Clinical trials: Synucleinopathy
Parkinson's Disease
Study of Urate Elevation in Parkinson's Disease, Phase 3
A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial to determine whether oral inosine dosed to moderately elevate serum urate (from ≤5.7 mg/dL to 7.1-8.0 mg/dL) over 2 years slows clinical decline in early…
- Trial name
- SURE-PD3 (NCT02642393)
- Testing
- Inosine
- Where
- 62 sites in United States, Puerto Rico
- Volunteers
- 298 people
- Sponsor
- Michael Alan Schwarzschild
Parkinson Disease, Autonomic Dysfunction
Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease
This is a randomized, single-blinded, triple crossover study focused on determining the feasibility of using transcranial magnetic stimulation (TMS) for treatment of Parkinson's disease related autonomic dysfunction and…
- Conditions
- Parkinson Disease, Autonomic Dysfunction, Depression
- Trial name
- NCT05205772
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Excessive Sleepiness, Parkinson Disease
A 4-Week Study of the Safety, Efficacy, and Pharmacokinetics of JZP-110 [(R)-2-amino-3-phenylpropylcarbamate Hydrochloride] in Subjects With Parkinson's Disease and Excessive Sleepiness
This study is a 4-week, multicenter, randomized, double-blind, placebo-controlled, ascending dose, 4-period crossover study designed to evaluate the safety, tolerability, efficacy, and PK of JZP-110 (75, 150, and 300 mg) in the…
- Trial name
- NCT03037203
- Testing
- JZP-110
- Where
- 25 sites in United States
- Volunteers
- 66 people
- Sponsor
- Jazz Pharmaceuticals
Parkinson's Disease
Cognitive Decline in Non-demented PD
The purpose of this study is to determine the relationship between attention and quality of life and how rivastigmine and atomoxetine alter attention in non-demented persons with Parkinson's disease (PD).
- Trial name
- NCT01340885
- Testing
- Strattera, Exelon
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
BradyXplore Phase II: Bradykinesia Feature Extraction System
Study objectives are to improve motion sensor algorithms for measuring bradykinesia in the clinic and the home, evaluate test-retest reliability of motion sensor algorithms for measuring bradykinesia compared to clinician raters…
- Trial name
- NCT02358876
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Idiopathic Parkinson's Disease
The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease
Levodopa and non-ergot dopaminergic agonists such as pramipexole are both recommended as the first-line symptomatic treatment for early untreated Parkinson's disease (PD), previous clinical trial indicated that initial…
- Trial name
- NCT01470859
- Testing
- pramipexole, Sinemet CR
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital
Parkinson Disease
Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease
The purpose of this pilot study is to generate preliminary data on the impact of the dietary protein pattern on markers of skeletal muscle health and drug efficacy in Parkinson disease.
- Trial name
- NCT05437640
- Testing
- Protein Redistribution Diet, Protein Consistent Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease, Small Intestinal Bacterial Overgrowth
Treating Bacterial Overgrowth in Parkinson's Disease
This study investigates the effect of treating Small Intestinal Bacterial Overgrowth (SIBO) in patients with Parkinson's Disease (PD).
- Trial name
- SIBO-PD (NCT02470780)
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Parkinson's Disease
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
The purpose of this study is to evaluate the safety and effectiveness of Boston Scientific's Vercise Deep Brain Stimulation (DBS) system in the treatment of patients with with advanced, levodopa-responsive bilateral Parkinson's…
- Trial name
- INTREPID (NCT01839396)
- Testing
- Deep Brain Stimulation
- Where
- 22 sites in United States
- Volunteers
- 313 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease
Study of Azilect® (Rasagiline) in Levodopa-treated Parkinson's Disease Patients With Motor Fluctuations in Korea
To evaluate the efficacy of a fixed dose of Azilect® (1 mg/day) vs placebo as assessed by the change from baseline in mean total daily OFF time during 18 weeks of treatment in levodopa-treated Parkinson's Disease (PD) patients…
- Trial name
- NCT01268891
- Testing
- Azilect®
- Volunteers
- 132 people
- Sponsor
- H. Lundbeck A/S
Parkinson Disease, Constipation
Orally Administered ENT-01 for Parkinson's Disease-Related Constipation Follow-on Safety "Roll-over" Study (Rollover)
This study will be conducted as an open-label safety follow-on to a multi-center, double-blind, randomized study. All subjects who participated in the randomized study will be offered participation in this unblinded, single-arm…
- Trial name
- Rollover (NCT04483479)
- Testing
- Active Investigational Treatment ENT-01
- Where
- 18 sites in United States
- Volunteers
- 27 people
- Sponsor
- Enterin Inc.
Parkinson Disease
Exercise and Parkinson's: Comparing Interventions and Exploring Neural Mechanisms
Parkinson disease (PD) is characterized by substantial disability and reduced quality of life, both of which can be attributed in large part to difficulties with walking.
- Trial name
- NCT01768832
- Testing
- Treadmill, Tango, Stretching
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease
Telemedicine Intervention to Improve Physical Function
This project is investigating whether a one-year in-home exercise program will reduce the rate of falls and improve strength and quality of life in patients with Parkinson's disease.
- Trial name
- NCT01639469
- Testing
- Structured exercise, Lifestyle exercise
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Freezing of Gait
Moving Mindfully for Freezing in Parkinsons
The investigators will modify and evaluate the feasibility of a mindfulness intervention among people living with Parkinson disease (PD) and freezing of gait (FOG).
- Trial name
- MMR34 (NCT05309083)
- Testing
- Mindfulness Based Walking Therapy (MBWT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease
A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease
The purpose of this study is to evaluate the effect of AMPYRA on a number of symptoms in Parkinson's disease. AMPYRA is a medication approved by FDA for gait dysfunction in multiple sclerosis.
- Trial name
- NCT01491022
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Miami
Parkinson Disease
Effect of Simultaneous Dual Stimulation on Freezing of Gait in Parkinson's Disease
The purpose of this study is to investigate the effect of dual-mode non-invasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and…
- Trial name
- NCT02850159
- Testing
- rTMS and tDCS, rTMS
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Parkinson's Disease (PD)
An Open-label Study in Healthy Male Subjects to Assess the Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 9-1067 and Metabolites
The purpose of this study is to determine the rate and routes of excretion of OPC and the mass balance in urine, faeces and expired air.
- Trial name
- NCT02169427
- Testing
- OPC
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy
Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
The purpose of this study is to see whether droxidopa is effective in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy…
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy, Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency
- Trial name
- NOH302 (NCT00633880)
- Testing
- Droxidopa
- Where
- 54 sites in United States, Australia and 2 more
- Volunteers
- 181 people
- Sponsor
- Chelsea Therapeutics
Parkinson's Disease
A Long-Term Extension Trial From Phase II/III of SPM 962 in Early Parkinson's Disease Patients
Safety of SPM 962 in a once-daily repeated long-term treatment in Parkinson's disease patients who are not concomitantly treated with L-dopa will be investigated with a doses.
- Trial name
- NCT01628965
- Testing
- SPM 962
- Where
- 7 sites in Japan
- Volunteers
- 143 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Parkinson's Disease
A Study of E2007 In Patients With Parkinson's Disease
Phase IIb open-label extension study for patients with Parkinson's Disease. All patients will receive active study drug. The study will involve outpatient visits only.
- Trial name
- NCT00427011
- Testing
- E2007
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Eisai Inc.