Clinical trials: Sympathetic Activity
Traumatic Brain Injury, Dysautonomia
Controlling Hyperadrenergic Activity in Neurologic Injury
Traumatic brain injury (TBI) is frequently associated with a hyperadrenergic state accompanied by elevated levels of plasma catecholamines.
- Trial name
- CHAIN (NCT01343329)
- Testing
- Esmolol, Propranolol
- Where
- United States
- Sponsor
- Johns Hopkins University
SKNA According to Different Anesthetics
Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics
Skin sympathetic nerve activity (SKNA) has recently been discovered from the electrocardiogram obtained from healthy volunteers.
- Trial name
- NCT03763305
- Testing
- Propofol continuous infusion, Remifentanil, Sevoflurane
- Sponsor
- Seoul National University Hospital
Chronic Insomnia
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia
This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia.
- Trial name
- NCT03768713
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Montana State University
Takotsubo Cardiomyopathy
Sympathetic and Vascular Function in Takotsubo Syndrome
The primary objective of this prospective, observational study is to compare muscle sympathetic nerve activity at rest and during stress between female patients with Takotsubo syndrome and healthy, matched volunteers.
- Trial name
- SAFT (NCT05768542)
- Testing
- Metoprolol Injection, Saline
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Nervous System
Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique
Obesity is the consequence of an imbalance between energy intake and energy expenditure. Recent studies have suggested that the sympathetic nervous system (SNS) may be an important determinant of the rate of energy expenditure in…
- Trial name
- NCT00341770
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Tobacco; Use, Harmful
The Influence of Electronic and Traditional Cigarettes Smoking on Hemodynamic Parameters
It is intended to examine 50 healthy volunteers aged 18 - 60 years. 12-hour abstinence from tobacco smoke, alcohol or coffee before the experiment will be required.
- Trial name
- EPAPHemo (NCT03037775)
- Testing
- Baseline, e-cigarette without nicotine, e-cigarette with nicotine
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Heart Failure
Inspiratory Muscle Training Effectiveness in Sympathetic Activity and Functional Capacity in Patients With Heart Failure
Heart failure (HF) is configured major problem for public health in the country. Affected individuals may experience fatigue, dyspnea, respiratory muscle weakness, overstimulation of the sympathetic myocardial activity, among…
- Trial name
- NCT02600000
- Testing
- Myocardial scintigraphy, Cardiopulmonary test, AVD-Glittre Test
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Neck Pain
The Effects of Spinal Mobilizations on Symptoms, Neck 3D Movement, Neck Muscle Electromyography and Sympathetic Nervous System Activity in People With Neck Pain
This study investigates the effects of spinal mobilizations on symptoms, 3D movement of the neck, neck muscle electromyography and sympathetic nervous system activity in people with neck pain.
- Trial name
- NCT02826590
- Testing
- Neck passive mobilizations, Manual contact
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- King's College London
Coronary Heart Disease
Effect of Nicorandil on Cardiac Sympathetic Nerve for the Patients of Acute ST Segment Elevation Myocardial Infarction
The investigators evaluate the effects of intracoronary and intravenous administration of nicorandil on cardiac sympathetic nerve activity and distribution in patients with acute myocardial infarction undergoing primary…
- Trial name
- NCT04826497
- Testing
- nicorandil
- Volunteers
- 80 people
- Sponsor
- Xuzhou Central Hospital
Caffeine, Control
Caffeinated Chewing Gum & Wrestling Performance
The purpose of this study was to investigate the effect of caffeinated chewing gum on sympathetic nerve activity on wrestling simulation match.
- Trial name
- NCT06758336
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Cardiovascular Morbidity
Experimental Exposure to Air Pollutants and Sympathetic Nerve Activity in Human Subjects
The primary hypothesis of the study is that in healthy elderly subjects experimental exposure to air pollutants increases sympathetic nervous system activity compared with sham (clean air) exposure.
- Trial name
- Particles (NCT01914783)
- Testing
- ultrafine particles, ultrafine particles and ozone, clean air
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Restless Legs Syndrome, Neuropathic Pain
Spinal Cord Stimulation for Restless Legs Syndrome
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS).
- Trial name
- NCT03539081
- Testing
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marshall Holland
Heart Failure
Using Clonidine to Improve Leg Weakness in People With Heart Failure
People with heart failure often have weakness in their leg muscles. This study will determine whether the leg weakness is due to very high adrenaline levels and whether the medication clonidine can improve leg weakness.
- Trial name
- NCT00858845
- Testing
- Clonidine Patch
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Menopause, Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
- Conditions
- Menopause, Hot Flashes, Blood Pressure Regulation
- Trial name
- NCT06743269
- Testing
- High-Resistance Inspiratory Muscle Strength Training, Low-Resistance Inspiratory Muscle Strength Training, POWERbreathe K3 device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypercapnia
End Tidal CO2 and Masks: Is There a Correlation?
In light of the ongoing COVID-19 pandemic, wearing a mask has become a universal standard as an attempt to reduce the spread of COVID-19. As of 2020, more than half of all U.S.
- Trial name
- NCT06437301
- Testing
- Baseline measure of ETCO2 without mask, Baseline ETCO2 with mask, ETCO2 after 200 meter walk with mask
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Chronic Heart Failure
Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients
The purpose of this study is to verify the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure.
- Trial name
- NCT02219451
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- University of Sao Paulo General Hospital
Type 2 Diabetes
ATP Release and Sympathetic Nerve Activity in Patients With Type II Diabetes
Type II diabetes (T2D) is characterized by endothelial dysfunction, resulting in a poor tissue perfusion and function as well as an increased risk of cardiovascular events.
- Trial name
- NCT02001766
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Anders Rasmussen Rinnov
End-stage Renal Disease (ESRD), Kidney Disease
Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Hypothesis: Patients starting peritoneal dialysis with a glucose-based regimen have high sympathetic activity in response to an increase in leptin and insulin.
- Trial name
- SAPD (NCT01228279)
- Testing
- DIANEAL, EXTRANEAL
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension
Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation
Study design: Investigator initiated, single center The study is aimed 1) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1) to verify the…
- Trial name
- RND (NCT05421767)
- Testing
- nerve stimulation guided renal denervation procedure
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Binge Drinking
Alcohol and Neural Cardiovascular Control in Binge Drinkers
This study evaluates the impact of evening alcohol consumption on sympathetic activity and baroreflex function in binge drinkers.
- Trial name
- NCT03567434
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Baylor University