Clinical trials: Sympathectomy
Arterial Hypertension, Resistant Arterial Hypertension
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation
It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and…
- Trial name
- NCT03243045
- Testing
- Renal sympathetic denervation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Myocardial Infarction, Acute
COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction
This study evaluates the benefit of colchicine on induced denervation after myocardial infarction. Patients who have suffered a documented De Novo myocardial infarction and completed a revascularization procedure will receive…
- Trial name
- COLD-MI (NCT04420624)
- Testing
- Colchicine
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Montpellier
Uncontrolled Hypertension
Effects of Renal Sympathetic Denervation on the Cardiac and Renal Functions in Patients With Drug-resistant Hypertension Through MRI Evaluation
This is a prospective, single centre clinical investigation looking at short (6 months) and long term (24 months) changes in cardiac function and renal function in patients with drug-resistant hypertension post renal sympathetic…
- Trial name
- RDN (NCT02164435)
- Testing
- Renal Denervation (EnligHTN™) Renal artery ablation with the EnligHTN™ Renal Denervation System.
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- University of Adelaide
Uncontrolled Hypertension, Atrial Fibrillation
Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
The objective of the H-FIB trial is to determine the role of renal sympathetic denervation in the prevention of Atrial Fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- H-FIB (NCT01635998)
- Testing
- Boston Scientific Vessix Renal Denervation System
- Where
- 8 sites in United States, Czechia and 1 more
- Volunteers
- 50 people
- Sponsor
- Vivek Reddy
Hypertension, Atrial Fibrillation
Renal Sympathetic Denervation in Patients With Hypertension and Paroxysmal Atrial Fibrillation
The purpose of this study is to demonstrate whether renal sympathetic denervation is safe and effective in patients with hypertension and paroxysmal atrial fibrillation.
- Trial name
- RSDforPAF (NCT01814111)
- Testing
- renal sympathetic denervation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hyperhidrosis, Quality of Life
Objective Evaluation of Patients With Palmar Hyperhidrosis Submitted to Two Levels of Sympathectomy: T3 and T4.
Compare the results obtained with video-assisted sympathectomy performed in two distinct levels ganglionic (third versus fourth thoracic ganglion) for the treatment of palmar hyperhidrosis, through a blind randomized clinical…
- Trial name
- NCT01140659
- Testing
- Video-assisted sympathectomy
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Palmar Hyperhidrosis
Unilateral Sequential Sympathectomy for Palmar Hyperhidrosis
Comparison between unilateral sequential and bilateral simultaneous endoscopic thoracic sympathectomy for palmar hyperhidrosis on patients outcomes notably compensatory hyperhidrosis.
- Trial name
- ETS (NCT02321332)
- Testing
- bilateral simultaneous endoscopic thoracic symapthectomy, unilateral sequential endoscopic thoracic symapthectomy.
- Volunteers
- 400 people
- Sponsor
- Tmaer Youssef Mohamed
Parkinson
Evaluation of Myocardial Sympathetic Denervation in Parkinson's Disease Using [18F]FDOPA
The purpose of this study is to evaluate the added value of PET-CT with [18F]FDOPA tracer for Assessment of the Myocardial Sympathetic Denervation in patients with or suspected with Parkinson's disease.
- Trial name
- NCT02495649
- Testing
- [18F]-DOPA, PET-CT
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Resistant Hypertension
Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension（RSDARH）
As one of the most common chronic diseases,The adult prevalence of hypertension is approximately 26.4% at present and will rise to 29.2% by 2025.Renal sympathetic denervation from the intima of renal artery has emerged as a…
- Trial name
- NCT03758196
- Testing
- Radiofrequency ablation instruments
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Hyperhidrosis
A Study to Compare Oxybutynin to a Placebo in Women and the Effect on Plantar Hyperhidrosis
A study in which the experimental treatment procedure is compared to a standard (control) treatment, The use of oxybutynin in the late postoperative thoracic sympathectomy for women: 1.
- Trial name
- NCT01328015
- Testing
- Oxybutynin 5 mg pills
- Volunteers
- 32 people
- Sponsor
- Federal University of São Paulo
Ventricular Tachycardia
REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation
Despite significant advances in the management of ventricular arrhythmias through the use of ICD therapy, AADs, and catheter-based ablation strategies, considerable challenges remain.
