Clinical trials: Sympathetic Disorder
Autonomic Peripheral Nervous System Diseases
Clinical Translation of 18F-Labeled Hydroxyphenethylguanidines
The purpose of this study is to perform first-in-human PET imaging studies of two new cardiac sympathetic nerve imaging agents, 4-[18F]fluoro-meta-hydroxyphenethylguanidine ([18F]4F-MHPG) and…
- Trial name
- NCT02385877
- Testing
- [18F]4F-MHPG, [18F]3F-PHPG
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hypertension
Vascular Responses to Sympathetic Activation and Altered Shear Rate: The Impact of Hypertension and Sodium Intake
The aim of this study is to determine if alterations in sodium intake alter peripheral vascular function and exercise tolerance in young individuals.
- Trial name
- NCT03558022
- Testing
- Salt Pills
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Rosacea
Role of the Sympathetic Nervous System in Rosacea
Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause.
- Trial name
- NCT03989492
- Testing
- systemic and local stressors
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kristen Metzler-Wilson
Cesarean Section Complications, Spinal Anesthesia
Ultrasound Guided Fluid Loading Before Spinal Anesthesia
Perioperative hypotension is a common complication of spinal anesthesia during cesarean sections. The aim of this study was to evaluate the effectiveness of echoguided correction of hypovolemia through crystalloid preloading on…
- Conditions
- Cesarean Section Complications, Spinal Anesthesia, Hypotension, Hypovolemia
- Trial name
- EHCOPRESPA (NCT07108881)
- Testing
- C, T
- Where
- Tunisia
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Parkinson Disease, Neuroendocrine Tumors
124I-MIBG Tracer Evaluation of Myocardial Sympathetic Denervation and Assessment of Neuroendocrine Tumors.
The Feasibility of Novel 124I-MIBG Tracer in Evaluation of Myocardial Sympathetic Denervation and Assessment of Neuroendocrine tumors. Comparison with 123I-MIBG.
- Trial name
- NCT01931488
- Testing
- MIBG label with I123 or I124, SPECT imaging
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Alcohol Use Disorder
Study of Mechanisms of Emotion Regulation in Alcohol-abstinent Patients
Background: Difficulties in assigning and identifying emotional states, or to regulate the emotional costs are recognized as one of the major factors of relapse.
- Trial name
- REAL (NCT02881983)
- Testing
- the presentation of pictures (static stimuli) or videos (dynamic stimuli)
- Where
- 2 sites in France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
POTS - Postural Orthostatic Tachycardia Syndrome
RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome
RESET-POTS is a pilot study for adults with postural orthostatic tachycardia syndrome (POTS), a condition that can cause a rapid increase in heart rate, dizziness, weakness, fatigue and other symptoms when standing.
- Trial name
- RESET-POTS (NCT07837804)
- Testing
- Bilateral Sequential Stellate Ganglion Block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Hypertension, Obesity
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress.
- Trial name
- OB-HTN (NCT04838678)
- Testing
- Neuropeptide Y
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injury
Cardiovascular, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
Increased life expectancy in individuals with spinal cord injury (SCI) present clinicians with the challenge of managing the secondary complications of SCI with the chronic diseases common in an aging population.
- Trial name
- NCT02122991
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Autonomic Nervous System Disease
Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms
This study aimed to compare the acute autonomic and hemodynamic effects of two arterial baroreflex resonance interventions-Resonance Breathing (RB) and Postural Resonance (PR)-in healthy young adults.
- Trial name
- Autonomic (NCT07536997)
- Testing
- Resonance Breathing, Postural Resonance
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Healthy, Autonomic Nervous System Diseases
Prevalence of Chapman Reflex Points in Medical Students and Their Association With Visceral Symptoms
Chapman Reflex Points (CRPs) are small palpable nodules found within connective tissue that have traditionally been associated with dysfunction of internal organs and the autonomic nervous system.
- Conditions
- Healthy, Autonomic Nervous System Diseases, Lymphatic Diseases, Somatic Dysfunction
- Trial name
- NCT07691112
- Testing
- Chapman Reflex Point Examination
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Obstructive Sleep Apnea
Effects of Exercise Training on Cognitive Performance and Sympathetic Activity in Obstructive Sleep Apnea
Abstract Obstructive sleep apnea syndrome (OSA) is characterized by complete or partial collapse of a narrowed pharynx and it's associated with reduction in cerebral blood flow, cardiovascular disease, and neuropsychological…
- Trial name
- NCT02289625
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obesity, Ageing
Brown Adipose Tissue Activity and Age
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between…
- Trial name
- NCT02130154
- Testing
- 18-FDG PET CT scan and 123I-MIBG SPECT scan
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sleep Deprivation
Cardiovascular Effects of Partial Sleep Deprivation
Background: Sleep curtailment is common and is associated with increased mortality due to cardiovascular causes. However, the mechanisms are not completely understood.We hypothesized that partial sleep deprivation caused however…
- Trial name
- NCT00669513
- Testing
- Partial sleep deprivation
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Heart Failure
Targeting Sympathetic Overactivity in Heart Failure Patients With Statins
Heart failure (HF) is a leading cause of morbidity and mortality in the United States with the incidence and prevalence of the disease on a continual rise.
- Trial name
- NCT01097785
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
CRPS Type I of the Upper Extremity, Neuropathy of the Median Nerve
Two Measures of Tactile Acuity in CRPS Type I Patients
This study aims to investigate whether two different measures of tactile acuity lead to comparable results in patients diagnosed with CRPS Type I of the upper extremity.
- Conditions
- CRPS Type I of the Upper Extremity, Neuropathy of the Median Nerve, Healthy Controls
- Trial name
- NCT01888783
- Testing
- Tactile acuity measured by 2PD and the GOT
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Vasodilation, Vasoconstriction
Vascular Function Improvements After Chronic Passive Stretching
Acutely, during different bouts of passive stretching (PS), blood flow (Q ̇) and shear rate ( ) in the feeding artery of the stretched muscles increases during the first two elongations and then it reduces during the following…
- Conditions
- Vasodilation, Vasoconstriction, Stretch, Sympathetic; Imbalance
- Trial name
- NCT04271241
- Testing
- Passive stretching (PS) training
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Milan
Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin
Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)
The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the…
- Conditions
- Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin, Healthy Subjects
- Trial name
- NCT01623141
- Testing
- Pressure Pain measurement
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Heart Failure, Congestive
Meta-Iodobenzylguanidine Scintigraphy Imaging in Patients With Heart Failure and Control Subjects Without Cardiovascular Disease
The study is designed to study the utility of 123I-mIBG as a diagnostic imaging agent to predict cardiac outcomes in subjects with heart failure and in comparison to subjects without cardiovascular disease.
- Trial name
- NCT00126425
- Testing
- 123I-mIBG (meta-iodobenzylguanidine)
- Where
- United States
- Volunteers
- 587 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Parkinson
Evaluation of Myocardial Sympathetic Denervation in Parkinson's Disease Using [18F]FDOPA
The purpose of this study is to evaluate the added value of PET-CT with [18F]FDOPA tracer for Assessment of the Myocardial Sympathetic Denervation in patients with or suspected with Parkinson's disease.
- Trial name
- NCT02495649
- Testing
- [18F]-DOPA, PET-CT
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center