Clinical trials: Systolic Murmurs
Cardiovascular Risk Factors
Beneficial Impact of Orange Juice Consumption on Risk Factors Associated With Cardiovascular Diseases
The primary aim is to examine both the acute and chronic effects of hesperidin consumption from 100% Florida orange juice in various doses on functional and systemic markers associated with cardiovascular disease (CVD) risks.
- Trial name
- CITRUS (NCT02479568)
- Testing
- Control, 100% Florida OJ, 100% Florida OJ-enriched
- Where
- Spain
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Chronic Kidney Diseases, Left Ventricular Systolic Dysfunction
Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography
The goal of this observational study is to learn about the value of multimodal ultrasound in early detection of left ventricular systolic dysfunction in patients with chronic kidney disease(CKD).
- Trial name
- NCT06221891
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Diastolic Dysfunction, Systolic Dysfunction
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions.
- Conditions
- Diastolic Dysfunction, Systolic Dysfunction, Diastolic Heart Failure
- Trial name
- CardiacAging (NCT05408559)
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Acute Kidney Injury (Nontraumatic)
Comparison Between Right and Left Ventricular Systolic Dysfunction as a Risk Factors for Aki in Critical Care Patients
The cardio renal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently.
- Trial name
- NCT03369561
- Testing
- Serum urea and creatinine and the calculated e GFR
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Niue
Ambient air temperatures in the Pacific have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06570993)
- Testing
- Cool roof
- Where
- Niue
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Cardiac Rehabilitation, Rheumatoid Arthritis
The Effects of Cardiac Rehabilitation Programme in Hypertensive Rheumatoid Arthritis Patients
The aim of this study is to investigate the beneficial impacts of the 6-week standardized CR program applied to hypertensive RA patients whose disease activity is under control with regular pharmacological treatment.
- Conditions
- Cardiac Rehabilitation, Rheumatoid Arthritis, Hypertension
- Trial name
- CARDIRA (NCT06295848)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Heart Murmurs, Mitral Valve Prolapse
Automated Algorithm Based Analysis of Phonocardiograms of Newborns
The purpose of this double-blind pivotal clinical utility study is to determine on a large patient population whether heart murmurs can be reliably detected with high sensitivity and specificity using a locked, automated…
- Conditions
- Heart Murmurs, Mitral Valve Prolapse, Systolic Murmurs
- Trial name
- NCT02105480
- Testing
- Computer aided auscultation (CAA)
- Where
- Austria
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Hypovolemia
Detecting a Volume Deficit During Spontaneous Breathing
13 healthy volunteers (4 females) were tilted 45° head-up while breathing through a facemask fitted with an inspiratory and expiratory resistor.
- Trial name
- NCT02549482
- Testing
- Respiratory resistor
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Hypertension, Pregnancy
Comparison Fetal Hemodynamic Measurements Antihypertensive Versus Control
This is a prospective case-control study to evaluate women who are pregnant and take antihypertensive medication for fetal hemodynamics (middle cerebral artery peak systolic flow and umbilical artery Doppler systolic to diastolic…
- Trial name
- NCT00759278
- Testing
- ultrasound evaluation in pregnancy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Hypertension
Vitamin D and Blood Pressure
Vitamin D is a natural nutrient in normal daily diet. It can also be made in the skin after exposure to sunlight and is essential for maintaining normal calcium balance.
- Trial name
- NCT00459563
- Testing
- Vitamin D, calcitriol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Atlanta VA Medical Center
Vagus Nerve Stimulation
Vagus Nerve Stimulation Effects on Autonomic Nervous System Activity
Transcutaneous Auricular Vagus nerve stimulation may be successful in cardiac modulation because of the cardiac connections of the vagal nerve.
- Trial name
- NCT06086236
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Hypertensive Disorders of Pregnancy, Pre-eclampsia
Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP)
Hypertensive disorders of pregnancy frequently fail to resolve at delivery. A substantial proportion of women remain hypertensive at the six-week postnatal review, postpartum eclampsia occurs days to weeks after birth, and a…
- Conditions
- Hypertensive Disorders of Pregnancy, Pre-eclampsia, Postpartum Hypertension, Puerperal Disorders
- Trial name
- OPHELIA-PP (NCT07841795)
- Where
- Italy
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Umblical Artery Doppler in Term Pregnancy
Umblical Artery Systolic \Diastolic Ratio and Amniotic Fluid Index in Prediction of Fetal Outcome in Term Pregnancy
Antepartum fetal surveillance is the cornerstone of management in pregnancy. [1] It is done primarily to reduce the incidence of adverse fetal outcomes. It minimizes morbidity by optimizing the timing of delivery.
- Trial name
- NCT06347913
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pulmonary Disease, Chronic Obstructive
To Evaluate Effects of GSK2256294 on Pulmonary Artery Pressure in Healthy Volunteers Under Normoxic and Hypoxic Conditions
The study evaluates the effect of GSK2256294 exposure at steady state on pulmonary artery systolic pressure (PASP) in healthy volunteers, under hypoxic conditions, after 7 days of dosing.
- Trial name
- NCT02262689
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stroke, Acute
Manipulation of Arterial Pressure in Acute Ischemic Stroke
This is a controlled clinical trial among non thrombolysed acute ischemic stroke patients to determine the effects of three levels of arterial pressure on death and neurological disability.
- Trial name
- MAPAS (NCT00848770)
- Testing
- Esmolol, Sodium Nitroprussiate (NPS) or Norepinephrine (NOR), Esmolol, NPS or NOR, manipulation of SAP
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Murmurs, Pathologic Murmurs
eMurmur ID - Clinical Performance Evaluation
The differentiation between innocent and pathologic murmurs through traditional auscultation can often be challenging, which in the end makes the diagnosis strongly dependent on the clinitians experience and clinical expertise.
- Conditions
- Heart Murmurs, Pathologic Murmurs, Innocent Murmurs, Congenital Heart Defect
- Trial name
- NCT03227848
- Testing
- Automated Heart Murmur Detection AI
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Blood Pressure
Non-invasive Continuous Blood Pressure Monitoring
The Boppli device was designed to provide continuous non-invasive blood pressure (cNIBP) monitoring for infants, including neonates, in intensive care settings by detecting systolic, diastolic, and mean arterial blood pressure…
- Trial name
- NCT05224011
- Testing
- Boppli Infant Blood Pressure Monitor
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- PyrAmes Inc.
Left Ventricular (LV) Systolic Dysfunction
AI-Enabled Electrocardiogram-Guided Guideline-Directed Medical Therapy on Incident Left Ventricular Dysfunction: A Target Trial Emulation Study
This multicenter retrospective study evaluates whether artificial intelligence-enabled electrocardiography (AI-ECG) can identify individuals at high risk for left ventricular dysfunction and whether targeted guideline-directed…
- Trial name
- NCT07355023
- Testing
- Guideline-directed medical therapies
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Cardiovascular Responses in Elderly With Isolated Systolic Hypertension
Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension
Aim to study the exercise responses to both static and dynamic exercise in elderly people with and without essential isolated systolic hypertension, seeking to identify potentially dangerously high responses
- Trial name
- NCT02270216
- Testing
- static hand grip exercise, cycling exercise
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sahachat Aueyingsak