Clinical trials: T1D, open to volunteers
Diabetes Mellitus, Diabetes Mellitus, Type 1
Genetic Risk Score of Type 1 Diabetes Mellitus for Progression to Insulin in Diabetic Patients Lack of Predictive Value: a Multicenter Nested Case-control Study
The goal of this observational study is to evaluate the predictive value of the genetic risk score for type 1 diabetes in the progression to insulin deficiency in diabetic patients. The main question it aims to answer is: 1.
- Trial name
- NCT07621445
- Where
- China
- Volunteers
- 2,950 people
- Sponsor
- Second Xiangya Hospital of Central South University
T1DM - Type 1 Diabetes Mellitus
Allogeneic Anti-CD7 CAR-T for Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by autoimmune destruction of pancreatic beta cells, leading to absolute insulin deficiency and lifelong dependence on exogenous insulin.
- Trial name
- NCT07528105
- Testing
- Allogeneic CD7-Targeted CAR-T Cell Injection
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Type 1
Anti-viral Action Against Type 1 Diabetes Autoimmunity
The study GPPAD-05 AVAnT1A is a phase 4 clinical trial intending to enroll 2252 children, who will be randomly assigned to receive COVID-19 vaccination (Comirnaty® 3 μg Omicron XBB.1.5 or new variant Comirnaty vaccines ) or…
- Trial name
- NCT06452654
- Testing
- Comirnaty Injectable Product, Sodium Chloride 0.9% Inj
- Where
- 9 sites in Austria, Belgium and 3 more
- Volunteers
- 2,252 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Type 1 Diabetes
Intervention for Children With Type 1 Diabetes Targeting Gut Microbes
The goal of this clinical study is to evaluate the effect of nutritional intervention program based on dietary products in the clinical treatment of newly diagnosed children with type 1 diabetes.
- Trial name
- TRIM1 (NCT06198725)
- Testing
- Trimtab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Children's Hospital of Fudan University
Stem Cells, Type 1 Diabetes
Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes
Type 1 Diabetes is a chronic autoimmune disease. It results from autoimmune destruction of pancreatic Beta cells leading to absolute insulin insufficiency.
- Trial name
- NCT06951074
- Testing
- Insulin producing stem cells infusion
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
Basic Hematological Parameters and Coagulation Profile in Type 1 Diabetic Children
Diabetes mellitus is a group of chronic metabolic diseases characterized by hyperglycemia .Type 1 diabetes is a heterogeneous disease related to the destruction of pancreatic beta cells and is a result of absolute lack of insulin…
- Trial name
- NCT06897904
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Lung Adenocarcinoma
PHOENIX: QL1706 Plus Chemotherapy and Bevacizumab in AGA-Resistant, PD-L1 ≥50% Non-Squamous NSCLC
The goal of this Phase II clinical trial (The PHOENIX Study) is to evaluate if the combination of QL1706 (Iparomlimab and Tuvonralimab), bevacizumab, and chemotherapy can treat patients with TKI-refractory, driver-gene positive…
- Trial name
- PHOENIX (NCT07416058)
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CLTA-4)
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Guangdong Association of Clinical Trials
Diabetes Mellitus, Type 1, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity
The main purpose of this study is to learn more how tirzepatide affects stomach emptying in participants with Type 1 Diabetes Mellitus (T1DM) and overweight or obesity.
- Conditions
- Diabetes Mellitus, Type 1, Overweight, Obesity
- Trial name
- NCT07803744
- Testing
- Tirzepatide, Acetaminophen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eli Lilly and Company
Diabetes Type 1
Insul-In This Together: Leveraging Family Support and Diabetes Technology for Adolescents Living With Type 1 Diabetes
The goal of this clinical trial is to learn if the "Insul-In This Together" family program works to improve outcomes for adolescents living with type 1 diabetes.
- Trial name
- IITT (NCT07856836)
- Testing
- Insul-In This Together
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Diabetes Mellitus Type 1, Healthy Ageing
FinnDiane LifeOne Study - Impact of Ageing on People With Type 1 Diabetes
Healthy aging refers to functional ability that enables well-being in older individuals. The focus thus shifts from chronological age to functional capacity and the individual's own experience of well-being.
- Trial name
- LifeOne (NCT07289204)
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Type 1 Diabetes
Screening For Social Determinants Of Health In Routine Diabetes Care
Social determinants of health (SDOH) exert a powerful influence on the everyday management of type 1 diabetes (T1D) and short and long term outcomes of T1D.
- Trial name
- SDOH (NCT07706803)
- Testing
- Social Determinants of Health (SDOH) Screening and Referral
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Type 1 Diabetes
Cohort Study of Patients With Type 1 Diabetes Registered With Mobile Application in China
For last decade, the innovation of mobile health platform has brought new opportunities for disease management. Previous studies have shown that health management programs based on mobile platforms for patients with diabetes can…
- Trial name
- COOPERATIONS (NCT05163054)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking University Third Hospital
Type 1 Diabetes
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).
- Trial name
- SAFEGUARD (NCT07187531)
- Testing
- High Dose SAB-142, Low Dose SAB-142
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 159 people
- Sponsor
- SAb Biotherapeutics, Inc.
Diabetes Mellitus Type 2, Diabetes Mellitus Type 1, NAFLD - Nonalcoholic Fatty Liver Disease
Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program
Kuwait and the Gulf Region lack large longitudinal studies that identify risk factors dictating the onset of prediabetes and the progression to diabetes.
- Conditions
- Diabetes Mellitus Type 2, Diabetes Mellitus Type 1, NAFLD - Nonalcoholic Fatty Liver Disease, PreDiabetes
- Trial name
- KADEM (NCT06115876)
- Where
- Kuwait
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Dasman Diabetes Institute
Type 1 Diabetes
Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D).
- Trial name
- NCT06455319
- Testing
- Anti-thymocyte globulin (ATG), verapamil extended release capsule
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Diabetes Mellitus, Type 2, Food Insecurity
Food Insecurity Reduction & Strategy Team
This study seeks to address the multifaceted challenges posed by food disparities and their negative consequences on health outcomes, via a comprehensive community health intervention program. Study objectives include: 1.
- Conditions
- Diabetes Mellitus, Type 2, Food Insecurity, Diabetes Mellitus, Type 1
- Trial name
- FIRST (NCT06329375)
- Testing
- Nutrition program
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Stanford University
Diabetes Mellitus, Type 1
Starting Technology in At Risk Type 1 Diabetes Study
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c>8.5%).
- Trial name
- STAR-T1D (NCT06453928)
- Testing
- Hybrid Closed Loop Insulin Pump System
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Type I Diabetes
Clinical Evaluation of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in Adult Subjects With Type 1 Diabetes (CIP347)
The purpose of this study is to evaluate the clinical performance of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in adult patients with Type 1 diabetes mellitus that cannot be controlled with subcutaneous insulin…
- Trial name
- Phoenix CIP347 (NCT06739811)
- Testing
- Implantable Insulin Pump System
- Where
- 11 sites in France, Netherlands
- Volunteers
- 40 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes (T1D), Type 2 Diabetes
Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery
The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care…
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- PREPARE 4 AID (NCT07011147)
- Testing
- Bionic Pancreas, Routine Care
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes (T1D)
Feasibility Study of a Continuous Glucose-Ketone Monitoring Device in People With Type 1 Diabetes
The goal of this study is to evaluate a CGM-CKM device during insulin suspension in patients with type 1 diabetes. 10 patients with T1D will be recruited for a pilot study. The patients will visit CTRU at Stanford Medical School.
- Trial name
- NCT06977633
- Testing
- Temporary Insulin Suspension, Glucose and ketone sensor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mahla Poudineh