Clinical trials: Systemic Infection
Sepsis
Role of Enteral Lactoferrin as an Adjuvant for Prevention of Sepsis Among Preterm Neonates
Lactoferrin (LF) is a multifunctional glycoprotein and is naturally present in various body secretions, including human milk, tears, saliva, airway mucus, and the secondary granules of neutrophils 1-2.
- Trial name
- NCT07480434
- Testing
- Bovine Lactoferrin Supplement
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Zartash Sial Paeds Med
Wound Healing Disturbance of Port-A
Using a Thermal Imaging System to Evaluate the Wound of Port-A and the Relationship Between Thermal Images and Infection
Permanently implantable venous ports (Port-A) is very important to patients receiving chemotherapy. It not only provides a reliable route to administrate intravenous drugs, and it also requires minimal care when it is not in use.
- Trial name
- NCT02072265
- Testing
- Infrared thermal images
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Sepsis
Registration of Sepsis Patients in the Emergency Department
1) Establish a clinical data database for sepsis patients in the Emergency Department of the First Hospital of Jilin University.
- Trial name
- RSP (NCT06068192)
- Testing
- no intervention
- Volunteers
- 500 people
- Sponsor
- The First Hospital of Jilin University
Septic Shock, Morality
Shock Indices Use for Early Mortality From Septic Shock
Background and Rationale: Sepsis is a universal healthcare problem with a high incidence and mortality. Improvement in early sepsis recognition and management has reduced the 28 day- and in-hospital mortality in the last two…
- Trial name
- NCT05088109
- Testing
- early mortality prediction using septic shock indices
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Cairo University
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant and in Healthy Volunteers
RATIONALE: The influenza vaccine may help prevent flu in patients who have undergone stem cell transplant. PURPOSE: This clinical trial is studying how well the influenza vaccine works in preventing flu in patients who have…
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00952185
- Testing
- cytology specimen collection procedure, fluorescent antibody technique, assessment of therapy complications
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Chronic Myeloproliferative Disorders, Leukemia
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis
RATIONALE: Drugs used in chemotherapy, such as 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Nonneoplastic Condition
- Trial name
- NCT00132015
- Testing
- tanespimycin
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sepsis, Infection
Heparin Binding Protein in Early Sepsis Diagnosis
The primary objective of this study is to use heparin-binding protein (HBP) concentration to indicate the presence, or outcome, of sepsis over 72 hours after ED admission.
- Trial name
- PROMPT (NCT03295825)
- Testing
- Biomarker
- Where
- 6 sites in Greece
- Volunteers
- 400 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Bowel Perforation, Abscess
Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction In previous…
- Conditions
- Bowel Perforation, Abscess, Leakage, Peritonitis
- Trial name
- NCT01784458
- Volunteers
- 46 people
- Sponsor
- University of Ulsan
Sepsis-Associated Encephalopathy
Establishment of a Cohort of Patients With Sepsis-associated Encephalopathy (SAE)
In this study, the researcher involved the sepsis patients(defined by sepsis 3.0) in Peking Union Medical College Hospital. The SAE was defined as the Glasgow Coma Scale (GCS) score of less than 15 and the Non-SAE group GCS = 15.
- Trial name
- SAE (NCT04230447)
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Yi Li, MD
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
EVLWI Exhibits Pulmonary and Systemic Permeability in Sepsis Related ALI/ARDS
To investigate the possible mechanisms of pulmonary and systemic permeability change including cytokine, extravascular lung water index (EVLWI), and oxygenation parameters in patients with sepsis related acute lung injury…
- Trial name
- NCT01694147
- Testing
- PiCCO monitoring system
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Sepsis
Clinical Evaluation of the Effect of Metformin in Sepsis
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is considered a condition that arises when the body's response to an infection injures its own tissues and organs.
- Trial name
- NCT05979038
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- German University in Cairo
Sepsis - to Reduce Mortality in the Intensive Care Unit
Procalcitonin Increase Identifies Critically Ill Patients at High Risk of Mortality
Procalcitonin, a marker of infection has often been compared to clinical pictures as for instance "clinical sepsis". This has given som problems in the interpretation of these studies, because of the lack of good Gold Standards…
- Trial name
- NCT00144638
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Danish Procalcitonin Study Group
Covid19, Cytokine Storm
Menstrual Blood Stem Cells in Severe Covid-19
In this randomized controlled trial (RCT), severe cases of COVID-19 infection will be treated with secretome of menstrual blood stem cells.
- Trial name
- NCT05019287
- Testing
- Allogeneic human menstrual blood stem cells secretome, Intravenous saline injection
- Where
- Iran
- Volunteers
- 29 people
- Sponsor
- Avicenna Research Institute
Bacteremia
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT
Bacteremia is a leading cause of mortality and morbidity in critically ill adults. Although bacteria in the bloodstream (bacteremia) may arise from variable infectious foci (most commonly central vascular catheter related, lung…
- Trial name
- BALANCE (NCT02261506)
- Testing
- 7 days of adequate antibiotic treatment durations, 14 days of adequate antibiotic treatment durations
- Where
- 17 sites in Canada
- Volunteers
- 115 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sepsis, Acute Lung Injury
Statins for Acutely Injured Lungs From Sepsis
Objective: assess the efficacy and safety of oral rosuvastatin in patients with sepsis-induced Acute Lung Injury (ALI). Hypothesis: Rosuvastatin therapy will improve mortality in patients with sepsis-induced ALI.
- Trial name
- SAILS (NCT00979121)
- Testing
- Rosuvastatin
- Where
- 40 sites in United States
- Volunteers
- 745 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction, Inflammation
Inflammation in Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand.
- Conditions
- Myocardial Infarction, Inflammation, Critical Illness
- Trial name
- NCT02385487
- Where
- United States
- Sponsor
- NYU Langone Health
Sepsis, Shock, Septic
Sepsis Assessment in Belgian Emergency Rooms
To validate the use of the Heparin Binding Protein (HBP) concentration to assist in the evaluation of patients admitting to the emergency department with suspected infection.
- Conditions
- Sepsis, Shock, Septic, Severe Sepsis
- Trial name
- SABER (NCT02424721)
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Axis Shield Diagnostics Ltd
Septic Shock
Effect of Shenfu Injection on the Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective single-center clinical trial aims to evaluate the circulatory and microcirculatory effects of Shenfu Injection in patients with septic shock.
- Trial name
- NCT07603024
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Severe Sepsis, Septic Shock
A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock
The two co-primary objectives of this study are to assess in Japanese patients with severe sepsis and/or septic shock: 1) the safety and tolerability of two different doses of intravenous AZD9773 and 2) the PK of AZD9773.
- Trial name
- NCT01144624
- Testing
- AZD9773
- Where
- 7 sites in Japan
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
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