Clinical trials: TKA, active
Obesity, Osteoarthritis
Attune With TruMatch TM Personalized Solutions Instruments
The purpose of our study is to determine, using a prospective, randomized-controlled trial, the economic viability and clinical outcomes associated with patient-specific instrumentation (PSI) for total knee arthroplasty in an…
- Trial name
- NCT02177227
- Testing
- Attune TruMatch (TM) Patient-Specific Instrumentation
- Where
- Canada
- Volunteers
- 194 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Primary Total Knee Arthroplasty
Journey Bicruciate Stabilized (BCS) Design and Legion Posterior Stabilized (PS) Design; Comparative Study
Today, primary total knee arthroplasty (TKA) is considered to be a safe and successful therapy for end-stage osteoarthritis of the knee.
- Trial name
- BCR (NCT04855864)
- Testing
- Follow-up of BCR TKA, Follow-up of BCS TKA, Follow-up of PS TKA
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Knee Arthropathy, Arthroplasty Complications
l Investigation of Robotic-assisted TKA (RA-TKA) With Skywalker and Evolution Medial Pivot Knee (eMP Knee)
This is a prospective trial that attempts to develop evidence on the safety and performance of RA-TKA (Robotic-assisted total knee arthroplasty) with Skywalker and eMP (Evolution Medial Pivot) knee.
- Conditions
- Knee Arthropathy, Arthroplasty Complications, Robotic Assisted Arthroplasty, TKA Outcomes
- Trial name
- NCT06969222
- Testing
- Robotic TKA, Conventional TKA
- Where
- Greece
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Department of General University Hospital of Laria
Infection
Infection Prevention After TKA With or Without Vancomycin
Prospective, Randomized, Double Blinded Trial Comparing Clinical, Radiological and Laboratory Outcomes in prevention of infection after Total Knee Arthroplasty With or Without Vancomycin.
- Trial name
- TKA_Vanco (NCT05461651)
- Testing
- Knee arthroplasty
- Where
- Poland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Total Knee Anthroplasty, Postoperative Pain
Proximal Spread in Adductor Canal Block(ACB)
This prospective, randomized clinical study is designed to evaluate the effects of two different injection levels of adductor canal block (ACB) on the proximal spread of local anesthetic and clinical outcomes in patients…
- Trial name
- ACB (NCT07595471)
- Testing
- Comparison of Proximal Adductor Canal Block, Comparison True Distal Adductor Canal Block.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara Etlik City Hospital
Total Knee Arthroplasty
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at…
- Trial name
- NCT06640491
- Testing
- IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Post Operative Pain
Methadone in TKA for Post-op Pain and Opioid Reduction
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total…
- Trial name
- NCT07226076
- Testing
- Methadone Hydrochloride
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Medical University of South Carolina
Total Knee Replacement
Femoral Component TKA: Extramedullary vs Conventional Intramedullary Guide
The study wants to evaluate the performance of this EM guide in comparison to a traditional IM guide. 75 patients will be included in the extramedullary group (to be compared with a corresponding previous group of 75 patients…
- Trial name
- EMAX (L2055) (NCT07815080)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
PONV
Aprepitant to Improve Same Day Discharge for TKA
The purpose of this research is to study whether adding an FDA approved medication called aprepitant (a medication given to patients like you to reduce or eliminate nausea and vomiting) to the usual treatment to prevent nausea…
- Trial name
- NCT07639723
- Testing
- Aprepitant Injection, Ondansetron (Zofran), Dexamethasone
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Endeavor Health
Elective Primary THA or TKA
Is Routine Dental Clearance or Antibiotic Prophylaxis Before Dental Procedures Necessary in Total Joint Arthroplasty? A Randomized Controlled Noninferiority Trial
This study is a prospective, randomized, controlled, noninferiority trial with parallel assignment that will afford simultaneous assessment of the omission of dental clearance and the omission of post-operative antibiotics for…
- Trial name
- NCT07917533
- Testing
- Dental Clearance and Routine Antibiotic Prophylaxis
- Volunteers
- 3,048 people
- Sponsor
- Creighton University
Total Knee Arthroplasty, Knee Osteoarthristis
Application of Perinatal Derivatives in Total Knee Arthroplasty
This pilot study investigators whether the use of perinatal derivatives during knee replacement, in the form of an injection around the joint and patch over the knee joint incision, improves patient outcomes (including…
- Trial name
- NCT07908342
- Testing
- Intraoperative application of CTM Flow and CTM Thick, Total knee arthroplasty (TKA)
- Volunteers
- 48 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteo Arthritis Knee
Tibial and Femoral Components Migration and Adaptive Bone Remodeling After Insertion of Persona® TKA
The purpose of this study: In a prospective randomized study with 2 years of follow-up we want to compare the migration of the uncemented trabecular metal (TM) versus the cemented tibial and femoral components of the new Persona®…
- Trial name
- NCT03563131
- Testing
- Persona® total knee arthroplasty
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Hip Arthroplasty (THA), Total Knee Arthroplasty (TKA)
Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty
The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative…
- Conditions
- Total Hip Arthroplasty (THA), Total Knee Arthroplasty (TKA), Hip Osteoarthritis, Knee Osteoarthristis
- Trial name
- NCT07347821
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Warsaw
Arthropathy of Knee
A Comparison Of Primary TKA Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy
This will be a prospective, randomized, noninferiority clinical trial comparing rehabilitation methods post-total knee arthroplasty (TKA).
- Trial name
- NCT04924205
- Testing
- FM2 Knee Brace
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nicolas Noiseux, MD, MS, FRCSC
Prosthetic-joint Infection
Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty
The goal of this clinical trial is to evaluate whether the investigational drug PLG0206 can help reduce recurrence of infection in adults who have undergone total knee replacement and are receiving a DAIR (Debridement…
- Trial name
- RETAIN (NCT07214311)
- Testing
- PLG0206
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 240 people
- Sponsor
- Peptilogics
Wear of Articular Bearing Surface of Prosthetic Joint, Migration of Implant
Migration of CS vs CR Insert in TKA Using RSA
Background: The choice whether or not to preserve the posterior cruciate ligament (PCL) in total knee arthroplasty (TKA) is coupled to the us of a PCL-retaining (CR) or a condylar (CS) insert.
- Trial name
- CS vs CR RSA (NCT05936593)
- Testing
- Condylar Stabilizing (CS) insert, Cruciate Retaining (CR) insert
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Rehabilitation Exercise
Evaluating the Efficacy of a "Quiet Knee Protocol" in Primary Total Knee Arthroplasty (TKA): A Prospective Randomized Study
The goal of this randomized clinical trial is to access the following: 1. Compare the effectiveness of the QKP versus a standard rehabilitation protocol in improving postoperative pain control, ROM, and functional recovery…
- Trial name
- QKP (NCT07879014)
- Testing
- Quiet Knee Protocol, Post Operative Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Musculoskeletal Disease
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving…
- Conditions
- Knee Osteoarthritis, Musculoskeletal Disease, Surgery
- Trial name
- TKACSI (NCT07151417)
- Testing
- PAI, PAI + steroid, PAI + zilretta
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Walter Reed National Military Medical Center