Clinical trials: T1D
Healthy, Type 1 Diabetes
Subcutaneous Administration of Lisofylline to Healthy Normal Subjects and Subjects With Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Autoimmune diseases happen when the immune system does not identify part of the body as belonging to it.
- Trial name
- NCT00896077
- Testing
- Lisofylline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DiaKine Therapeutics, Inc.
Type 1 Diabetes
Effect of Hyperglycemia on Gastric Emptying Interactions With Pramlintide
To examine the influence of acute glycaemia (normoglycaemia and hyperglycaemia) on gastric emptying kinetics in patients with type 1 diabetes and non diabetic subjects when treated with subcutaneous (SC) injections of pramlintide.
- Trial name
- NCT00489645
- Testing
- pramlintide
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Type 1 Diabetes
The Integration of Physical Activity Into the Clinical Decision Process of People with Type 1 Diabetes
Every person with type 1 diabetes needs personalized advice to integrate physical activity into daily diabetes management. The purpose of this study is to collect data on food intake, physical activity, glucose levels and insulin…
- Trial name
- ENHANCED1 (NCT05670366)
- Testing
- Activity tracker and chest strap, Diary app
- Where
- Belgium
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- prof dr Pieter Gillard
Type1diabetes, Type1 Diabetes Mellitus
Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics
Investigators aim to further the understanding of environmental factors that underlie the progression to Type 1 diabetes (T1D). Dysbiosis, defined as alterations in intestinal microbiota composition and function, has been…
- Trial name
- NCT03423589
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type 1 Diabetes Mellitus (T1DM), Healthy Control
Environmental Determinants of Type 1 Diabetes Risk
To analyze the environmental risk factors for type 1 diabetes in China.
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Healthy Control, Relatives to/Carers of Patients
- Trial name
- NCT07835724
- Where
- China
- Volunteers
- 11,240 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes
A Trial Investigating the Accuracy of Continuous Glucose Monitor Systems ("Supersapiens" Abbott Libre Sense and Dexcom G6) During Exercise in People With Normal Glucose Tolerance
A two-phase, observational trial in an exercise laboratory and a prospective real-world setting to test the hypothesis that The Libre Sense Glucose Sport device has acceptable accuracy in people with normal glucose tolerance and…
- Trial name
- SuperComEx (NCT06034574)
- Testing
- Continuous glucose monitoring
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes Mellitus
Comparative Measurement of Microcirculation and Other Parameters With the Vital USA VitalDetect™ in Patients With Diabetes Mellitus Type 1 and Type 2 Versus Healthy Participants
The purpose of this clinical study is to optimize the measurement algorithm of the Vital USA VitalDetectTM in measuring the microcirculating blood flow.
- Trial name
- NCT06063759
- Testing
- VitalDetect
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sciema UG
Diabetes Mellitus, Type 1, Ischemia
Non-enhanced Magnetic Resonance Angiography of Diabetic Ischemic Lower Limbs
Diabetic foot ulcers often progresses after many years of diabetes where the patients system is so damaged that normal heeling of ulcers cannot happen.
- Conditions
- Diabetes Mellitus, Type 1, Ischemia, Foot Ulcer
- Trial name
- NCT01614379
- Where
- 2 sites in Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diet Habit, Type I Diabetes
How Type I Diabetes Responds to Different Diets (Normoglucidic or Ketogenic) During Physical Activity at Altitude
To date, no study has shown the effects of diets (normoglucidic or ketogenic) on type I diabetes during physical activity (hiking, ski touring) at altitude.
