Clinical trials: Symptom
Sickle Cell Disease, Sickle Cell Crisis
Optimal Timing of Ketamine Initiation for SCD Pain
The goal of this clinical trial is to learn if the use of early ketamine decreases the chance of admission to the hospital in patients with sickle cell disease presenting with pain.
- Trial name
- NCT07450430
- Testing
- Ketamine hydrochloride injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Boston Children's Hospital
Hepatitis C
An Observational Study of Maviret (Glecaprevir/Pibrentasvir) for Korean Chronic Hepatitis C Genotypes 1 to 6 Patients According to the Standard for Re-examination of New Drugs
Post-marketing surveillance study to evaluate the real world safety and effectiveness of Maviret (Glecaprevir/Pibrentasvir) administered under a normal, routine treatment practice by Korean patients with Chronic Hepatitis C…
- Trial name
- Maviret PMS (NCT03740230)
- Where
- 61 sites in South Korea
- Volunteers
- 3,134 people
- Sponsor
- AbbVie
Intractable Pain, Intensive Care
Ketamine and Refractory Painful Care in a Palliative Unit
Pain is one of the major symptoms in palliative care units and often is very difficult to treat, being considered as a refractory pain.
- Conditions
- Intractable Pain, Intensive Care, Pressure Ulcer, Pain Management
- Trial name
- KETAREF (NCT02587130)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Lille Catholic University
Treatment of Acute Zika Virus Infection
Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans
Zika virus (ZIKV) infection is a new emerging arbovirus disease, caused by the same vector that transmits Dengue virus, Aedes aegypti.
- Trial name
- NCT03443830
- Testing
- Tyzivumab
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tychan Pte Ltd.
Fraility, COPD (Chronic Obstructive Pulmonary Disease)
Respiratory Exercises in Frail Elderly COPD Patients
Purpose: This study evaluated the impact of a structured intervention on frailty, lung function, physical capacity, and dyspnea in elderly COPD patients.
- Conditions
- Fraility, COPD (Chronic Obstructive Pulmonary Disease), Older Adults (65 Years and Older)
- Trial name
- NCT07472530
- Testing
- breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Iron Supplementation and Gastrointestinal Health, Iron Deficiency
Modulation of hepcidIN With Co-supplementation of Iron and FORMulated Curcumin in Recreational Athletes
Iron deficiency and iron deficiency anaemia are common among endurance athletes partly due to a repeated post-exercise elevation of hepcidin, a hormone limiting iron entry through the intestine.
- Trial name
- IN-FORM (NCT07078630)
- Testing
- HydroCurc®, Ferrous sulphate 200mg oral tablet providing 65 mg of elemental iron
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Shock, Cardiogenic
Abciximab in Patients Undergoing Percutaneous Coronary Intervention for Cardiogenic Shock
Outcome of patients with myocardial infarction complicated with cardiogenic shock is very poor. Although early mechanical revascularization has been demonstrated superior to conservative medical treatment, mortality range remains…
- Trial name
- NCT00420030
- Testing
- Abciximab
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer
RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00726830
- Testing
- methadone hydrochloride, morphine sulfate, oxycodone hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Leukemia, Lymphoma
Total-Body Irradiation and Chemotherapy Followed By Donor Bone Marrow Transplant in Treating Young Patients With Hematologic Cancer
RATIONALE: Giving chemotherapy and total body irradiation before a donor bone marrow transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00028730
- Testing
- anti-thymocyte globulin, filgrastim, cyclophosphamide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Type 2 Diabetes Mellitus (T2DM), Obesity and Overweight
CK-0045 Proof-of-concept Study in Participants With Overweight / Obesity and Type 2 Diabetes
The goal of this clinical trial is to learn if treatment with CK-0045 improves blood sugar control after a meal in participants with type 2 diabetes mellitus (T2DM) and overweight/obesity.
- Trial name
- NCT06611930
- Testing
- CK-0045
- Where
- 2 sites in Germany
- Volunteers
- 90 people
- Sponsor
- Cytoki Pharma
Dizziness, Balance; Distorted
Effects of Gaze Stabilization Exercises on Dizziness, Balance and Quality of Life in Cervical Spondylosis Patients
To determine the effects of gaze stabilization exercises on dizziness, balance and quality of life in patients with cervical spondylosis.
