Clinical trials: Target Organ Damage
Hypertension, Ventricular Remodeling
Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Patients With Slight Hypertension and Target Organ Damage
Patients with slight increase in blood pressure levels have an increased cardiovascular risk. In particular this has been demonstrated also in subjects with high-normal blood pressure in whom an exaggerated blood pressure…
- Conditions
- Hypertension, Ventricular Remodeling, Erectile Dysfunctions
- Trial name
- NCT00687206
- Testing
- Valsartan 160mg plus HCT 25mg
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Hypertension
Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women
This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched…
- Trial name
- NCT03432468
- Testing
- Valsartan 1, Valsartan 80 mg
- Volunteers
- 102 people
- Sponsor
- LanZhou University
Hypertension
Effects of Potassium Salts on Blood Pressure and Target Organ Damage
The purpose of this study is to determine the effect of potassium chloride and potassium bicarbonate on blood pressure and also to determine whether increasing potassium intake has beneficial effects on the surrogate markers of…
- Trial name
- NCT00160368
- Testing
- Potassium supplementation
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- St George's, University of London
Resistant Hypertensive Patients
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
The ENSURE study is a multi-center, prospective, single-blind, randomized, controlled study of the effect of renal denervation on arterial stiffness and haemodynamics in subjects with uncontrolled hypertension.
- Trial name
- ENSURE (NCT02102126)
- Testing
- Renal denervation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 10th People's Hospital
Coarctation of the Aorta
Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension
The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta.
- Trial name
- NCT07134621
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Hypertension
Renal Denervation for Complicated Hypertension
This is an observational proof of concept study investigating the safety and effectiveness of renal denervation to lower blood pressure in people whose blood pressure is not adequately controlled due to: intolerance to…
- Trial name
- RDNP-2012-03 (NCT01865253)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- Baker Heart and Diabetes Institute
Hypertension
Sham Controlled Clinical Trial of Renal Denervation in Patients With Resistant Hypertension
The purpose of this study is to assess the efficacy of catheter-based renal denervation in reducing blood pressure in patients with resistant hypertension compared to a sham procedure.
- Trial name
- NCT02444442
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 105 people
- Sponsor
- Baker Heart and Diabetes Institute
Hypertension
Target Organ Damage and Polymorphisms Vav-2 and Vav-3 in Hypertensive Subjects
Objectives: To analyze the influence on the presence of target organ damage renal, cardiac and vascular of peripheral and central blood pressure, retinal vessels caliber, oxidative stress and polymorphisms of genes VAV-2-3 in…
- Trial name
- LOD-HTA (NCT02022618)
- Where
- Spain
- Volunteers
- 454 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Diabetes, Cardiovascular Disease
Relationship of Central Blood Pressure and Pulse Wave Velocity With Target Organ Damage
Diabetic patients show an increased prevalence of non dipping arterial pressure pattern, target organ damage and elevated arterial stiffness. These alterations are associated with increased cardiovascular risk.
- Trial name
- LOD-DIABETES (NCT01065155)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Hypertension
Spironolactone Versus Indapamide in Obese and Hypertensive Patients
Most recent guidelines continue to recommend thiazide diuretics as first-line agents for patients with hypertension in spite of the potential metabolic side effects, while mineralocorticoid receptor antagonists (MRAs), such as…
- Trial name
- NCT03626506
- Testing
- Spironolactone, Indapamide, Amlodipine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Hypertension
Korean Registry of Target Organ Damages in Hypertension
The objective of this study is to know prevalence of clinical or subclinical target organ damages in Korea hypertensives by constructing nationwide hypertension registry.
- Trial name
- KorHR (NCT01861080)
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Dongtan Sacred Heart Hospital
Malignant Hypertension
Determinants of Malignant Hypertension Onset and Related Target Organ Damages: the HAMA Biobank
The HAMA bank is an initiative aimed at collecting, preparing, and storing biological samples from patients treated for malignant hypertension and included in the HAMA cohort.
- Trial name
- HAMABANK (NCT06629363)
- Testing
- biobank
- Where
- 11 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier de PAU
Blood Pressure, Cardiovascular Risk Factor
Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population
This study is a sub-investigation of SAFAR study. Consecutive patients with established hypertension (treated or untreated with antihypertensive drugs) or with suspected hypertension are recruited and their 24-hour brachial and…
- Conditions
- Blood Pressure, Cardiovascular Risk Factor, Target Organ Damage, Cardiovascular Events
- Trial name
- SAFAR-China (NCT03154203)
- Testing
- No intervention in this study
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Hypertension
Salt Reduction on Blood Pressure and Cardiovascular Organ Damage
The purpose of this study is to determine the effect of a modest reduction in salt intake on blood pressure in white, black and Asian individuals with hypertension or prehypertension, and also to determine whether a modest…
- Trial name
- NCT00152074
- Testing
- Reduce salt intake
- Where
- United Kingdom
- Volunteers
- 210 people
- Sponsor
- St George's, University of London
Nocturnal Hypertension
Evaluation of Nocturnal Hypertension and Correlation With Target-Organ Damage
The aim of this study is to evaluate nocturnal hypertension with 24-hour ambulatory blood pressure and home blood pressure (BP) measurements through a) comparison of mean BP and nocturnal dipping assessed with the two methods, b)…
- Trial name
- NCT01533584
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Hypertension
The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence…
- Trial name
- NCT03451747
- Volunteers
- 322 people
- Sponsor
- LanZhou University
Hypertension
Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage
This study aims to determine whether dietary inorganic nitrate (in beetroot juice) is able to reduce overall thickening of the heart (left ventricular hypertrophy or LVH) and stiffness of the arteries when given to patients with…
- Trial name
- NITRATE-TOD (NCT03088514)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 149 people
- Sponsor
- Queen Mary University of London
Hypertension
The Chinese Early-onset Hypertension Study (CHESS)
Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult…
- Trial name
- CHESS (NCT02819674)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Abdominal Obesity, Hypertension
The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension
Obesity is a major risk factor for the development of hypertension. Based on population studies, risk estimates indicate that at least two-thirds of the prevalence of hypertension can be directly attributed to obesity.
- Trial name
- NCT01360710
- Testing
- Moxonidine, Irbesartan
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Baker Heart and Diabetes Institute