Clinical trials: System Sclerosis
Multiple Sclerosis
MicroRNA-150 and microRNA-155 in Multiple Sclerosis
A study To analyse the expression of circulating miR-150 and miR-155 in serum of MS patients, Evaluate the serum levels of oligoclonal bands, neurofilaments and chitinase-3-like-1 in serum of MS patients, and Investigate the…
- Trial name
- NCT04300543
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assiut University
Interstitial Lung Disease, Systemic Autoimmune Disease
ILD-SARDs Registry and Biorepository
A complex interaction between demographic, environmental and genetic mechanisms impact the onset, severity and outcome of ILD-SARDs through dysregulation of the immune system and lung pro-biotic pathways.
- Conditions
- Interstitial Lung Disease, Systemic Autoimmune Disease, Rheumatic Diseases, Rheumatic Arthritis
- Trial name
- ILD-SARDs (NCT05007340)
- Testing
- Blood draws, Other biological samples to biobank (skin, lung and muscle biopsies; bronchoalveolar lavage (BAL fluid), Clinical data collection
- Where
- Canada
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Multiple Sclerosis, CVA
Feasability, Validty and Reliability of Inertial Sensors
This study has 3 aimes: 1. To investigate the feasibility of using IMUs (Xsens, MVN Studio) during functional tasks to assess upper limb kinematics in pwMS and stroke survivors.
- Trial name
- NCT03668990
- Testing
- IMUs (Xsens, MVN Studio)
- Where
- 2 sites in Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Healthy
The Efficacy of Vitamin K2 n Human Osteoporosis, Blood-vessel Calcification and Sclerosis
This study used the generally recognized as safe (GRAS) grade of Bacillus subtilis natto to produce Vitamin K2, Menaquinone-7(MK-7), via fermentation, for functional evaluation.
- Trial name
- NCT01928134
- Testing
- Vit K2+ Vit D3+ calcium carbonate (CaCO3), Vit K2+CaCO3
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Demyelinating Disorders, MCI
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple…
- Conditions
- Demyelinating Disorders, MCI, Alzheimer's Disease (AD), MS (Multiple Sclerosis)
- Trial name
- NCT06999434
- Testing
- [ 18F]3F4AP, [18F]MK6240, [11C]PIB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yale University
Amyotrophic Lateral Sclerosis
Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients
This observational study explored the connection between the gut microbiota and the brain in patients with amyotrophic lateral sclerosis (ALS), specifically the modulation of short-chain fatty acids during disease progression and…
- Trial name
- IMPACT-ALS (NCT07178067)
- Testing
- Mediterranean diet
- Where
- Romania
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Multiple Sclerosis
Technology-assisted Conscientiousness Therapy for People With Multiple Sclerosis
This is a validation study of a conscientiousness-based phone app intervention strategy to help people with their health management and employment.
- Trial name
- TACT-MS (NCT04953689)
- Testing
- Conscientiousness Coach
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Scleroderma, Systemic
Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study
The purpose of the study is to assess skin blood flow after non-invasive local administration of treprostinil by using a low-intensity current (i.e.
- Trial name
- TIPPS (NCT01554540)
- Testing
- Cutaneous iontophoresis of treprostinil
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Multiple Sclerosis
Investigation of Novel Immunological Biomarkers by Mass Cytometry in Patients With Early Multiple Sclerosis (CISCO)
The objective of CISCO is therefore to identify prognostic biomarkers of MS activity in early-stage patients.
- Trial name
- CISCO (NCT04510350)
- Testing
- Biomarkers analysis
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Primary Progressive
The Effect of Neurorehabilitation Therapy on Postural Control, Mobility and Quality of Life in Multiple Sclerosis Patients
Abstract Introduction: Postural control disorders are the most common motor disorder associated with multiple sclerosis. Objective: The aim of this study is to demonstrate the potential for improvement of postural control, motion…
- Trial name
- NCT03424538
- Testing
- Neurorehabilitation, Physiotherapy
- Where
- Hungary
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Multiple Sclerosis
Sonification Embodied Associations
The objective of this study to investigate, if learning and recall of a sequence of body movements (steps that realize a pattern on the ground) can be improved by self-produced music (having particular melodic-structures in…
- Trial name
- NCT03931278
- Testing
- learning and recall of a sequence of body movements
- Where
- 3 sites in Belgium
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Pediatric Multiple Sclerosis
Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis
The purpose of this study is to better understand multiple sclerosis (MS) in children and adolescents, to learn if it differs from adult MS and to investigate if genes or environmental exposures or a combination of both put…
- Trial name
- NCT01396343
- Where
- 17 sites in United States
- Volunteers
- 1,276 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Amyotrophic Lateral Sclerosis
Reinnervation and Neuromuscular Transmission in ALS
The aim of this study is to describe the changes in the neuromuscular connection in patients with amyotrophic lateral sclerosis (ALS). The study consist of three substudies that have the following main hypothesis: 1.
- Trial name
- RANTAL (NCT06219759)
- Testing
- Observational study
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis
Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS)
The involvement of Lymphocyte type B in Amyotrophic lateral sclerosis (ALS) patients will be compared to lymphocyte in healthy subjects.
- Trial name
- NCT00846560
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Multiple Sclerosis
A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple Sclerosis
This was a Phase 2, randomized, double-blind, placebo-controlled 2 parallel-arm study to assess the effect on serum neurofilament light chain (sNfL), safety and tolerability of oral SAR443820 compared to placebo in male and…
- Trial name
- NCT05630547
- Testing
- SAR443820
- Where
- 35 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis
Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Normal Population
This study intends to explore the levels of MSRV expression by analyzing the levels of MSRV transcripts in blood, as well as the levels of the MSRV-Env protein in serum in the normal population.
- Trial name
- CONTROL (NCT01804660)
- Testing
- No study treatments administered
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GeNeuro Innovation SAS
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
MS-ResearchBiomarkerS
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- MS-ReBS (NCT05204459)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Autoimmune Diseases, Relapsing Multiple Sclerosis
Fecal Microbial Transplantation in Relapsing Multiple Sclerosis Patients
The proposed randomized, open label, with treat as usual control group (standard treatment or any disease modifying drugs), crossover phase II study will be conducted in 40 patients (n=20 per group) with the relapsing forms of…
- Trial name
- NCT03183869
- Testing
- Fecal microbiota
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Imaging Biomarkers in ALS
The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3…
- Trial name
- NCT02567136
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Volunteers
Safety Study of GNbAC1 Monoclonal Antibody in Healthy Male Volunteers
In this clinical study, the safety and tolerability of GNbAC1 as a treatment for MS patients will be evaluated in healthy male volunteers.
- Trial name
- NCT02452996
- Testing
- GNbAC1
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GeNeuro Innovation SAS