Clinical trials: Tachyphylaxis
Type 2 Diabetes
The Reduced Insulinotropic Effect of a Continuous Infusion Relative to a Bolus Injection of GIP
In patients with type 2 diabetes, the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has lost its insulinotropic activity, but more so after continuous versus bolus administration.
- Trial name
- NCT02673554
- Testing
- GIP Bolus, GIP Clamp, Oral glucose tolerance test (OGTT)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Diabeteszentrum Bad Lauterberg im Harz
Allergic Rhinitis, Tachyphylaxis
Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation
The investigators wish to evaluate the onset of tolerance to nasal decongestants like oxymetazoline (available over the counter) and the mechanism of tolerance particularly with differential effects on alpha 1 and alpha 2…
- Conditions
- Allergic Rhinitis, Tachyphylaxis, Rhinitis Medicamentosa
- Trial name
- NCT00487032
- Testing
- Oxymetazoline 0.05% w/v, Fluticasone propionate 50 micrograms per actuation, Prazosin hydrochloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brian J Lipworth