06754228
- Testing
- Probiotic Agent
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC)
Narrow Band Imaging Versus Artificial Intelligence for Colonic Surveillance in Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) - ulcerative colitis or Crohn's disease - have a higher risk of developing colorectal cancer than the general population.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC), Crohn's Disease Colon, Colonic Dysplasia/Adenomata
- Trial name
- CLEAR-IBD (NCT07694362)
- Testing
- ENDO-AID CADe System (Olympus, Tokyo, Japan) (AI device)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vall d'Hebron Institute Research
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women
Trial to Evaluate the Impact of Various Interventions to Increase the Uptake of Surveillance Mammography in Eligible Women in Singapore
Breast cancer is the most common cancer among women in Singapore, with more than 70 women out of every 100,000 being diagnosed each year.
- Trial name
- NCT06733155
- Testing
- Financial intervention, Lottery intervention, Health Messages
- Where
- Singapore
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Prostate Cancer, Active Surveillance for Prostate Cancer
Stockholm3 Test Validation in Men on Active Surveillance in Switzerland (CHAS3 Trial)
The CHAS3 trial studies whether the Stockholm3 blood test can reliably detect if prostate cancer becomes more aggressive in men who are being carefully monitored instead of treated right away (active surveillance).
- Trial name
- CHAS3 (NCT07478536)
- Testing
- Stockholm3
- Where
- Switzerland
- Volunteers
- 350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Lung Cancer, Brain Metastasases
Annual Brain MRI Surveillance for Detection of Brain Metastasis in Patients With Lung Cancer
This retrospective observational study will evaluate the effectiveness of periodic brain magnetic resonance imaging surveillance for detecting brain metastasis in patients with lung cancer.
- Conditions
- Lung Cancer, Brain Metastasases, MRI, Surveillance
- Trial name
- NCT07646041
- Volunteers
- 229,323 people
- Sponsor
- Samsung Medical Center
Giant Cell Tumor of Bone, TRACP-5b
TRACP-5b for Diagnosis and Follow-up of Giant Cell Tumor of Bone
This prospective observational study will evaluate whether the blood biomarker TRACP-5b can help diagnose and monitor patients with giant cell tumor of bone (GCTB).
- Conditions
- Giant Cell Tumor of Bone, TRACP-5b, Disease Surveillance and Monitoring, Tartrate-Resistant Acid Phosphatase 5b
- Trial name
- NCT07609277
- Testing
- Tartrate-Resistant Acid Phosphatase 5b
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Active Surveillance, Clear Cell Renal Cell Carcinoma
Belzutifan's Role in Active Surveillance Versus Treatment for Indolentmetastatic Clear Cell Renal Ccell Carcinoma (BRAVE-RCC)
To learn if belzutifan can help to control the disease in patients with metastatic RCC who are considered candidates for active surveillance and have not undergone previous systemic treatment.
- Trial name
- NCT07023432
- Testing
- Belzutifan, Active Surveillance
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- M.D. Anderson Cancer Center
Maternal and Perinatal Death Surveillance and Response (MPDSR) Implementation, Maternal Mortality
Accelerating Maternal and Newborn Survival: The AMANI Study
The goal of this cluster randomized controlled trial is to learn if a practice facilitation package (including both audit and feedback and enhanced mentorship) can increase the use of maternal and perinatal death surveillance and…
- Conditions
- Maternal and Perinatal Death Surveillance and Response (MPDSR) Implementation, Maternal Mortality, Neonatal Mortality, Perinatal Mortality
- Trial name
- AMANI (NCT07560839)
- Testing
- Audit and Feedback, Enhanced Mentorship
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Washington
Molecular Surveillance, Breast Cancer
Molecular Surveillance In Early Breast Cancer Using The Tumor-Informed ctDNA Assay Myriad Genetics Precise MRD Test; A Prospective Observational Multicenter Study (The MRD Molecular Surveillance Study)
To learn about changes in ctDNA during the diagnosis, treatment, and post-treatment surveillance of EBC.
