Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Type 2 Diabetes Mellitus (T2DM)
Clinical Study to Evaluate the Food Effect of CKD-383 0.5/10/1000mg in Healthy Volunteers
This study is a randomized, open-label, single dose, crossover study to evaluate the food effect of CKD-383 in healthy volunteers
- Trial name
- CKD-383 FDI P1 (NCT06695572)
- Testing
- CKD-383
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Diabetes Mellitus, Type 2
Self Titration With Apidra to Reach Target Study (START)
Primary Objective: The primary objective of this study is to demonstrate non-inferiority of a patient-managed titration algorithm (including blood glucose monitoring) for the addition of a single dose of insulin glulisine at…
- Trial name
- NCT01013571
- Testing
- insulin glargine, Apidra (insulin glulisine)
- Where
- Canada
- Volunteers
- 493 people
- Sponsor
- Sanofi
Diabetic Patients,Self-Care,Artificial Intelligence-Based,Self-Efficacy, Type 2 Diabetes Mellitus (T2DM)
Diabetic Patients,Self-Efficacy,Self-Care Behaviors,Artificial Intelligence-Based
This study employed an experimental research design using a randomized controlled trial methodology. Group allocation was performed randomly by generating serial numbers through a computer.
- Trial name
- NCT06985680
- Testing
- LINE@ Diabetes Health Education Chatbot
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chia-Tzu Line
Type 2 Diabetes Mellitus (T2DM), Diabetes Self-management
Technology-Based Education and Follow-Up in Type 2 Diabetes Management
This study aims to evaluate whether a nurse-led, technology-based education and follow-up program can improve diabetes management in individuals with type 2 diabetes. Participants were randomly assigned to two groups.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Diabetes Self-management, Glycemic Control
- Trial name
- PAS-DM (NCT07513961)
- Testing
- Technology-Based Diabetes Education and Follow-up System (PAS-DM)
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Alanya Alaaddin Keykubat University
Obesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus
Fat Around Heart Arteries as a Measure of Inflammation in Patients With Glycometabolic Disease
In this study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart.
- Conditions
- Obesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus, Type 2 Diabetes (T2DM), Prediabetes
- Trial name
- PCAT-GMD (NCT07144670)
- Where
- Denmark
- Volunteers
- 747 people
- Sponsor
- Odense University Hospital
Type 2 Diabetes Mellitus
Comparative Study of HOE490 O (Glimepiride and Metformin) Compared With Placebo on Top of Glimepiride
Primary objective of this study is to confirm the efficacy of HOE490 O (glimepiride/metformin) compared with placebo on top of glimepiride in HbA1c change.
- Trial name
- NCT00924573
- Testing
- Metformin, Glimepiride (HOE490)
- Where
- Japan
- Volunteers
- 189 people
- Sponsor
- Sanofi
Type 2 Diabetes (T2DM)
Investigation of the Effect of Intrinsic Foot Muscle Training on Plantar Pressure Distribution in Individuals With Type 2 Diabetes Mellitus
The goal of this experimental randomized controlled study is to evaluate the effectiveness of the exercise program to be applied to prevent foot wounds, which is one of the leading foot problems that develop as a result of…
- Trial name
- NCT05974020
- Testing
- Control, Intrinsic Muscle Training, Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Type-2 Diabetes Mellitus
A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study)
The purpose of this study is to assess the safety, tolerability and effectiveness of RF vapor ablation of the proximal intestinal mucosa.
- Trial name
- RESTORE-1 (NCT07355270)
- Testing
- RF Vapor Ablation
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aqua Medical, Inc.
Diabetes Mellitus, Type 2, Antioxidative Stress
Dietary Antioxidants and Thiol Disulfide Homeostasis in T2DM
This observational study was planned to determine the relationship between dietary antioxidant intake and thiol disulfide homeostasis of individuals with type 2 diabetes.
- Trial name
- NCT05688631
- Testing
- Dietary antioxidant intake
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Type 2 Diabetes Mellitus, Susceptibility, Genetic
Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM
This is a retrospective cohort study of patients with T2DM who were treated with exenatide twice daily as a part of their diabetes care for at least 12 months.
- Trial name
- NCT06256419
- Testing
- GLP-1 receptor agonist, responders group and nonresponders group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Diabetes Mellitus, Type 2
OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)
The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes.
- Trial name
- OASIS (NCT06003634)
- Testing
- Peer Coaching - Peer Participants A, Peer Coaching - Peer Participants B, Peer Coaching - Peer Participants C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 2 Diabetes Mellitus (T2DM)
Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of CT-L03 in Healthy Volunteers
This is a randomized, open, single-dose, crossover-design, phase I study to evaluate the pharmacokinetics and safety after co-administration of L03RD1 and L03RD2 or administration of CT-L03 in healthy volunteers.
