Clinical trials: Swallowing Disorders
Gastroesophageal Reflux Disease
Anthropometric Measures and Severity of Gastroesophageal Reflux Disease
evaluate the impact of different anthropometric measures on clinical and endoscopic severity of GERD and its relation to serum leptin.
- Trial name
- NCT01954667
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Esophagogastric Cancer
A Study of Tooth Erosion in People With Esophagogastric Cancer
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer…
- Trial name
- NCT05612048
- Testing
- Survey, Intra-oral camera, Optional Salvia sample
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Amyotrophic Lateral Sclerosis
Remote Speech and Swallowing Assessment in ALS
The investigators propose a longitudinal home study of ALS patients to measure the severity of speech and swallowing (bulbar) impairment via a smartphone-based, remote speech and swallow assessment (rSSA).
- Trial name
- NCT04889898
- Testing
- Digital recording of speech and swallow sounds using the Beiwe Digital Health App on a personal smartphone, Modified Barium Swallow Study (MBSS), Speech Intelligibility Test (SIT)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gender Dysphoria
Comparison of PKs of 17-Beta-Estradiol Via Sublingual Placement Versus Swallowing in Male-to-Female Transgender Patients
This crossover study will investigate the pharmacokinetics of oral versus sublingual administration of 17-beta-estradiol in the trans-female population.
- Trial name
- NCT05428215
- Testing
- 17beta Estradiol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Achalasia
Evaluation of a Novel Endoscopic Treatment for Achalasia
This study is to evaluate outcomes of a less invasive surgical procedure for the treatment of achalasia.
- Trial name
- POEM (NCT01770249)
- Testing
- Per-oral Endoscopic Esophagomyotomy (POEM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Dysphagia, Esophageal, Esophageal Cancer
Validation of Instruments Used for Assessment of Dysphagia in Patients With Esophageal Cancer
This study validates 3 well known dysphagia scores for dysphagia due to malignancies of the oesophagus and gastro-oesophageal junction and to the Swedish language.
- Trial name
- NCT03066167
- Testing
- Validation of different dysphagia scores
- Where
- Sweden
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Gastroesophageal Reflux Disease
Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease
Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI)…
- Trial name
- NCT01504971
- Testing
- symptom questionaire, pH monitoring, Tri-modal imaging endoscopy
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Deglutition Disorders, Neurological Disorder
Automatic Voice Analysis for Dysphagia Screening in Neurological Patients
The proposed study suggests using automatic voice analysis and machine learning algorithms to develop a dysphagia screening tool for neurological patients.
- Trial name
- VOICED (NCT06219200)
- Where
- 2 sites in Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Bronchiectasis
The Prevalence of Gastro-oesophageal Reflux in Chronic Lung Disease
Gastric reflux into the oesophagus may further lung damage in respiratory disease. The proportion of adults with chronic lung disease and gastric reflux is unknown.
- Trial name
- NCT00697177
- Where
- Australia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Barrett's Esophagus, Gastroesophageal Reflux
Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neoplasia
The primary purpose of this study is to test new methods to diagnose BE in time before it turns into advanced cancer. Once BE is diagnosed, the current standard of care is to monitor the disease so that complication such as…
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT02464930
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Oropharyngeal Dysphagia (OPD), Parkinson
Results of Combined Medical and Swallowing Behavioral Readjustment Therapy in Oropharyngeal Dysphagia Management Among Parkinson's Patients
The study aims to assess the efficacy of using swallowing behavioral readjustment technique in combination with medical treatment in management of oropharyngeal dysphagia among Parkinson's patients in order to improve the…
- Conditions
- Oropharyngeal Dysphagia (OPD), Parkinson, Swallowing Difficulties
- Trial name
- NCT07618637
- Testing
- combined pharmaceutical treatment and rehabilitation techniques, pharmaceutical treatment only
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tanta University
Colic, Infantile, Milk Allergy, Cow's
Validation Of A Parent Administered Symptom Score For Unsettled Infants (Every Baby is UnIQue)
It's common for infants to be unsettled, especially in the first few months of life. While this is often normal, persistent symptoms can be stressful for families.
- Conditions
- Colic, Infantile, Milk Allergy, Cow's, Gastro Oesophageal Reflux Disease, Atopic Dermatitis (Eczema)
- Trial name
- NCT07121062
- Testing
- Online parent administered questionnaire
- Where
- United Kingdom
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Stroke, Spinocerebellar Ataxia
Laryngeal Adaptation for Speech and Swallowing
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6.
- Conditions
- Stroke, Spinocerebellar Ataxia, Cerebral Stroke, Dysphagia
- Trial name
- NCT03770377
- Testing
- Intermittent Perturbation to Continuous Perturbation, Continuous Perturbation to Intermittent Perturbation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Gastroesophageal Reflux Disease, Barrett's Esophagus
Survey Study on Barrett's Esophagus Screening
The goal of this study is to optimize Barrett's Esophagus (BE) screening to reduce the incidence, morbidity, and mortality of Esophageal Adenocarcinoma (EAC).
- Conditions
- Gastroesophageal Reflux Disease, Barrett's Esophagus, Esophagus Adenocarcinoma
- Trial name
- SCREEN-BE (NCT04408105)
- Testing
- Primary Care Provider Survey, Gastroenterologist Survey, Patient Survey
- Where
- 7 sites in United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gastro Esophageal Reflux
Effect of Magnesium Alginate in Infants With Gastroesophageal Reflux.
Recurrent regurgitation stress the infants and their parents and often results in an inappropirate use of PPI prescription in infancy.
- Trial name
- NCT03881722
- Testing
- Mg alginate
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Oropharyngeal Dysphagia
Rehabilitation Manometry Study
Oropharyngeal dysphagia, or difficulty swallowing, is a devastating condition that affects physiological and psychosocial functioning in 1 in 25 adults.
- Trial name
- NCT04130867
- Testing
- pHRM, VFSS
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Critical Illness, Dysphagia
Detection of Neuromuscular Complications in Critically Ill Patients
Dysphagia and the intensive care unit-acquired weakness (ICU-AW) are common and outcome-relevant neuromuscular complications in critically ill patients, especially after prolonged mechanical ventilation, sepsis and multi-organ…
- Conditions
- Critical Illness, Dysphagia, Intensive Care Unit Acquired Weakness, Neuromuscular Diseases
- Trial name
- NMCiCIP (NCT04541602)
- Where
- Germany
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Gastroesophageal Reflux, Dyspepsia
Effects of Diet on Reflux and Dyspepsia
Reflux and dyspeptic symptoms are common affecting 10-20% of the population on a regular basis. Reflux symptoms such as heartburn and regurgitation are caused by the return of acid or non-acid gastric contents into the esophagus.
- Trial name
- NCT02425553
- Testing
- Diet
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Zurich