- Conditions
- Molecular Surveillance, Breast Cancer, ctDNA, MRD
- Trial name
- NCT07475923
- Testing
- Blood draw for the laboratory assessment, Neoadjuvant treatment
- Sponsor
- M.D. Anderson Cancer Center
Suspicion of Bladder Cancer, NMIBC Surveillance
Bladder EpiCheck Product Development Study
This is a prospective, observational study to support the development of the Bladder EpiCheck kit by collecting urine samples from subjects suspected to have a bladder tumor or under NMIBC surveillance.
- Trial name
- NCT07514143
- Testing
- Bladder EpiCheck
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Nucleix Ltd.
Triple Negative Breast Cancer, Surveillance
Early Detection of Metastatic Recurrence Among Patients With Stage II or III Triple Negative Breast Cancer Using Liquid Biopsy and Imaging
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer, often with poor outcomes. Currently, follow-up for TNBC consists of physical exams and annual breast imaging, with additional scans only if symptoms…
- Conditions
- Triple Negative Breast Cancer, Surveillance, Recurrence, ctDNA
- Trial name
- EINSTEIN-TNBC (NCT07478705)
- Testing
- ctDNA-guided imaging surveillance, Standard
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer, Breast Cancer Recurrence
Optimal Mammography View Sequencing in Women With a History of Breast Cancer Undergoing Surveillance Mammography
This prospective, single-centre, parallel-group randomised controlled trial evaluates the optimal sequencing of mammography views in women with a history of breast cancer undergoing surveillance mammography.
- Conditions
- Breast Cancer, Breast Cancer Recurrence, Post Treatment Surveillance
- Trial name
- MammoView (NCT07443579)
- Testing
- Mammography View Sequencing
- Where
- Ireland
- Volunteers
- 400 people
- Sponsor
- Royal College of Surgeons, Ireland
Surveillance, Endoscopy
"Airway Complications in Pediatric Patients With Tracheostomies: To What Extent Can Symptoms Identified by Caregivers or Pediatricians Serve as Predictors for Airway Complications Confirmed Through Surveillance Endoscopy?"
Study Objective: This observational study aims to prospectively investigate to what extent tracheostomy-related complications in children are asymptomatic or associated with symptoms when detected through surveillance airway…
- Conditions
- Surveillance, Endoscopy, Tracheostomy Complication, Tracheostomy Complications
- Trial name
- NCT07121517
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Prostate Cancer, Active Surveillance for Prostate Cancer
Micro-Ultrasound for Detecting Clinically Significant Prostate Cancer in Active Surveillance
Active surveillance is a common approach for men with low-risk or favorable intermediate-risk prostate cancer, aimed at avoiding or delaying treatment while closely monitoring the disease.
- Conditions
- Prostate Cancer, Active Surveillance for Prostate Cancer, Imaging Techniques
- Trial name
- MUS-AS (NCT07386171)
- Testing
- Micro-Ultrasound (mUS)
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Immune Surveillance, Stem Cell Surveillance
Rapid Effects on Antioxidant Status, Immune Alertness, and Regenerative Activity
This clinical study aims at documenting rapid effects after consuming single doses of test product, when compared to consuming a placebo. A double-blind, placebo-controlled, cross-over study design will be used.
- Trial name
- NCT07142720
- Testing
- A low dose of seaweed extract, A high dose of seaweed extract
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Suicide, Surveillance
Southwest Hub for American Indian Youth Suicide Prevention Research
1. To use a SMART design to evaluate which of four sequences of New Hope (NH), Elders Resilience (ER) and Case Management (CM) have the greater effects on immediate and longer-term suicidal ideation (primary outcome) and…
- Conditions
- Suicide, Surveillance, Mental Health, Substance Use
- Trial name
- NCT03543865
- Testing
- New Hope (NH), Elders Resilience (ER), Case Management (CM)
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health