Clinical trials: Symptom Management
Migraine, Depression
Brief Behavioral Intervention for Comorbid Migraine and Depression
The purpose of this research study is to examine whether a one-day group workshop, integrating principles from Acceptance and Commitment Therapy with Migraine Education, will result in improvements in depressive symptoms and…
- Trial name
- ACT-IM (NCT01775852)
- Testing
- ACT-IM
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Lilian N. Dindo
Obesity
Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity
Researchers are doing this study to compare the effects of drugs approved for long-term weight loss combined with an employer-based weight management program with the effects of the weight management program without drugs for…
- Trial name
- NCT03799198
- Testing
- Weight Management Program (WMP), Medication for chronic weight management (Rx)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Novo Nordisk A/S
Chronic Pain, Brain Injuries, Traumatic
Telehealth Pain Self-Management for Employed Adults
The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed.
- Conditions
- Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- E-TIPS (NCT04248725)
- Testing
- E-TIPS
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Washington
Obesity, Overweight
MOVE OUT: A Partnership With Veterans Groups to Enhance Weight Management in the Veterans Health Administration (VHA)
Obesity has been linked to several serious medical conditions, including high blood pressure, diabetes, and poor cholesterol levels.
- Conditions
- Obesity, Overweight, Hypertension, Diabetes Mellitus
- Trial name
- NCT01339390
- Testing
- MOVE OUT, MOVE!
- Where
- United States
- Volunteers
- 3,169 people
- Sponsor
- VA Office of Research and Development
Pain
Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair
The purpose of this study is to learn how well Liposomal Bupivacaine (Exparel™) controls post-operative pain in patients undergoing both open and laparoscopic (minimally invasive) abdominal hernia repair surgery.
- Trial name
- NCT02128646
- Testing
- EXPAREL, Ketorolac, laparoscopic abdominal hernia repair
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Kansas Medical Center
Suicide
Patient and Provider Outcomes of E-Learning Training in Collaborative Assessment and Management of Suicidality
Suicide prevention among military Veterans has become a national priority; yet, there is a gap in suicide-specific intervention training for mental health students and professionals.
- Trial name
- CAMS (NCT00905827)
- Testing
- CAMS
- Where
- 5 sites in United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Congestive Heart Failure, Metastatic Cancer
Advance Care Planning in the Emergency Department
This is a two-armed, parallel-design, pre-/post-intervention assessment study. The investigators will conduct a randomized controlled trial for ED GOAL on a cohort of 120 older adults with serious illness to collect…
- Conditions
- Congestive Heart Failure, Metastatic Cancer, Chronic Kidney Disease Requiring Chronic Dialysis, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05209880
- Testing
- ED GOAL
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Brigham and Women's Hospital
Stress, Psychological, Loneliness
Ecological Momentary Assessment and Text Message Intervention for Stress Management
Feasibility and acceptability of an Ecological Momentary Assessment (EMA) compared with an EMA plus automated text message intervention for stress management
- Conditions
- Stress, Psychological, Loneliness, Covid19, Stress
- Trial name
- NCT04907942
- Testing
- EMA + EMA and FACE Stress, EMA Alone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Click Therapeutics, Inc.
Type 2 Diabetes Mellitus, Obesity
Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
There is substantial clinical evidence regarding the safety and efficacy of currently practiced bariatric surgical techniques to improve metabolic control and/or resolve type 2 diabetes (T2DM) in clinically severe obese patients…
- Trial name
- SLIMM-T2D (NCT01073020)
- Testing
- Allergan Adjustable Gastric Band Surgery, Intensive Medical Diabetes & Weight Management (Why WAIT) - Band Group, Roux-en-Y Gastric Bypass (RYGB) Surgery
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Joslin Diabetes Center
Peripheral Artery Disease (PAD)
Walking Effect of Long Term Ticagrelor in Subjects With PAD Who Have Undergone EVR
To compare the effect of ticagrelor versus aspirin on the change in peak walking time, evaluated on the graded treadmill test, from one to 26 weeks post-revascularization in patients with peripheral artery disease who have…
- Trial name
- TI-PAD EVR (NCT02227368)
- Testing
- Ticagrelor, Comparator
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Pain, Quality of Life
Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy
Purpose: To compare the pain level and quality of life of the two sedation regimens consisting of diazepam in combination with meperidine or fentanyl.
