Clinical trials: TBI (Traumatic Brain Injury)
Traumatic Brain Injury, Post Traumatic Stress Disorder
A Study of Brain Aging in Vietnam War Veterans
Traumatic brain injury (TBI) and post traumatic stress disorder (PTSD) are common combat related problems and may be associated with a greater risk of Alzheimer's disease (AD).
- Conditions
- Traumatic Brain Injury, Post Traumatic Stress Disorder, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- DOD-ADNI (NCT01687153)
- Where
- 19 sites in United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Traumatic Brain Injury, Post-concussive Headaches
Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI)
The specific aims of the proposed study are to evaluate: 1) the feasibility of design elements of a Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI) intervention trial (e.g., an exercise…
- Trial name
- SAA-TBI (NCT03277859)
- Testing
- SAA-TBI
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- VA Eastern Colorado Health Care System
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Traumatic Brain Injury, Dementia
Amyloid Accumulation After Mild Traumatic Brain Injury
We are extending the researches of Taiwan neurosurgery traumatic brain injury (TBI) database which is led by Professor WT Chiu in Taipei Medical University and will recruit mild TBI (mTBI) participants who have ever been…
- Conditions
- Traumatic Brain Injury, Dementia, Alzheimer Disease
- Trial name
- TBI (NCT02134041)
- Testing
- traumatic brain injury
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury, Trauma, Head
Complement Inhibition: Attacking the Overshooting Inflammation @Fter Traumatic Brain Injury
Severe Traumatic Brain Injury (s-TBI) is a major cause of death and disability across all ages. Besides the primary impact, the pathophysiologic process of major secondary brain damage consists of a neuroinflammation response…
- Trial name
- CIAO@TBI (NCT04489160)
- Testing
- C1 Inhibitor, Human
- Where
- 3 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Leiden University Medical Center
Mild Head Injury, Anticoagulant
Medico-economic Interest of the Protein S100b in Mild Head Trauma Under Anti-thrombotics
Head trauma is a common injury in emergency department. Investigation to search for complication is guided by the clinical examination and the case history, such as taking anti-thrombotics.
- Conditions
- Mild Head Injury, Anticoagulant, Antiplatelet
- Trial name
- ISTCAT (NCT04305821)
- Testing
- Dosage of S100β protein
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Rennes University Hospital
Vegetative State, Stroke
Navigated Brain Stimulation in Diagnosis of Minimally Conscious State
It has already been demonstrated that mental imagining of the complex motor act, such as limb lifting, can evoke the activation of the involved motor centres even if it doesn't result in movement due to paresis.
- Conditions
- Vegetative State, Stroke, Brain Injury
- Trial name
- C-fMRI-NBS (NCT01467908)
- Testing
- Navigated transcranial magnetic brain stimulation
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- Clinical Institute of the Brain, Russia
Traumatic Brain Injury, Controls
Traumatic Brain Injury Feasibility Study (EPIC-011)
The purpose of this research study is to evaluate whether data made by the ClearView System can be used to detect whether someone has a traumatic brain injury and how severe the injury is.
- Trial name
- TBI (NCT02471625)
- Testing
- ClearView Scanning
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Caregiver Burden, Caregiver Stress Syndrome
Traumatic Brain Injury and Alzheimer's Disease/Related Dementias Caregiver Support Intervention
The TBI-AD/ADRD Caregiver Support Intervention (TACSI) incorporates psychosocial and psychoeducational approaches with the objective of: a) identifying stressors associated with caregiving for family members who have the dual…
- Conditions
- Caregiver Burden, Caregiver Stress Syndrome, Caregiver Burnout
- Trial name
- TACSI (NCT05465109)
- Testing
- TBI-AD/ADRD Caregiver Support Intervention (TACSI)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071949
- Testing
- Adezunap
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Concussion, Mild, Traumatic Brain Injury
Improving In-hospital and Post-discharge Patient Education for Mild Traumatic Brain Injury
The purpose of this study is to develop and validate ways to provide better patient education and clinical management for individuals who go to the emergency department (ED) with concussion or mild traumatic brain injury (mTBI).
- Trial name
- EDucate (NCT06595914)
- Testing
- Clinical implementation strategies
- Where
- United States
- Volunteers
- 5,831 people
- Sponsor
- Medical College of Wisconsin
Traumatic Brain Injury, Caregiver Burden
m-Health Supportive Care Transition Program in Improving Post-Discharged Outcomes
This intervention study aims to investigate the effects of the m-Health supportive care transition program on response patterns (transition stress and the burden of caregiving) among traumatic brain injury (TBI) caregivers and…
- Conditions
- Traumatic Brain Injury, Caregiver Burden, Stress
- Trial name
- NCT05951335
- Testing
- m-Health Transition Care Program
- Where
- Thailand
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Concussion; Syndrome
Correlation Between Changes in Measures of the Visual System and Changes in Concussion-associated Symptoms
Sports-related concussion affect 1.6 to 3.8 million people each year in the United States. Despite increased media attention and awareness campaigns, the exact number is difficult to determine due to underreporting by athletes.
- Trial name
- NCT03259178
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McGill University
Traumatic Brain Injury
Magnetic Resonance Elastography in Patients With Acute Closed Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public health issue, and intracranial hypertension in the acute phase remains a critical scientific issue.
- Trial name
- NCT04361578
- Testing
- Magnetic resonance elastography
- Volunteers
- 43 people
- Sponsor
- Xiangya Hospital of Central South University
Traumatic Brain Injury, Attention Deficit Disorder
Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits
The purpose of this research study is to evaluate whether Vyvanse, a psychostimulant, can help with attention deficits due to traumatic brain injury (TBI).
- Trial name
- NCT01000064
- Testing
- Vyvanse, fMRI
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University
Traumatic Brain Injury
Non-Interventional F-Two Isoprostane Trial (NIFTI)
Each year in the United States alone, 300,000 persons are hospitalized for traumatic brain injury, with approximately one quarter dying.
- Trial name
- NIFTI (NCT00505908)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
This study will evaluate the effects of TT301 on cytokine levels in healthy male volunteers participating in an endotoxin challenge.
- Trial name
- NCT01357421
- Testing
- TT301
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Urinary Tract Infection, Head Injury
Video Discharge Instructions (VDI) as Adjuncts to Written Discharge Instructions in the Emergency Department
Patients seen in the ED with either a laceration, minor head injury, or urinary tract infection will be randomized to one of two groups.
- Conditions
- Urinary Tract Infection, Head Injury, Laceration
- Trial name
- NCT02882256
- Testing
- Video discharge instructions
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- George Washington University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and…
- Trial name
- Keppra (NCT00618436)
- Testing
- Levetiracetam, Phenytoin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Cincinnati