Clinical trials: Synaptic Plasticity
Schizophrenia, Traumatic Brain Injury
Neuroplasticity in TBI and Schizophrenia
This proposal will examine measures of neuroplasticity (the brain's ability to alter its function or structure in response to changes in the environment or novel experiences) in Veterans with schizophrenia or traumatic brain…
- Trial name
- NVEST (NCT03995368)
- Testing
- Electroencephalography
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Analgesia Disorder, Pain
Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.
Pain exerts a tremendous cost in healthy care, rehabilitation and lost productivity. It is is associated with a wide range of diseases and their social consequences is a public health problem.
- Trial name
- NCT02195271
- Testing
- Transcranial Direct Current Stimulation (tDCS), Melatonin
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Aging, Cognitive Function 1, Social
Effects of Physical and Cognitive Training in Neuroplasticity, Health and Cognition. Movement Project
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging.
- Trial name
- NCT03123900
- Testing
- Physical exercise, Cognitive training, Combined training
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Cerebral Palsy
Robot-assisted Training in Children With CP
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children…
- Trial name
- NCT06450158
- Testing
- Robot (Amadeo)-assisted Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Depression
(GluEsk) Glutamate and Esketamine
Esketamine is the S-enantiomer of racemic ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist. Esketamine and other antidepressant NMDA receptor antagonists are hypothesised to act by producing a rapid increase in brain…
- Trial name
- GluEsk (NCT06432322)
- Testing
- Esketamine nasal spray
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Brain Injuries
D-aspartate and Therapeutic Exercise
An important mechanism responsible for clinical recovery after neurological damage of different types is synaptic plasticity. Nervous tissue can enhance or de-energize inter-neuronal transmission at synaptic level in a lasting…
- Trial name
- DAsp&TerapEx (NCT03228524)
- Testing
- D-Aspartate, Therapeutic exercise
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Bipolar Disorder, Bipolar I Disorder
Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS)
The goal of this study is to evaluate the feasibility and potential benefit of a behavioral intervention designed to improve emotion regulation in individuals with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar Affective Disorder, Bipolar Disorder I
- Trial name
- BRAINS (NCT05683431)
- Testing
- Cognitive Control of Emotion (CCE) Training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Autism
TMS Measures of Plasticity and Excitatory/Inhibitory Ratio as Biomarkers: R-baclofen Effects in Normal Volunteers
Our overall objective is to apply Transcranial Magnetic Stimulation (TMS) to develop measures of human synaptic plasticity and of brain excitatory:inhibitory ratio (E:I ratio), which we propose as novel biomarkers and outcome…
- Trial name
- NCT01172509
- Testing
- R-baclofen
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Gonzalez-Heydrich, Joseph, M.D.
tDCS, Physical Activity + tDCS
Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults
The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current…
- Conditions
- tDCS, Physical Activity + tDCS, Physical Inactivity + tDCS
- Trial name
- EXOPLASTIC (NCT07438808)
- Testing
- Aerobic Exercise, Physical Inactivity, Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Treatment-resistant Depression
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression.
- Trial name
- NCT05607654
- Testing
- active iTBS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cryptogenic Epilepsy
Diffusion Tensor Imaging in Epilepsy With Continuous Spikes and Waves During Sleep
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic encephalopathy. Even if the correlation between the severity of the epilepsy and the cognitive consequences is well established, the mechanisms…
- Trial name
- POCS-DTI (NCT03035513)
- Testing
- Continuous spikes and waves during slow sleep (CSWS)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke, Exercise
The Influence of Exercise on Neuroplasticity and Motor Learning After Stroke
Participants will complete 11 sessions. These include screening, 5 sessions where exercise or rest (according to group assignment) are paired with practice of a motor task, MRI and Transcranial Magnetic Stimulation (TMS) before…
- Conditions
- Stroke, Exercise, Rest
- Trial name
- EX-ML3 (NCT02980796)
- Testing
- Exercise, Practice
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Nicotine Dependence
Transcranial Direct Current Stimulation in a Smoking Cessation Trial
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
- Trial name
- tDCS (NCT01710410)
- Testing
- active transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy, Healthy Adult
Effects of Repetitive Transcranial Magnetic Stimulation on Two Cerebellar Targets
The purpose of this study is to understand how different areas of the cerebellum (a part of the brain) control different functions and how they can be influenced by non-invasive brain stimulation.
- Trial name
- StimCervelet (NCT07561229)
- Testing
- Active rTMS - Lobule VIII, Active rTMS - Crus I/II, Cognitive and Motor Assessment Battery
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Healthy
Parabolic Flight Induced Neuroplasticity Studied With Advanced Magnetic Resonance Imaging Methods
Weightlessness profoundly modifies many physiological systems and especially the nervous system and the vestibular system. The changes in the nervous system are based in part on brain plasticity mechanisms, that is to say on…
- Trial name
- BrainDTI (NCT02517216)
- Testing
- parabolic flight, MRI
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cognitive Function, Neuroplasticity
How Cultural Background Affects Cognitive and Motor Learning Using Virtual Reality
This observational study examined how long-term cultural background is associated with differences in cognitive and motor learning within a virtual reality environment.
- Conditions
- Cognitive Function, Neuroplasticity, Motor Skills, Virtual Reality
- Trial name
- NCT07242937
- Testing
- Virtual reality beat saber training and cognitive and motor assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Stroke With Hemiparesis
Strategies for Recovery of Dexterity Post Stroke
Motor learning can be affected by the sensory difficulties that may be experienced as a result of a stroke. This study will help us better understand what kinds of sensory information can help with the re-learning of grasping…
- Trial name
- NCT01977027
- Testing
- Alternate Hand Training or Affected Hand Training
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stroke, Hemiplegia
Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Brain on the Neurotransmitter Binding
The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) over the brain can modulate the binding of neurotransmitter (GABA in this study) to its receptor using the special PET study.
- Trial name
- NCT01819675
- Testing
- Low frequency rTMS, High frequency rTMS
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Stammering
Modifying Unconscious Tongue Movements in Adults With Developmental Stammer.
This is a pilot randomised controlled trial investigating whether using modification of saccadic eye movements can control lateral unconscious tongue positioning and enhance fluency in adults with a confirmed developmental…
- Trial name
- NCT04310436
- Testing
- Modifying saccades by looking down to naval., Modifying saccades by looking in air.
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute of Technology, Sligo