Clinical trials: Suspected Acute Coronary Syndrome
Non-ST-elevation Myocardial Infarction (NSTEMI)
Hs-cTnI Diagnosis of NSTE-ACS Patients in China
This study is to validate 1-hour and 3-hours diagnostic strategy using Architect high-sensitivity cardiac troponin I (hs-cTnI) in Chinese patients with suspected Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- HEADLINES (NCT03734796)
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome, Acute Myocardial Infarction
Switching From Cardiac Troponin I to T
Cardiac troponin is central to the diagnosis of myocardial infarction and high-sensitivity cardiac troponin (hs-cTn) assays are the preferred choice for the assessment of patients with suspected acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Acute Myocardial Ischemia, Myocardial Injury
- Trial name
- TWITCH-ED (NCT05748691)
- Testing
- Clinical implementation of hs-cTnT
- Where
- United Kingdom
- Volunteers
- 26,000 people
- Sponsor
- University of Edinburgh
High Grade Obstructive NSTE-ACS
Infrasensor for Early Detection of a High-grade Obstructive NSTE-ACS
The objective of this prospective, cross-sectional, multicenter pivotal trial study is to validate Infrasensor's clinical performance for the detection of high grade obstructive NSTE-ACS.
- Trial name
- NCT07464704
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- Remote Cardiac Enablement
Acute Coronary Syndrome (ACS)
Optimum Troponin Cutoffs for ACS in the ED
Blood tests may be able to quickly identify and exclude patients that are having a heart attack. Using these tests in the Emergency Department (ED) may lead to faster treatment, a reduced wait time, and quicker discharge for…
- Trial name
- ROMI-3 (NCT01994577)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Canadian Institutes of Health Research (CIHR)
Chest Pain, Myocardial Infarction
The Supplementary Role of Non-invasive Imaging to Routine Clinical Practice in Suspected Non-ST-elevation Myocardial Infarction
Approximately half of patients with acute chest pain, a very common reason for emergency department visits worldwide, have a cardiac cause.
- Conditions
- Chest Pain, Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- CARMENTA (NCT01559467)
- Testing
- Cardiovascular Magnetic Resonance Imaging, Computed Tomography Angiography
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome
Patients with a non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are currently transported and admitted to the nearest emergency department (ED) for risk stratification, diagnostic workup, and treatment.
- Trial name
- NCT06051110
- Testing
- Combined risk score, Usual care, point-of-care troponin
- Where
- Netherlands
- Volunteers
- 5,239 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Acute Coronary Syndrome, STEMI
Usefulness of High-frequency QRS Analysis in the Evaluation of Patients With Chest Pain
Accurate detection of a heart attack (an acute myocardial infarction) is one of the most pressing needs in medicine. Recordings of the electrocardiogram (ECG) (electrical activity of the heart) are one of the first tools used to…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI, Unstable Angina
- Trial name
- NCT01185899
- Where
- Israel
- Volunteers
- 324 people
- Sponsor
- Ori Galante
Acute Coronary Syndrome
TnThs Predicting Evolving Non-STEMI
BACKGROUND: We sought to determine the diagnostic value of the new TnThs assay for early detection of evolving non-STEMI in patients with acute coronary syndrome and a negative 4th generation cTnT result on admission.
- Trial name
- NCT00953251
- Where
- Germany
- Volunteers
- 115 people
- Sponsor
- Heidelberg University
NSTEMI - Non-ST Segment Elevation MI, ACS - Acute Coronary Syndrome
Early Cardiac Magnetic Resonance Imaging in Suspected Non-ST-Elevation Myocardial Infarction
Background and rationale: Evaluating patients with acute chest pain, elevated high-sensitive cardiac troponin (hs-cTn) levels and non-diagnostic electrocardiogram (ECG), i.e.
- Trial name
- CMR-OBSERVE (NCT04140019)
- Testing
- CMR
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Maastricht University Medical Center
Acute Chest Pain, NSTEMI - Non-ST Segment Elevation MI
Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department.