- Conditions
- Diet Habit, Type I Diabetes, Activity, Motor, Control
- Trial name
- DIAREAL (NCT06242548)
- Testing
- physical activity outings in the mountains at a level already practised by the subjects, while maintaining their usual diet (normoglucidic or ketogenic)
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Type 1 Diabetes Mellitus
Continuous Glucose Monitoring to Measure Effect of Glycemic Index
Background: Post-prandial hyperglycemia is common in people with type 1 diabetes. Objective: The aim was to determine the impact of low vs high glycemic index (GI) on post-prandial glycemia for breakfast vs lunch and to quantify…
- Trial name
- NCT01145547
- Testing
- Dexcom Seven® Plus Continuous Glucose Monitoring sensor
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Type1diabetes
IN Insulin in Type 1 Diabetes (T1D) Hypoglycemia Unawareness: Safety Only Phase
The purpose of this study is to determine how Humulin-R regular insulin affects the body's ability to feel low blood sugar (hypoglycemia) when delivered intranasally compared to placebo in subjects with Type 1 Diabetes (T1D) with…
- Trial name
- NCT04028960
- Testing
- Regular insulin (Humulin-R), intranasal route, SipNose intranasal device
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Type 1 Diabetes
Closed-Loop Glucagon Administration For Hypoglycemia Treatment
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers glucagon only can prevent or treat hypoglycemia vs. usual care for people with type 1 diabetes > 21 years old.
- Trial name
- NCT02181127
- Testing
- Glucagon-only Bionic Pancreas
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes
BeAT1D: Benign Autoimmunity and Type 1 Diabetes
National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.
- Trial name
- BeAT1D (NCT05139784)
- Testing
- Biosampling
- Where
- 17 sites in France
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity, Non-insulin-dependent Diabetes Mellitus
Effects of HBO Therapy on Muscular Insulin Resistence in Type 2 Diabetes
Hyperbaric oxygen therapy (HBO) is applied for several diseases. The effect on insulin sensitivity is yet unknown. Hypothesis: HBO therapy improves insulin sensitivity in patients.
- Trial name
- NCT01472328
- Testing
- HBO therapy, Hyperbaric room air
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Thromboelastography, Coagulation; Fetus or Newborn
Thromboelastographic Profile in Healthy Newborns and Infants of Diabetic Mothers Using TEG6s
Thromboelastography (TEG) is a laboratory technique used to examine the process of clot formation and degradation by measuring and reporting the kinetic changes, the rate of clot formation, clot strength, and clot stability.
- Conditions
- Thromboelastography, Coagulation; Fetus or Newborn, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT04917965
- Testing
- Laboratory clotting studies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Diabetes Mellitus, Type 1, Diabetic Retinopathy
Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM)
There is evidence from a variety of animal studies that choroidal blood flow is under neural control. Recent results in humans indicate that a light/dark transition is associated with a short lasting reduction in choroidal blood…
- Trial name
- NCT00718614
- Testing
- Light will be switched from 0.5µW/cm2/sr to 115µW/cm2/sr.
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes
A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes
This study will be conducted primarily to evaluate the effects of CT-868 on glucose homeostasis in participants with Type 1 Diabetes Mellitus.
- Trial name
- NCT05794581
- Testing
- CT-868, Victoza
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Carmot Therapeutics, Inc.
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Natural History of Autoimmune Diabetes and Its Complications
Background: Diabetes is a disease defined by abnormally high blood sugar (glucose) levels. Glucose is an essential source of energy for the body s cells, but insulin is required to move the glucose into the cells.
- Trial name
- NCT00896610
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type1 Diabetes Mellitus
Comparison of Motor and Sensory Functions of the Hand in Children With Type 1 Diabetes Mellitus and Their Healthy Peers
Type 1 Diabetes Mellitus (T1DM) is a condition where the body cannot produce a hormone called insulin. Although it is commonly seen in children and young people, it can occur at any age.
- Trial name
- NCT06206317
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Erdal AYDIN
Type 1 Diabetes
An ACT Based Application for Young People With Type 1 Diabetes
Study Objectives: This study aims to assess the feasibility and acceptability of an application utilising Acceptance and Commitment Therapy in young people with type 1 diabetes.
- Trial name
- ACT (NCT02526069)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh