Clinical trials: Symptomatic Carotid Stenosis, open to volunteers
Patients With Aterosclerotic Carotid Stenosis, Symptomatic Patients (Stenosis > 50%)
Carotid Revascularization With MicroNet Covered Stent Comparing Early Neurological Outcomes With Distal Versus Proximal EPS
The SIBERIA study demonstrated a clear advantage of CGuard stent implantation over the existing classical stent when using a distal anti-embolic device.
- Conditions
- Patients With Aterosclerotic Carotid Stenosis, Symptomatic Patients (Stenosis > 50%), Asymptomatic Patients (Stenosis ≥80%)
- Trial name
- SIBERIA-2 (NCT05257161)
- Testing
- Emboshield NAV6™, Mo.Ma™
- Where
- Russia
- Volunteers
- 366 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Carotid Stenosis
Alirocumab for Stabilisation of Symptomatic Vulnerable Carotid Plaque
CAROTID-STABILISE is a phase III, multicentre, randomised, double-blind, placebo-controlled trial evaluating whether alirocumab 150 mg subcutaneously every 2 weeks, added to high-intensity statin therapy, produces greater…
- Trial name
- CAROTID-STABIL (NCT07586540)
- Testing
- Alirocumab, Atorvastatin
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 280 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Ischemic Stroke, Transient Ischemic Attack
Comparison Between Non-contrast Magnetic Resonance Angiography and Carotid Doppler in Cerebrovascular Stroke
This prospective observational study aims to compare the diagnostic performance of non-contrast magnetic resonance angiography (NC-MRA) and carotid Doppler ultrasonography in the evaluation of carotid artery disease among…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Carotid Artery Stenosis (Symptomatic and Asymptomatic)
- Trial name
- NCT07756775
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
CAROTID STENOSIS
Plaque and Brain Inflammation in Symptomatic Carotid Stenosis: Role of the Ficolin-2
Carotid artery stenosis is observed in about 3% of ≥ 60 years subjects and accounts for around 10-20% of all ischemic strokes. Beyond the degree of stenosis, plaque composition affects the risk of ischemic stroke.
- Trial name
- STATEMENT (NCT05850247)
- Testing
- [18F]DPA-714 PET/MRI
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
CEST-PROTECT: Proximal Flow Control With a Balloon Guide Catheter Plus Distal Embolic Protection: a Randomised, Open-label Trial Evaluating Cerebral Protection Techniques
This randomized controlled trial aims to evaluate whether a proximal-distal dual cerebral protection strategy can reduce the occurrence of new cerebral ischemic lesions compared with a single cerebral protection strategy in…
- Trial name
- CEST-PROTECT (NCT07841132)
- Testing
- BGC proximal flow control plus distal filter embolic protection device during carotid artery stenting, Single distal filter embolic protection device during carotid artery stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Artery Disease, Symptomatic Carotid Artery Stenosis
High Coverage CARotid Stenting vs. Medical Management Alone to Prevent EmboliSm From symptomaTic Non-stenotic cARotid Disease (SyNC)
Goal is to analyse the clinical safety and efficacy of the CARESTO® heal Stent within standard clinical routine for the treatment of patients with symptomatic non-stenotic carotid disease (SyNC) and with high-risk plaque features…
- Conditions
- Carotid Artery Disease, Symptomatic Carotid Artery Stenosis, Carotid Artery Stenting, Carotid Plaque Imaging
- Trial name
- CARESTAR (NCT07166731)
- Where
- Germany
- Volunteers
- 536 people
- Sponsor
- Acandis GmbH
Stroke, Ischemic, Transient Ischemic Accident
Urgent Carotid Endarterectomy (CEA) Versus Delayed CEA in Symptomatic Carotid Stenosis (SPREAD-STACI II)
In patients with internal carotid artery (ICA) stenosis of 50% or greater (measured according to the criteria of the North American Symptomatic Carotid Endarterectomy Trial (NASCET)) who have experienced a transient ischemic…
- Conditions
- Stroke, Ischemic, Transient Ischemic Accident, Endarterectomy, Carotid, Stroke Prevention
- Trial name
- Time_to_sCEA (NCT06767657)
- Testing
- CEA (carotid endarterectomy)
- Where
- 2 sites in Italy
- Volunteers
- 456 people
- Sponsor
- Italian Society of Vascular and Endovascular Surgery
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
Evaluation of Balloon Guide Catheter as Proximal Protection During Carotid Artery Stenting (EMBO-PROTECT)
Carotid angioplasty and stenting (CAS) is an effective treatment for carotid artery stenosis but carries a risk of cerebral embolization.
- Trial name
- EMBO-PROTECT (NCT07576790)
- Testing
- balloon guide catheter, No Proximal Protection Group
- Volunteers
- 126 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Carotid Stenosis
Efficacy and Outcome of Carotid Endarterectomy for Symptomatic Carotid Stenosis
Neurovascular complications can result from this procedure usually from thromboembolism from the operated vessel, cerebral hypoperfusion causing ischaemia and, rarely, intracerebral haemorrhage.
- Trial name
- NCT06756360
- Volunteers
- 25 people
- Sponsor
- Assiut University
Oxidative Stress, vonWillebrand Disease
NON CANONICAL ACTIVATION OF BOOD COAGULATION
Cardiovascular diseases (CVD) are the major cause of mortality and morbidity worldwide and most of them are characterized by enhanced generation of active -thrombin (T) from the inactive Prothrombin zymogen (ProT), a reaction…
- Conditions
- Oxidative Stress, vonWillebrand Disease, Carotid Artery Stenosis Symptomatic, Carotid Artery Stenosis Asymptomatic
- Trial name
- NCA-BC (NCT07242521)
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks.
- Trial name
- EVA3S-2 (NCT07054060)
- Testing
- carotid endarterectomy, Carotid artery stenting
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Anne
Carotid Stenosis
Determination of the Best Therapeutic Strategy, Interventional With Best Medical Management (BMM) Versus BMM Alone, for Patients With Symptomatic Moderate <70% Atherosclerotic Carotid Artery Stenosis: the SIMCA Multicenter Randomized Trial
Stroke is one of the leading causes of death and the main cause of long-term disability worldwide. A frequent cause is the narrowing of the carotid artery due to atherosclerosis, known as carotid artery stenosis.
- Trial name
- SIMCA (NCT07839390)
- Testing
- endarterectomy, stenting, Control group
- Volunteers
- 1,440 people
- Sponsor
- Central Hospital, Nancy, France
Carotid Stenosis
Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis
Remote ischemic conditioning (RIC) has emerged as a promising non-invasive strategy to protect the brain, with evidence suggesting its benefit in patients with carotid artery stenting (CAS).
- Trial name
- RICSICAS (NCT07412249)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Carotid Stenosis
Optical Coherence Tomography-Assisted Strategy for Interventional Management of Symptomatic Carotid Stenosis (OASIS-C)
Optical Coherence Tomography-Assisted Strategy for Interventional Management of Symptomatic Carotid Stenosis (OASIS-C) is a multicenter, prospective, exploratory trial using optical coherence tomography to guide endovascular…
- Trial name
- OASIS-C (NCT07886775)
- Testing
- OCT guided endovascular treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Atherosclerosis, Stroke, Ischemic
Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis
One important mechanism of action of GLP1 RA is the improvement in endothelial function, which may be evaluated by the assessment of cerebral vasodilatory reserve (CVR) in patients with severe ICAD.
- Trial name
- RADIANT (NCT07282041)
- Testing
- Dulaglutide
- Where
- Singapore
- Volunteers
- 130 people
- Sponsor
- National University of Singapore