- Conditions
- Dizziness, Balance; Distorted, Cervical Spondylosis
- Trial name
- NCT05707130
- Testing
- gaze stabilization exercises, neck isometrics
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Cellulite, Edematous Fibrosclerotic Panniculopathy (EFP)
Impact of CCH Treatment of Buttock and Thigh Cellulite in Adult Women
This is a single center, open-label, Phase 2a study to assess the photonumeric scale, morphological, and histopathological changes associated with Collagenase Clostridium Histolyticum (CCH) in adult women with moderate or severe…
- Trial name
- NCT04209530
- Testing
- EN3835
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Sepsis
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Dose Exploration Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Characteristics of STC314 Injection Administered Intravenously in Sepsis Patients
One study evaluated the efficacy and safety of intravenous STC314 injection in patients with sepsis Sex and pharmacokinetic profiles of a multicenter, randomized, double-blind, placebo-controlled II Phase I dose exploration…
- Trial name
- Sepsis (NCT06548854)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Grand Medical Pty Ltd.
Obesity, Overweight
The Effect of Mashed Potato Composition on Food Intake, Satiety and Blood Glucose
Potato is one of the world's most popular foods and is widely accepted as a staple food. The objective of this study is to determine the effect of consuming instant mashed potatoes with and without fat on glycemic response…
- Conditions
- Obesity, Overweight, Diabetes, Metabolic Syndrome
- Trial name
- NCT02009254
- Testing
- Dietary treatment
- Sponsor
- University of Toronto
Healthy
Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural
Hypothesis: Neutralization of acid production induced by the Western diet with oral administration of potassium citrate increases bone mineral density and bone mass as well as skeletal muscle mass and strength in elderly people…
- Trial name
- NCT00509405
- Testing
- potassium citrate
- Where
- Switzerland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baselland Bruderholz
Recent Acute Myocardial Infarction
Impact of the Obstructive Sleep Apnea Syndrome (OSAS) on the Ventricular Remodeling After Acute Myocardial Infarction
Coronary artery disease is a common and serious disease, the leading cause of death worldwide. Obstructive sleep apnea syndrome (OSAS) is common and often under-diagnosed in coronary artery disease where it could be involved in…
- Trial name
- SAS-IDM (NCT02439294)
- Testing
- Without Obstructive Sleep Apnea (syndrome), Mild or moderate Obstructive Sleep Apnea (syndrome), Severe Obstructive Sleep Apnea (syndrome)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Montpellier
Intra Abdominal Infections
Soluble Immune Checkpoints in Intra-Abdominal Infections
Intraabdominal infections is a life-threatening syndrome with a high incidence and a significant economic burden. The early-stage cytokine storm and the late-stage immunosuppression contribute to the mortality of sepsis.
- Trial name
- NCT07689266
- Testing
- Soluble Immune checkpoint levels
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Prediabetic State, Body Weight
Development of PI-ML Algorithm for Prediction of the Real-time Risk for Developing Pre-diabetes
In this prospective, non-randomized, monocentric study, data will be collected from otherwise healthy individuals with overweight/obese grade I to increase data availability in the pre-diabetes field (impaired glucose…
- Conditions
- Prediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
- Trial name
- PRAESIIDIUM (NCT06195566)
- Where
- Latvia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Jelizaveta Sokolovska
Peptic Ulcer Hemorrhage
China Survey of Peptic Ulcer Bleeding
This will be a multicenter prospective observational study carried out in China. The investigators will collect data in a pre-specified Case Report Form.
- Trial name
- PUB (NCT01241266)
- Where
- 31 sites in China
- Volunteers
- 1,044 people
- Sponsor
- AstraZeneca
Total Intravenous Anesthesia
The Effect of Mild Hypercapnia During Anesthetic Emergence on Recovery Time From TIVA
We hypothesized that patients with mild hypercapnia during anesthetic emergence after TIVA had a shorter recovery time than patients with normal blood carbonate levels.
- Trial name
- NCT05401266
- Testing
- mild hypercapnia
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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