- Trial name
- RESET-VT (NCT01858194)
- Testing
- Renal sympathetic denervation, VT ablation alone
- Where
- 2 sites in United States, Czechia
- Volunteers
- 21 people
- Sponsor
- Vivek Reddy
Hypertension, Chronic Kidney Disease
Renal Sympathetic Denervation in Moderate to Severe Chronic Kidney Disease
A pilot, single-center, prospective, interventional study. The objective is to demonstrate that catheter-based renal denervation using carbon dioxide renal angiography in patients with moderate to severe chronic kidney disease…
- Trial name
- NCT02863510
- Testing
- Renal Sympathetic Denervation
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Heart of England NHS Trust
Atrial Fibrillation
Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation
The purpose of the ULTRA-HFIB Pilot is to determine the role of adjunctive renal denervation (RDN) in the prevention of Atrial Fibrillation (AF) recurrence in patients scheduled for an AF ablation procedure.
- Trial name
- ULTRA-HFIB (NCT04182620)
- Testing
- renal denervation, Catheter ablation
- Where
- 13 sites in United States
- Volunteers
- 160 people
- Sponsor
- Vivek Reddy
Primary Palmar Hyperhydrosis
Bilateral Endoscopic Thoracic T3 Sympathectomy Versus T3 Radiofrequency Ablation for Primary Palmar Hyperhidrosis
Primary hyperhidrosis disease is characterized by much more sweating above the needs for thermoregulation, which is worsen by increased temperature and emotional factors it can be seen in the palms of the hands, soles of the…
- Trial name
- NCT05737914
- Testing
- Endoscopic thoracic T3 sympathectomy, ThoracicT3 radiofrequency ablation
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Hypertension, Hemodialysis
Sympathetic Mapping/ Ablation of Renal Nerves Trial - Hemodialysis
To evaluate the safety and efficacy of targeted renal sympathetic denervation using SyMapCath I™ in patients on hemodialysis with pharmacotherapy and uncontrolled hypertension for at least 6 months, then after standardized…
- Trial name
- SMART-HD (NCT04872114)
- Testing
- SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Cardiac Failure
Renal Denervation in Heart Failure With Preserved Ejection Fraction
The purpose of this study is to determine whether renal sympathetic denervation (RSD)(a treatment that lowers the activity of the sympathetic nervous system) is useful in the management of patients with heart failure with…
- Trial name
- RDT-PEF (NCT01840059)
- Testing
- Renal sympathetic denervation
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Resistant Hypertension
Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Trial From RENEWAL RDN Registry)
1. (RENEWAL-EXERCISE trial) The investigators hypothesize that the increased sympathetic nervous system activation that is associated with resistant hypertension is a major contributor in the pathogenesis of exercise diastolic…
- Trial name
- NCT01918111
- Testing
- Renal denervation, adenosine infusion treatment
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University
Hypertension, Resistant to Conventional Therapy
Rapid Renal Sympathetic Denervation for Resistant Hypertension
The Covidien OneShot™ ablation system use is to deliver low-level radio frequency (RF) energy through the wall of the renal artery to denervate the human kidney.
- Trial name
- RAPID (NCT01520506)
- Testing
- Covidien OneShot™ System
- Where
- 14 sites in Belgium, Germany and 4 more
- Volunteers
- 50 people
- Sponsor
- Medtronic Endovascular
Sudden Cardiac Death, Ventricular Tachycardia
Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias
The purpose of this research study is to examine the effect of cardiac sympathetic denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead to…
- Conditions
- Sudden Cardiac Death, Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy
- Trial name
- PREVENT VT (NCT01013714)
- Testing
- Cardiac Sympathetic Denervation (CSD), Routine Care
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Arterial Hypertension, Chronic Renal Insufficiency
Renal Protection Using Sympathetic Denervation in Patients With Chronic Kidney Disease
Kidney protection study (KPS 1) is a prospective randomized clinical study comparing the use of renal denervation (RDN) and optimal medical therapy in subjects with chronic kidney disease stage 3-4 and resistant arterial…
- Trial name
- KPS (NCT02002585)
- Testing
- Renal denervation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic