Clinical trials: T2D
Diabetes Mellitus, Type 2
A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People
In this study, participants will receive semaglutide and NNC0480-0389 together at the same time. Semaglutide is a medicine that can already be prescribed, whereas NNC0480-0389 is a new potential medicine.
- Trial name
- NCT05046873
- Testing
- Co-formulation NNC0480 0389+Semaglutide A 10/1 mg/mL, Semaglutide 1.34 mg/mL, NNC0480-0389 A 10 mg/mL
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy, Type 2 Diabetes
Forearm Immobilization in T2D
The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with…
- Trial name
- FIT2D (NCT06750497)
- Testing
- Forearm immobilization
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Diabetes, Prediabetes
The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk
The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because…
- Trial name
- NCT01972542
- Testing
- Oral fat tolerance test
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Type2 Diabetes Mellitus, Cardiovascular Diseases
Mil Familias-Santa Barbara's Operational Pilot to Understand Diabetes in the Latino Community
The Mil Familias Program is a 10-year initiative to reduce the burden of cardio-metabolic disease among Latino families in the Central Coast of California.
- Trial name
- MilFamilias (NCT03736486)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
A Study to Demonstrate Pharmacokinetic and Pharmacodynamic Biosimilarity Between HEC-Glargine and US-Lantus® in Healthy Male Volunteers
This is a phase 1 study to demonstrate pharmacokinetic and pharmacodynamic similarity between HEC-Glargine and US-Lantus® using the euglycemic clamp technique in healthy male adult volunteers.
- Trial name
- NCT05248841
- Testing
- HEC-Glargine, US-Lantus
- Where
- South Africa
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Obesity, Diabetes Mellitus, Type 2
Stage-based Exercise Promotion Study
The purpose of this study is to increase regular physical activity among students by fostering self-management competencies. The intervention was implemented as paper-pencil intervention.
- Trial name
- STEPS (NCT01289145)
- Testing
- Motivational intervention, Volitional intervention, Active Control
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Freie Universität Berlin
Diabetes Mellitus, Type 2, Coronary Artery Disease
Optimizing Audit and Feedback for Primary Care
There remains a large gap between ideal and actual care provided to patients with chronic diseases. Performance feedback reports are often used as a foundation for quality improvement interventions.
- Trial name
- NCT00996645
- Testing
- Worksheet to facilitate goal-setting and action plans
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetes Mellitus Type 2, Heart Failure
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with…
- Conditions
- Diabetes Mellitus Type 2, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT06774014
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Type 2 Diabetes
Clinical Study to Evaluate the Pharmacokinetics and Safety of CKD-383 0.5/10/1000mg in Healthy Volunteers
This study is a randomized, open-label, single dose, crossover study to evaluate the pharmacokinetics and safety of CKD-383 in healthy volunteers.
- Trial name
- NCT07304700
- Testing
- CKD-383 0.5/10/1000mg, CKD-501, D744, D150
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Diabetes
Evaluation of a Nutritional Supplement for People With Type 2 Diabetes.
The objective of this trial is to evaluate a nutritional supplement for people with Diabetes.
- Trial name
- NCT01850134
- Testing
- Experimental Study Product, Control Study Product
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Diabetes Mellitus, Type 2, Hydroxymethylglutaryl-CoA Reductase Inhibitors
The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion
The primary objective of the present study is to evaluate the effect of HMG-CoA reductase inhibition during 14 days on the postprandial plasma GLP-1 response in healthy individuals.
- Trial name
- NCT03018444
- Testing
- Atorvastatin
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese
Implementation of a Peer Leader-facilitated Dyadic Intervention
This Pilot Study Large Application builds upon the results of our prior work to 1) Implement and pilot test a peer leader-facilitated 12-week dyadic intervention (Community Health among Asian Indian immigrants (CHAI) Dyad study)…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese, Hyperlipidemias
- Trial name
- NCT06643806
- Testing
- CHAI dyad study
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Type 2 Diabetes Mellitus
A Study of MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)
This is a study to assess the pharmacokinetics, safety, and tolerability of sequential single oral doses of MK-8093 10 mg, 40 mg, 200 mg, or placebo to MK-8093 (Part 1) depending on treatment assignment in young healthy male…
- Trial name
- NCT02012166
- Testing
- MK-0893 10 mg, MK-0893 40 mg, MK-0893 200 mg
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
A Phase 1 Study of Ertugliflozin in Healthy Male Participants (MK-8835-020)
This study will evaluate the absolute oral bioavailability (F) and fraction absorbed (Fa) of ertugliflozin following oral administration of unlabeled ertugliflozin (MK-8835) and intravenous (IV) and oral administration of…
- Trial name
- NCT02411929
- Testing
- Unlabeled ertugliflozin for oral use, 14^C-labeled ertugliflozin for IV use, 14^C-labeled ertugliflozin for oral use
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2
Relationship Between Improvement in Insulin Secretion and Decrease in HbA1c in GLP-1 RA Therapy in T2DM Patients
GLP-1 receptor agonists (GLP-1 RA) is group of antidiabetic agents very effective in lowering the plasma glucose concentration in T2DM patients .
- Trial name
- NCT04135287
- Testing
- GLP-1 receptor agonist
- Where
- Kuwait
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Dasman Diabetes Institute
Type 2 Diabetes, Insulin Resistance
Nesfatin-1 Level in Patients With Type 2 Diabetes, Insulin Resistance and Obesity
This research was planned to determine the level of nesfatin-1, known as satiety hormone, in type 2 diabetes, insulin diabetes and obesity patients and to determine whether there is a relationship between patients' energy intake…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity, Nesfatin-1
- Trial name
- NCT04298515
- Testing
- Nesfatin-1
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Type2 Diabetes, Fatty Liver, Nonalcoholic
Mechanism of Serum PRL in the Development of MAFLD
Metabolic associated fatty liver disease (MAFLD) has currently reached a worldwide epidemic. Serum PRL levels within or outside physiological range have been found to affect metabolic homeostasis differently.
- Conditions
- Type2 Diabetes, Fatty Liver, Nonalcoholic, Liver Fibrosis
- Trial name
- NCT05525884
- Testing
- non-invasive method, Fibroscan
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shen Qu
Insulin Resistance, Low Birth Weight
Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight
Chronic stress has been proposed to be involved the development of western life-style diseases such as cardiovascular disease and type 2 diabetes (T2DM).
- Conditions
- Insulin Resistance, Low Birth Weight, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- LBW-SSRI (NCT00971815)
- Testing
- Escitalopram
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus, Bone Remodeling
Changes in Bone Turnover With Exposure to a GLP-1 Receptor Agonist
The purpose of this study is to determine changes in bone turnover markers and calcitonin following the initiation of exenatide compared to placebo in postmenopausal women wtih type 2 diabetes.
- Trial name
- CMBD (NCT01381926)
- Testing
- exenatide, Saline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Overweight, Obese
UCSD Take Charge Study
The purpose of the Take Charge Study is to determine among overweight and obese men and women with type 2 diabetes whether 1) participating in a commercial weight loss program promotes great weight loss and weight loss…
- Conditions
- Overweight, Obese, Obesity, Diabetic
- Trial name
- NCT01345500
- Testing
- Higher Carbohydrate, Lower Fat Diet, Lower carbohydrate, Higher fat diet, Individualized Counseling
- Where
- 2 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
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