- Trial name
- NCT02684942
- Testing
- Meperidine, Fentanyl
- Volunteers
- 40 people
- Sponsor
- Chulabhorn Cancer Center
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Pulmonary Disease, Chronic Obstructive
A Study to Look at Day to Day Changes in Lung Function in COPD Subjects Taking Albuterol/Salbutamol and Ipratropium
The objective of this study is to assess the daily variation in bronchodilator response to an inhaled short acting beta2-agonist (albuterol/salbutamol) and an inhaled short acting anticholinergic (ipratropium) individually and…
- Trial name
- NCT01691482
- Testing
- Albuterol/salbutamol, Ipratropium
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 56 people
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes, Obesity
Diabetes Data-Assisted Remission Trial (DDART)
The study team will study the efficacy of a high intensity medical weight loss intervention paired with a digital platform to create weight loss and induce remission of type 2 diabetes mellitus (T2DM) compared to a diabetes…
- Trial name
- NCT04663061
- Testing
- Medical weight loss, Diabetes education, Continuous glucose monitoring
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, PreDiabetes
Reducing Cardiometabolic Risk and Promoting Functional Health in Older Adults With Obesity and Prediabetes
Obesity and pre-diabetes threatens the overall health and functional independence of older adults but lifestyle weight management for diabetes prevention, soon to be reimbursed by Medicare, can reduce this burden.
- Conditions
- Obesity, PreDiabetes, Aging
- Trial name
- Sustain-DPP (NCT03500640)
- Testing
- DPP Intensive: 30-minute calls, DPP Support: 15-minute calls
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Asthma, Obesity
Trial of Roflumilast in Asthma Management (TRIM)
There are currently no treatments to specifically target asthma in obese adults. This pilot study is being conducted to investigate how effective roflumilast is in treating asthma in participants that have a higher BMI.
- Trial name
- TRIM (NCT03532490)
- Testing
- Roflumilast 500 Mcg Oral Tablet
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Asthma, Obesity
Asthma and Obesity: Pilot Study
Develop and pilot test four theory-based educational modules that integrate counseling for asthma and obesity to promote greater physical activity among people with asthma.
- Trial name
- NCT04113746
- Testing
- Better asthma self-management and incorporation of physical activity, Asthma Education
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Pain
Evaluation of a Peer Coach-Led Intervention to Improve Pain Symptoms
To maximize implementation potential of pain self-management in the VA, alternative delivery methods are needed to provide Veterans with education and support needed to self-manage their pain, without requiring additional…
- Trial name
- ECLIPSE (NCT02380690)
- Testing
- Peer Coach Assignment
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- VA Office of Research and Development
Urinary Stones, Urinary Tract Stones
Evaluation of Ureteral Stents in the Management of Stone Disease
A thin tube, called a ureteral stent, is inserted into the ureter and is commonly used as treatment of urinary stone disease. Stents are designed to help provide drainage of the kidney in the setting of an obstructing stone, or…
- Trial name
- NCT02211313
- Testing
- Randomization to size 6 French soft vs. size 6 French hydrophobic ureteral stent.
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington University School of Medicine
Anti-Psychotic, Management of Manifestations of Psychotic Disorders
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Cycle Pharmaceuticals Ltd. (Cycle) is developing an oral tablet formulation of Chlorpromazine Hydrochloride and intends to conduct bioequivalence trials to demonstrate its similarity to the RLD.
- Conditions
- Anti-Psychotic, Management of Manifestations of Psychotic Disorders, Treatment of Schizophrenia, Control Nausea and Vomiting
- Trial name
- NCT02943213
- Testing
- Chlorpromazine Hydrochloride
- Where
- South Africa
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cycle Pharmaceuticals Ltd.
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