Clinical trials: Synaptic Plasticity
Neuroplasticity in Motor Learning
Neuroplasticity in Motor Learning in Young Adults Under Variable and Constant Practice Conditions
The project aims at providing a better understanding of motor skill acquisition and learning processes. The primary objectives of the study are to determine how practice conditions, i.e., variable and constant practice…
- Trial name
- NMLPC (NCT04921072)
- Testing
- Constant practice conditions, Variable practice conditions
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Transcranial Direct Current Stimulation, Healthy
Maximizing the Impact of Neuroplasticity Using Transcranial Electrical Stimulation Study 1
Non-invasive neuromodulation, such as transcranial direct current stimulation ( tDCS) , is emerging as an important therapeutic tool with documented effects on brain circuitry, yet little is understood about h ow it changes…
- Trial name
- MINUTES (NCT03896425)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sedentary Lifestyle
Exercise, Cognitive Function and Neuroplasticity in Healthy Adults
The overall goal of the proposed study is to compare the effects of 4 weeks of moderate or high intensity aerobic exercise on neuroplasticity, cognitive performance and gait and postural control in sedentary healthy adults.
- Trial name
- NCT02994134
- Testing
- Moderate intensity exercise., High intensity exercise.
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Miami
Auditory Perceptual Disorders, Aging Problems
Neuroplasticity in Auditory Aging_Project 2 Aims 1 and 2
Millions of elderly adults in the USA have age related hearing loss (ARHL), a malady that affects half of adults 60-69 years, and the majority of older adults.
- Trial name
- NCT03475043
- Testing
- Auditory training: temporal cues
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Stroke
High-definition Transcranial Electrical Stimulation for Upper Extremity Rehabilitation
Upper limb hemiparesis is the most common sequelae in patients, severely impacting their independence and quality of life. Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct…
- Trial name
- NCT06409143
- Testing
- HD-tES, UE rehabilitation, HD-tES (Bilateral)
- Where
- 3 sites in Taiwan
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Schizophrenia
Effects of Varenicline on Plasticity in Schizophrenia
This laboratory pilot study will explore the effects of varenicline tartrate on long-term potentiation (LTP)-like mechanisms of (1) the motor cortex and (2) the dorsolateral prefrontal cortex (DLPFC) and working memory in…
- Trial name
- VAR-PAS (NCT01934023)
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cognitive Flexibility, Emotional Regulation
The STRENGTHEN Study
This study uses two different types of interventions including electrical brain stimulation delivered during sleep, and brief, daily meditation training.
- Trial name
- NCT06267521
- Testing
- Healthy Minds Program, Stimulation in Lab, MRI Scanner
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young Adults
The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults
The goal of this clinical trial is to investigate the short-term effect of lower limb BFRT on the somatosensory processing and related changes in SSEP amplitude and latency.
- Trial name
- NCT06762912
- Testing
- Passive application of BFR cuff, Resistance exercise with BFR, Resistance exercise without BFR
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Neuroplasticity
Reaction Time, Cognitive Function and Physical Fitness of Children and Adolescent Soccer Players
Investigation of the effect of an exercise program with visual stimuli on reaction time, cognitive function and physical fitness of children and adolescent soccer players.
- Trial name
- NCT05587907
- Testing
- FitLight Trainer
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Healthy
Probing TBS-induced Neural Plasticity and Associated Effects on Learning
Recent animal research indicates that excitatory brain stimulation opens a time window of increased neural plasticity that permits remodeling of neural representations.
- Trial name
- NCT03756584
- Testing
- Theta-burst stimulation
- Where
- Hong Kong
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dr Georg Kranz
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity.
- Trial name
- NCT03851302
- Testing
- Active Remote Ischemic Conditioning, Isometric hand exercise
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Stroke
Robotic Pedaling Therapy for Targeted Neural Plasticity
The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic…
- Trial name
- NCT03300258
- Testing
- Robotic therapy, Aerobic therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Motor Activity, Motor Neuroplasticity
Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)
Investigating modulation of motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation.
- Trial name
- NCT03481309
- Testing
- anodal tDCS, cathodal tDCS
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Aging
Synaptic Plasticity Imaging With Diffusion MRI
Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique.
- Trial name
- NCT01686516
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
Effects of Gene Polymorphism After Transcranial Cranial Direct Current Stimulation on the Corticobulbar Excitability
This study aims to examine the effects of transcranial direct current stimulation at corticobulbar excitability in individuals with different gene polymorphism.
- Trial name
- NCT03712150
- Testing
- tdcs
- Where
- 2 sites in South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Spinal Cord Injuries
Exoskeleton Training on Balance Control and Turning in Ambulation in Individuals With Incomplete Spinal Cord Injury
This study investigates the impact of exoskeleton training on individuals with incomplete spinal cord injury (iSCI). Investigators focus on assessing how the use of the exoskeleton influences balance control and turning during…
- Trial name
- iSCI (NCT06971510)
- Testing
- Exoskeleton Training, Conventional Physical Therapy
- Where
- 3 sites in China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Women's Health, Brain Plasticity
Effects of Probiotics on Synaptic Plasticity During the Menstrual Cycle
Modulation of our gut microbiota through probiotics, can improve our emotional state, decrease pain sensitivity, improve cognitive processes, increase neurotransmitter levels and alter functional connectivity.
- Trial name
- NCT06213428
- Testing
- Progressive Perfect Probiotic
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation
Measuring rTMS-induced Neuroplasticity With EEG Steady-state Visual-evoked Potentials
The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection…
- Conditions
- Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation, Visual Attention
- Trial name
- NCT05853939
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stroke, Ischemic
Dose-finding Study of Selective Serotonin Reuptake Inhibitors to Enhance Neuroplasticity
The brain is able to change throughout life in response to learning, or injury, or to adapt to changes in the environment, which is known as neuroplasticity.
- Trial name
- NCT04221256
- Testing
- Administration of SSRI escitalopram, Paired Associative stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Burke Medical Research Institute