Clinical trials: Symptoms of Depression
Menopause
The Effect of Music Therapy on Sleep Quality and Depression in Menopausal Women
About one-third of women experience no or mild symptoms during their menopausal life, while another third experience moderate symptoms, while the remaining one-third may experience severe symptoms.
- Trial name
- NCT05545761
- Testing
- music therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Meryem Vural Şahin
Long COVID, Long COVID Syndrome
Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue.
- Trial name
- NCT06864156
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Rehabilitacion
Major Depressive Disorder
Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine
A 6-cohort single ascending dose (SAD) study will be conducted in healthy volunteers utilizing a slow-infusion intravenous (IV) route of administration.
- Trial name
- NCT04711005
- Testing
- (2R,6R)-Hydroxynorketamine hydrochloride
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression Symptoms, Anxiety Symptoms
Mirror Journaling App Study
This study has three primary aims: 1) Validate Mirror's Mood Check feature by measuring convergent validity;2) Assess user experience and acceptability metrics (e.g., usability, engagement, satisfaction) of the Mirror app, with a…
- Trial name
- Mirror Journal (NCT07126275)
- Testing
- Mirror App Journaling and Mood Tracking Study
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Child Mind Institute
Aging, Nursing Homes
Effect of Sunlight Exposure and Outdoor Activities on Depression, Cognition and Quality of Life in the Elderly
Background: The transition to long-term care facility can be a stressful and emotional event for the elderly. The evidences showed that the prevalence of depression and the cognition impairment were higher in the…
- Conditions
- Aging, Nursing Homes, Depression in Old Age, Cognitive Impairment
- Trial name
- NCT03304301
- Testing
- sunlight exposure
- Where
- Taiwan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Menopause, Depression
Impact of Hot Flashes on Sleep and Mood Disturbance
We plan to enroll premenopausal women in a trial investigating the impact of hot flashes developed in response to an injection of a gonadotropin-releasing hormone agonist (GnRHa), leuprolide (brand name: Lupron), on sleep…
- Conditions
- Menopause, Depression, Hot Flashes
- Trial name
- NCT01116401
- Testing
- leuprolide
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
This study will evaluate changes in brain energy metabolism due to treatment with escitalopram in people with major depressive disorder.
- Trial name
- NCT00183677
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Trauma, Nervous System
Northwest Therapies Trauma Psilocybin Study Compassionate Use Study
The on-boarding of unregulatable trauma in the United States has reached 20%, which is 1/5 of the population. A population of this magnitude, by definition has now reached an epidemic classification.
- Trial name
- NWTTPS (NCT05042466)
- Testing
- Trauma
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NWTraumatherapies
Depression, Anxiety
Efficacy of a Brief Intervention to Improve Sexual and Gender Minorities' Mental Health: Randomized Controlled Trial.
Experiences of violence, from micro to physical aggressions, have a deleterious impact on mental health. According to the Minority Stress Theory, unfavorable social conditions (such as anticipated and experienced discrimination…
- Conditions
- Depression, Anxiety, Psychological Distress, Social Phobia
- Trial name
- ESCREVA-SE (NCT05349877)
- Testing
- Expressive writing, Self-affirmation
- Where
- Brazil
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Major Depression, Healthy Participants
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Many people with depression do not get better with standard treatments like medications or talk therapy. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation treatment that uses magnetic pulses to stimulate…
- Trial name
- NCT07593222
- Testing
- TMS, D-cycloserine, Dextromethophan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Stress, Anxiety
The Effects of Smell on Mood and Physical Responses
The purpose of this study is to examine the body's response to relaxing and stimulating fragrances commonly used in aromatherapy.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT00097253
- Testing
- Exposure to relaxant and stimulant odors
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Smoking
Effects of Auricular Acupressure and Group Counseling on Smoking Cessation Tobacco Withdrawal Symptoms
Objective The purpose of this study is to examine the effects of auricular acupressure and group counseling with positive psychology and motivational interviewing on smoking cessation and tobacco withdrawal symptoms.
- Trial name
- NCT02916628
- Testing
- group counseling, Auricular acupressure
- Where
- South Korea
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Depression
Dynamic Measures of Neurochemistry in Mood Disorders
The purpose of this study is to understand changes in brain chemical signals when people take antidepressants called sertraline (Zoloft®) and bupropion (Wellbutrin SR, Zyban ®).
- Trial name
- NCT00178828
- Testing
- sertraline, bupropion
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dementia
The Effect of Digital Reminiscence Therapy on People With Mild and Moderate Dementia
In the post-epidemic era, it is necessary to develop support programs for families with dementia in empirical care. The reminiscence therapy was adopted by patients with mild and moderate dementia those intervention have had good…
- Trial name
- NCT05341271
- Testing
- Experimental: digital reminiscence group (DRG), Experimental: general reminiscence group (GRG)
- Where
- Taiwan
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Anxiety, Depressive Symptoms
StriveWeekly: Self-Guided Online Intervention for Anxiety, Depression, and Stress in University Students
This study was a randomized controlled trial of an original online mental health promotion program. This study aimed to: 1) establish program effectiveness by examining symptom change between conditions and 2) examine predictors…
- Conditions
- Anxiety, Depressive Symptoms, Stress, Psychological
- Trial name
- NCT04361045
- Testing
- StriveWeekly
- Where
- United States
- Volunteers
- 1,631 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depression
Comparison Study of Family Practice Interventions for Depression in Adults
To determine if treatment of significant depressive symptoms identified in individuals attending a family practice improves either psychiatric outcome, overall health care costs, or Quality of Life (QOL).
- Trial name
- NCT01975207
- Testing
- Treatment as usual, Internet Intervention, Depression Treatment Pathway
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Anxiety, Depression
Improving Patient and Family Centered Care in Advanced Critical Illness
One in five deaths in the U.S. occurs in or shortly after discharge from an intensive care unit (ICU), typically following decisions made by surrogate decision makers to forego life prolonging treatment.
- Trial name
- PARTNER (NCT01844492)
- Testing
- The PARTNER Intervention, ICU Usual Care Control
- Where
- United States
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Molecular Mechanisms of Pharmacological Action, Depression
Citalopram and Self Emotional Processing
This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mental Disorder
- Trial name
- NCT04169230
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depression in Adolescence
Online MBCT Program for University Students
The goal of this interventional study is to examine the efficacy of the online mindfulness-based cognitive therapy program(MBCT) in youth (18-25 years old) with depressive symptoms.
- Trial name
- NCT05804877
- Testing
- mindfulness-based cognitive therapy, Mental health education
- Where
- Taiwan
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Depression, Postpartum
The Impact of Creative Interventions on Symptoms of Postnatal Depression
Post-natal depression (PND) is anticipated to affect 12.9% of new mothers with at least 75,000 cases per year in the UK alone. However, despite this, there is currently a worrying lack of support for new mothers, with data…
- Trial name
- NCT02526407
- Testing
- Singing, Group play
- Where
- 2 sites in United Kingdom
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Royal College of Music
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