- Trial name
- NCT07158346
- Testing
- L03RD1, L03RD2, CT-L03
- Where
- South Korea
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Celltrion
Type 2 Diabetes Mellitus (T2DM), Self-management
Effects of a Researcher-Designed Diabetes Self-Management App on Self-Management Obstacles, Self-Efficacy, and Physiological Indicators in Type 2 Diabetes
This study aims to evaluate the effectiveness of a self-developed diabetes self-management mobile application on disease self-management outcomes among individuals with type 2 diabetes.
- Trial name
- Application (NCT07794384)
- Testing
- Researcher-Designed Diabetes Self-Management Application
- Volunteers
- 80 people
- Sponsor
- Fu Jen Catholic University Hospital
Type 2 Diabetes Mellitus With Circulatory Complciation
Neurotronic Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities
The study is to assess the safety and feasibility of chemical denervation of multiple artery beds for the treatment of Type 2 diabetes (T2DM) and its comorbidities.
- Trial name
- NECTAR (NCT04232774)
- Testing
- The Neurotronic arterial ablation catheter
- Where
- Paraguay
- Volunteers
- 22 people
- Sponsor
- Neurotronic, Inc.
Diabetes Mellitus, Type 2, Prediabetic State
PREDICT-DM: Community Pharmacy-Based Point-of-Care Testing for Undiagnosed T2DM
The goal of this observational study is to learn whether community pharmacy-based risk assessment and point-of-care HbA1c testing can help detect undiagnosed type 2 diabetes and prediabetes among adults in Irbid Governorate…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Prediabetes / Type 2 Diabetes, T2DM
- Trial name
- PREDICT-DM (NCT07795918)
- Where
- Jordan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Type 2 Diabetes Mellitus (T2DM)
Health Literacy in Patients With Type 2 Diabetes Mellitus.
The primary objective of this pragmatic trial was to analyze the effectiveness of health literacy in patients with type 2 Diabetes mellitus (DM2) on a protocol of care in Primary Health Care (PHC) units.
- Trial name
- NCT07045662
- Testing
- Multidisciplinary Assessment
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Ernanda Mezaroba
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCl 25 mg/5 mg/1000 mg Extended Release Tablet Versus Trijardy® XR 25 mg/5 mg/1000 mg Extended- Release Tablets
An open label, randomized, two-period, two treatment, two-sequence, crossover, balanced, single dose oral bioequivalence study to compare Empagliflozin/ Linagliptin/ Metformin HCl 25 mg/5 mg/1000 mg Extended Release Tablet versus…
- Trial name
- NCT07691203
- Testing
- Empagliflozin/Linagliptin/Metformin HCl Extended Release Tablet, Trijardy® XR Tablets
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Type 2 Diabetes (T2DM)
Pancreatin Added to Standard Antihyperglycemic Therapy in Patients With Type 2 Diabetes
Medications that enhance the incretin effect (GLP-1 receptor agonists, tirzepatide (GIP/GLP-1 receptor agonist) and DPP-4 inhibitors) are used in treatment of patients with type 2 diabetes.
- Trial name
- NCT07852988
- Testing
- Pancreatin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Silesian Centre for Heart Diseases
Diabete Mellitus, Type 2 Diabetes
Mangosteen Supplement as Adjuvant Therapy With Sitagliptin/Metformin in Iraqi Patients With Type 2 Diabetes
This clinical trial was conducted at the National Diabetes Center for Treatment and Research, Mustansiriyah University, Baghdad (Sept 2024-May 2025).
- Conditions
- Diabete Mellitus, Type 2 Diabetes, Obesity Type 2 Diabetes Mellitus, Dyslipidemia in Patients With Diabetes Mellitus
- Trial name
- NCT07172269
- Testing
- Sitagliptin + Metformin, mangosteen supplement, Lifestyle Management
- Where
- Iraq
- Volunteers
- 58 people
- Sponsor
- Mais Qais Hbeeb
Type2 Diabetes Mellitus
A Phase 2 Study of DS-8500a in Japanese Subjects With Type 2 Diabetes Mellitus (T2DM)
The objectives of the study is to evaluate the efficacy, safety, and dose of DS-8500a compared with placebo in patients with type 2 diabetes mellitus.
- Trial name
- NCT02628392
- Testing
- DS-8500a, Sitagliptin
- Where
- Japan
- Volunteers
- 368 people
- Sponsor
- Daiichi Sankyo Co., Ltd.