Clinical trials: Target Controlled Infusion
Anti-bacterial Agents, Pharmacokinetics
The Expected Advantage of Administering Prophylactic Antibiotics Using Target- Concentration Controlled Infusion
Preoperative antimicrobial prophylaxis is a key element for the prevention of surgical site infection, the most common type of nosocomial infection in surgical patients.
- Conditions
- Anti-bacterial Agents, Pharmacokinetics, General Surgery
- Trial name
- NCT05253339
- Testing
- target-controlled infusion (one of the administration methods), Standard administration method
- Where
- South Korea
- Volunteers
- 2,494 people
- Sponsor
- Asan Medical Center
Anesthesia
Dexmedetomidine and Desflurane Consumption
The aim of this study is to calculate desflurane consumption when combined with intraoperative dexmedetomidine infusion guided by bispectral index (BIS)
- Trial name
- NCT02652312
- Testing
- Dexmedetomidine, Ondansetron, fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Pain
Remifentanil Versus Propofol for TCI Sedation of Patients Undergoing Gastrointestinal Endoscopic Procedures
The purpose of this study was to compare remifentanil and propofol for sedation of patients during endoscopic gastrointestinal procedures.
- Trial name
- NCT01746641
- Testing
- Remifentanil, Propofol
- Where
- Colombia
- Volunteers
- 69 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Anesthesia
Bispectral Index Under Propofol Anesthesia in Children : a Study Between TIVA and TCI
In children, only a few studies have compared different modes of propofol infusion during a total intravenous anesthesia (TIVA) with propofol and remifentanil.
- Trial name
- NCT02637726
- Testing
- Propofol : TCI Schnider, Propofol : TCI Kataria, Propofol : TIVA
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Pr Isabelle CONSTANT
Patient-controlled Sedation
Patient-controlled Sedation Versus Target-controlled Infusion in Orthopaedic Surgery Under Central Neuraxial Block
Orthopaedic surgeries involving the legs can be done under nerve block, where patients will be numb of pain at the operated site but awake during surgery.
- Trial name
- NCT03647735
- Testing
- patient-controlled sedation
- Where
- Malaysia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Cholecystolithiasis
Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI)
Laparoscopic Cholecystectomy applied to Artificial pneumoperitoneum and the extent of Surgical stimulation cause the wave of hemodynamics increase vigorously, which make it difficult to judge the depth of anesthesia according to…
- Trial name
- DLTCI (NCT02116985)
- Testing
- Dual-loop TCI, manual
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Sedation
Target-controlled Infusion Versus Patient-controlled Sedation With Propofol in Endoscopic Retrograde Cholangiopancreatography (ERCP)
Propofol is a drug of choice for deep sedation in endoscopy. Propofol can be administered in many ways: by infusion or intravenous boluses and with self-administration device (patient-controlled sedation; PCS).
- Trial name
- NCT01072435
- Testing
- Patient-controlled sedation, Target-controlled infusion
- Where
- Finland
- Volunteers
- 82 people
- Sponsor
- Helsinki University Central Hospital
General Anesthesia, Hemodynamic Instability
Target-controlled Infusion Anesthesia and Post-induction Hypotension
Hemodynamic changes during induction of anesthesia may have adverse outcomes and should therefore be avoided. The decrease in blood pressure during induction of anesthesia with propofol is due to a decrease in systemic vascular…
- Trial name
- NCT05708638
- Testing
- Manual anesthesia induction, Anesthesia induction with Target controlled infusions (TCI)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Anesthesia Awareness
Entropy and Surgical Pleth Index Guided Closed Loop Target Controlled Infusion Total Intravenous Anesthesia With Propofol
Closed-loop infusion system for target controlled infusion of propofol by using TCI pump designed by BD Technology. (Germany) guided with entropy and surgical pleth index (GE) will not only prevent awareness from Anesthesia but…
- Trial name
- Closedloop TCI (NCT03773588)
- Testing
- Closed-Loop propofol Target controlled infusion by Entropy and SPI, Open-loop propofol target controlled infusion
- Where
- India
- Volunteers
- 40 people
- Sponsor
- KVG Medical College and Hospital
Hypoxemia
Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy
Alfentanil (Alf) is used in combination with Propofol (Pro) in fiber-bronchoscopy and in many other conscious sedation procedures.
- Trial name
- NCT01470170
- Testing
- Alfentanil, Normal saline, Targeted controlled infusion
- Where
- Taiwan
- Volunteers
- 173 people
- Sponsor
- Chang Gung Memorial Hospital
Anesthesia Brain Monitor, Sufentanil
Effects of Sufentanil Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet.
- Conditions
- Anesthesia Brain Monitor, Sufentanil, Target Controlled Infusion
- Trial name
- NCT06388408
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
Antimicrobial Treatment
Target-controlled Infusion Model for Cefepime
For this study, a previously developed population pharmacokinetic (popPK) model for cefepime (Jonckheere et al., submitted to JAC) was programmed in Rugloop vII, which is a software program to drive an infusion pump.
- Trial name
- NCT02688582
- Testing
- TCI group
- Volunteers
- 21 people
- Sponsor
- Onze Lieve Vrouw Hospital
Stroke, Ischemic, Stroke/Brain Attack
Manually Controlled Infusion Vs Target Controlled Infusion for StrokeThrombectomy
The goal of this randomized controlled trial is to compare manual general anesthesia induction to general anesthesia induction guided by target controlled infusion system in cerebral ischemic stroke The main questions it aims to…
- Conditions
- Stroke, Ischemic, Stroke/Brain Attack, Anesthesia, Hemodynamic Instability
- Trial name
- HASTE (NCT05570682)
- Testing
- TCI, Manual induction
- Where
- Italy
- Sponsor
- University of Padova
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Anesthesia Depth Monitoring, Analgesia Assessment
Target-Controlled Infusion (TCI) Effectiveness in Hysteroscopy
This prospective, randomized, observational study aims to evaluate the perioperative anesthetic efficacy of different Target-Controlled Infusion (TCI) models-specifically Minto, Schnider, and Eleveld pharmacokinetic models-in…
- Conditions
- Anesthesia Depth Monitoring, Analgesia Assessment, Perioperative Safety and Recovery, Target Controlled İnfusion
- Trial name
- NCT07023263
- Testing
- Schnider+ Mİnto, Eleveld
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Gazi University
Morbid Obesity
Remifentanil Dosing Regimes for Anesthesia in Bariatric Surgery: Characteristics of Early Recovery
Early recovery characteristics are important for patients' safety and operating room turnover. Our aim was to compare fundamental methods for dosing remifentanil during morbid obesity surgeries: a manual infusion and a…
- Trial name
- NCT04690088
- Where
- Lithuania
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Spine Diseases
Awakening in Spine Surgery: A Comparison Between Clinical Signs and Bispectral Index
BIS is one of several equipments used to monitor depth of anesthesia.Some studies found BIS can reduce total propofol dose when being used with target controlled infusion (TCI).The objective is to compare awakening time after…
- Trial name
- NCT02174913
- Testing
- bispectral index, Target controlled infusion of propofol, Fentanyl
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Mahidol University
Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted
Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)
This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS).
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted, Postoperative Recovery, General Anesthesia
- Trial name
- TCI-INHALE (NCT07288099)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Procedural Pain
To Explore the Optimal Dose of Dexmedetomidine for Skull Pin Fixation in Intracranial Surgery
Skull pin fixation is commonly used in intracranial surgery, which can increase the surgical field of view. Because skull pin fixation is a very irritating and painful medical treatment, it often results in tachycardia (>150-160…
- Trial name
- NCT06837818
- Testing
- Dexmedetomidine
- Volunteers
- 40 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hepatocellular Carcinoma
HAIC Combined With Second-line "Target Immunity" for HCC With TACE Standard Treatment Low Response or Failure
This study is a prospective, randomized controlled, multicenter clinical study. The purpose of this study is to explore the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) combined with second-line regorafenib…
- Trial name
- NCT05233358
- Testing
- Hepatic Artery Infusion Chemotherapy, Transarterial Chemoembolization, Regorafenib
- Volunteers
- 176 people
- Sponsor
- The Central Hospital of Lishui City