- Trial name
- PRESC1SE-MI (NCT05649384)
- Testing
- European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm, European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm
- Where
- 20 sites in United States, Australia and 9 more
- Volunteers
- 64,374 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS)
Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers
Oxygen treatment is widely used in acutely ill patients, both pre-hospital and in hospital. The indication for oxygen is sometimes unquestionable, such as in many hypoxic patients, but in other situations its use is more of a…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS), ST Elevation (STEMI) Myocardial Infarction, Ischemic Reperfusion Injury
- Trial name
- DETO2X-bio (NCT02290080)
- Testing
- Oxygen
- Where
- 2 sites in Sweden
- Volunteers
- 175 people
- Sponsor
- Karolinska Institutet
Acute Coronary Syndrome
TnThs for Identification Myocardial Infarction
OBJECTIVES/BACKGROUND: We sought to determine the early diagnostic value of the new high sensitive cardiac troponin T assay (TnThs) in suspected acute coronary syndrome (ACS) and to compare it with the 4th generation cTnT assay…
- Trial name
- NCT00950469
- Where
- Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Acute Myocardial Infarction
Effect of the Biomarker Copeptin in Managing Patients With Suspected Acute Coronary Syndrome (ACS)
Acute chest pain is commonly known to be the classic symptom of acute myocardial infarction. Of the many patients which visit the Emergency Department because of chest pain, less than half do actually suffer from an acute…
- Trial name
- BiC-8 (NCT01498731)
- Testing
- Discharge home
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 902 people
- Sponsor
- Charite University, Berlin, Germany
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Patients with a suspected myocardial infarction are subdivided into ST-elevation and non-ST-elevation myocardial infarctions (STEMI and NSTEMI, respectively) using ECG.
- Trial name
- KaPSICA-CMR (NCT06566625)
- Testing
- Cardiac MRI (CMR) examination
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Acute Coronary Syndrome
Study of 99mTc-glucarate to Detect Acute Coronary Syndrome in Chest Pain Patients.
The purpose of this clinical trial is to study the ability of a radioactive drug called "Technetium Glucarate" to detect whether the cause of chest pain in patients entering the emergency department with no obvious signs of heart…
- Trial name
- NCT00614354
- Testing
- 99mTc-glucarate solution
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- Molecular Targeting Technologies, Inc.
Chest Pain, Shortness of Breath
ProspEctive First Evaluation in Chest Pain Trial
The purpose of this study is to determine the best initial test in patients admitted to the hospital complaining of chest pain.
- Conditions
- Chest Pain, Shortness of Breath, Suspected Acute Coronary Syndrome
- Trial name
- PERFECT (NCT01604655)
- Testing
- Coronary CT Angiography, Stress Test
- Where
- United States
- Volunteers
- 411 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Myocardial Infarction (MI), Acute Coronary Syndromes (ACS)
Prehospital Point-of-Care Hs-Troponin I for Rule-Out of Acute Myocardial Infarction in Patients Without ST-Segment Elevation
People who call emergency medical services (EMS) with chest pain or other possible heart-related symptoms are often taken to hospital for further testing.
- Trial name
- Pre-POCT TnI (NCT07563998)
- Testing
- Prehospital high-sensitivity cardiac troponin I measurement
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Central Denmark Region
Acute Myocardial Infarction
Validation of a High-risk Versus Low-risk Referral Model in Suspected Acute Coronary Syndrome
In Emergency Departments patients admitted with chest pain may suffer from non-significant to lifethreatening conditions. The aim of the present study is to develop and validate a referral model in chest pain patients which…
- Trial name
- NCT01747421
- Where
- Denmark
- Volunteers
- 495 people
- Sponsor
- University of Southern Denmark
ACS, NSTEMI - Non-ST Segment Elevation MI
Prehospital Triage of Patients With Suspected Non-ST-segment Elevation Acute Coronary Syndrome: the TRIAGE-ACS Study
With the Emergency Medical Services (EMS), no prehospital risk stratification and triage is performed for patients suspected of having an Non-ST-segment elevation Acute Coronary Syndrome (NSTE-ACS).
- Conditions
- ACS, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT05243485
- Testing
- PreHEART
- Where
- Netherlands
- Volunteers
- 1,071 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Chest Pain
Modified HEART as Rule Out for Suspected ACS
Validation of modified HEART score as a rule-out criterion for MACE at 6 weeks: a 2 centre prospective observational cohort with a direct comparison to TIMI, GRACE and high sensitive troponin T at limits of detection Detailed…
- Trial name
- NCT03619733
- Testing
- no intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust