Clinical trials: Systemic Vascular Resistance
Sevoflurane, Cardiac Output
The Effect of Sevoflurane on Haemodynamics
Cardiac output (CO) is measured using Mostcare. Mean systemic filling pressure (MSFP) and vascular resistances are calculated using venous return curves constructed by measuring steady-state arterial and venous pressures and…
- Conditions
- Sevoflurane, Cardiac Output, Venous Return, Vascular Resistance
- Trial name
- NCT06707077
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Fudan University
Chronic Kidney Insufficiency, Hypertension
Renal and Systemic Vascular Resistance in Chronic Kidney Disease (CKD)
Patients with reduced kidney function have a higher risk of heart disease and death. Studies have shown that blood vessels in patients with hypertension change with a decrease of lumen size and growth of the vessel wall.
- Conditions
- Chronic Kidney Insufficiency, Hypertension, Vasodilation
- Trial name
- RenVas (NCT01380717)
- Testing
- Beta-blocker, ACE-inhibitor, Calcium Channel Blockers, ACE-Inhibitor
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hemodynamics Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.
The study objective is to examine if a high propofol dose is non-inferior to a low dose in respect to hemodynamic stability in healthy patients during induction of general anesthesia with propofol and remifentanil.
- Conditions
- Hemodynamics Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- PH (NCT03861364)
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Helse Fonna
Systemic Lupus Erythematosus
Aspirin Resistance in Systemic Lupus Erythematosus (SLE)
This study examine whether patients with lupus respond to aspirin , and if not, if that is related to inflammation. We examine the ability of aspirin to inhibit the production of thromboxane in patients with lupus and controls…
- Trial name
- NCT00731302
- Testing
- aspirin and meloxicam
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiovascular Diseases, Vascular Diseases
Influence of Age, Weight and Ethnic Background on Blood Pressure
Hypertension, also known as high blood pressure, is a chronic medical condition, in which the blood pressure is elevated. This is a common condition, which can lead to severe complications such as cardiovascular disease, heart…
- Conditions
- Cardiovascular Diseases, Vascular Diseases, Hypertension
- Trial name
- AWE (NCT03014791)
- Testing
- Brief lifestyle/medical history questionnaire, Anthropometric measures, Blood pressure and arterial stiffness
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hemodynamic Monitoring
Starling Registry Study
Hemodynamic optimization of critically ill patients is a goal for clinicians in order to afford the patient the best possible outcomes.
- Trial name
- NCT04648293
- Testing
- Starling
- Where
- 9 sites in United States
- Volunteers
- 1,207 people
- Sponsor
- Baxter Healthcare Corporation
Coronary Artery Disease, Aortic Valve Disease
Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer
Swan Ganz catheter-Edwards Lifesciences obtains values of cardiac output/index and systemic vascular resistance/index using the mean artery pressure of either radial or femoral artery.
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- RaFe (NCT06112561)
- Testing
- CO/CI/SVR
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Essential Hypertension, High Blood Pressure
Intensive Vasodilator Therapy in Patients With Essential Hypertension
The purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion and reduce the total peripheral resistance in patients with ongoing treatment for essential hypertension.
- Trial name
- Vasomore (NCT01180413)
- Testing
- Amlodipine, Ramipril, Lercanidipine
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Aarhus University Hospital
Hypertension, Renal
Transcatheter Renal Artery Sympathetic Denervation Observational Study
Hypertension is a common health problem that affects millions of people in the world. Poorly controlled blood pressure (BP) leads to cardiovascular, cerebrovascular and renal complications.
- Trial name
- NCT05744986
- Testing
- SYMPICITY Spyral RENAL DENERVATION (RDN) SYSTEMTM
- Where
- 2 sites in Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Hereditary Periodic Fever Syndromes, Cryopyrin-associated Periodic Syndromes (CAPS)
Ilaris NIS in Korea
This is a study to evaluate safety and effectiveness of Ilaris in adult and pediatric patients receiving the drug in a clinical setting for any of the following indications, Hereditary Periodic Fever Syndromes…
- Conditions
- Hereditary Periodic Fever Syndromes, Cryopyrin-associated Periodic Syndromes (CAPS), Colchicine Resistance Familial Mediterranean Fever (crFMF), TNF Receptor Associated Periodic Syndrome (TRAPS)
- Trial name
- REASSURE (NCT06838143)
- Testing
- Ilaris
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
Metabolic Syndrome
Green Coffee Extract Supplementation and Oxidative Stress, Systemic and Vascular Inflammation
Metabolic syndrome (Mets) is defined as the collection of risk factors contributing to type 2 diabetes mellitus and cardiovascular disease. Mets is accompanied by oxidative stress and low-grade inflammation.
- Trial name
- NCT03265184
- Testing
- green coffee extract
- Volunteers
- 48 people
- Sponsor
- National Nutrition and Food Technology Institute
Syncope
Exercise and Prevention of Syncope: EXPOSE
The purpose of this study is to determine whether eight weeks of exercise performed at an intensity of approximately 65% VO2max will improve symptoms associated with fainting (vasovagal syncope).
- Trial name
- NCT00203593
- Testing
- Exercise, Blood volume, VO2max test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Healthy
Effects of the Cornelian Cherry Supplementation on the Selected Physiological Parameters in Marathon Runners
Growing body of evidence indicates favorable effects of Cornus mas (Cornelian cherry) supplements on cardiometabolic risk, including the improvement of HDL and glycemic indices, in line with vascular benefits.
- Trial name
- NCT07194720
- Testing
- Cornus mas lyophilisate
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Healthy Young Adults, Healthy Adult Participants
Foam Rolling and Blood Pressure
Foam rolling (FR) has emerged as a widely adopted modality among rehabilitation practitioners and physically active populations.
- Conditions
- Healthy Young Adults, Healthy Adult Participants, Healthy Participants, Normotensive
- Trial name
- NCT07520474
- Testing
- Foam Rolling Intervention (FR)
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Preeclampsia
A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia
The purpose of this study is a systematical registration of hemodynamic measurements (cardiac output, blood pressure and systemic vascular resistance) in women with serious preeclampsia.
- Trial name
- NCT00403572
- Volunteers
- 8 people
- Sponsor
- Oslo University Hospital
Arterial Hypertension, Resistant Arterial Hypertension
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation
It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and…
- Trial name
- NCT03243045
- Testing
- Renal sympathetic denervation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Heart; Surgery, Heart, Functional Disturbance as Result
The Role of Modified Ultrafiltration Following Open Heart Surgery
This study aims to investigate the effect of combining conventional ultrafiltration and modified ultrafiltration compared to conventional ultrafiltration alone in patients who underwent open heart surgery.
- Trial name
- NCT06085066
- Testing
- Conventional Ultrafiltration alone on Cardiopulmonary bypass, Conventional Ultrafiltration followed by Modified Ultrafitration on Cardiopulmonary bypass
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Indonesia
Systemic Lupus Erythematosus, Insulin Resistance
Insulin Resistance and Atherosclerosis in Women With Lupus
This study will test the effects of insulin resistance on atherosclerosis (hardening of the arteries) in women who have systemic lupus erythematosus, more commonly known as lupus.
- Conditions
- Systemic Lupus Erythematosus, Insulin Resistance, Atherosclerosis
- Trial name
- NCT00544102
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Shock, Septic
The Value of Peripheral Arterial Resistive Index in Evaluation of Tissue Perfusion in Patients With Septic Shock
In patients with septic shock, routine arterial blood pressure and central venous pressure are monitored in ICU. Conventional methods such as blood pressure and central venous pressure in septic patients cannot provide sufficient…
- Trial name
- NCT05902273
- Testing
- hemodynamic monitoring, resistive index, Pleth variability index
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Raynaud's Disease, Raynaud Phenomena
Open Label Treprostinil Raynaud's Study
Raynaud's phenomenon is a condition where the blood vessels in participants fingers and toes get too narrow when cold or stressed.
- Conditions
- Raynaud's Disease, Raynaud Phenomena, Raynauds
- Trial name
- NCT07112183
- Testing
- Oral treprostinil (UT-15C) sustained release tablets
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital