Clinical trials: Target Organs Damage
Hypertension
Spironolactone Versus Indapamide in Obese and Hypertensive Patients
Most recent guidelines continue to recommend thiazide diuretics as first-line agents for patients with hypertension in spite of the potential metabolic side effects, while mineralocorticoid receptor antagonists (MRAs), such as…
- Trial name
- NCT03626506
- Testing
- Spironolactone, Indapamide, Amlodipine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Coarctation of the Aorta
Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension
The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta.
- Trial name
- NCT07134621
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Obesity, Cardiovascular Risk Factors
The Impact of Obesity on Children and Adolescents.
The aim of the study is to investigate the association of obesity with arterial blood pressure, atherosclerosis, target organ damage (heart, arteries, kidney) and insulin resistance in children and young adolescents.
- Trial name
- NCT01231152
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- University of Athens
Hypertension
Korean Registry of Target Organ Damages in Hypertension
The objective of this study is to know prevalence of clinical or subclinical target organ damages in Korea hypertensives by constructing nationwide hypertension registry.
- Trial name
- KorHR (NCT01861080)
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Dongtan Sacred Heart Hospital
Hypertension, Hypertension (HTN)
Common Carotid Artery-Renal Artery-Femoral Artery Survey for Hypertension
To evaluate both sides of the common carotid artery, renal artery, and femoral artery in Hypertension patient that cause of systemic arterial hypertension and/or the effects of target organ damage, both structural and functional…
- Conditions
- Hypertension, Hypertension (HTN), Artery Disease, Target Organ Damage
- Trial name
- CRF Survey (NCT07760623)
- Testing
- Diameter measurement, Velocity
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- DejthidaNathaphong
Abdominal Obesity, Hypertension
The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension
Obesity is a major risk factor for the development of hypertension. Based on population studies, risk estimates indicate that at least two-thirds of the prevalence of hypertension can be directly attributed to obesity.
- Trial name
- NCT01360710
- Testing
- Moxonidine, Irbesartan
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Baker Heart and Diabetes Institute
Healthy, Hypertension
Central Blood Pressure in Adolescents and Young Adults
This study aims to investigate in adolescents and young adults: the 24h diurnal variation of ambulatory central blood pressure the association of central compared to peripheral blood pressure with indices of asymptomatic…
- Trial name
- NCT02222077
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Athens
Resistant Hypertensive Patients
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
The ENSURE study is a multi-center, prospective, single-blind, randomized, controlled study of the effect of renal denervation on arterial stiffness and haemodynamics in subjects with uncontrolled hypertension.
- Trial name
- ENSURE (NCT02102126)
- Testing
- Renal denervation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 10th People's Hospital
Hypertension
Japan Morning Surge-1 Study
The purpose of this study is to examine whether strict blood pressure (BP) control by doxazosin using home BP monitoring, especially targeting the morning BP level, can reduce hypertensive target organ damage.
- Trial name
- NCT00285519
- Testing
- Doxazosin (drug)
- Where
- Japan
- Volunteers
- 600 people
- Sponsor
- Japan Heart Foundation
Hypertension
Renal Denervation for Uncontrolled Hypertension
This is a study investigating the safety and usefulness of the Renal Denervation Procedure in reducing high blood pressure in people whose blood pressure is not adequately controlled despite already being treated with 2 blood…
- Trial name
- RDNP-2012-02 (NCT02016573)
- Testing
- Renal Denervation
- Sponsor
- Baker Heart and Diabetes Institute
Essential Hypertension
Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension
Resistant hypertension is defined as hypertension not controlled (i.e. blood pressure not below 140/90 mmHg) with the use of adequate doses of at least three different anti-hypertensives including a diuretic.
- Trial name
- NCT00138944
- Testing
- eplerenone
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Arterial Hypertension
Cumulative Blood Pressure Load and Left Ventricular Mass
Delay in the diagnosis of systemic arterial hypertension (SAH) causes morbid hypertensive status with target organ damage (TOD).
- Trial name
- NCT05465746
- Testing
- 24-hour ambulatory blood pressure monitoring (ABPM), Three-dimensional transthoracic echocardiography
- Where
- Ecuador
- Volunteers
- 80 people
- Sponsor
- Instituto Ecuatoriano del Corazón
Diabetes, Cardiovascular Disease
Relationship of Central Blood Pressure and Pulse Wave Velocity With Target Organ Damage
Diabetic patients show an increased prevalence of non dipping arterial pressure pattern, target organ damage and elevated arterial stiffness. These alterations are associated with increased cardiovascular risk.
- Trial name
- LOD-DIABETES (NCT01065155)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Cardiovascular Risk Factor
Automatic Image Analyzer to Assess Retinal Vessel Caliber
The objective of this work is the development and validation (reliability and validity) of the Automatic image analyzer to assess it retinal vessel caliber (ALTAIR) platform to analyze and validate its utility in different…
- Trial name
- ALTAIR (NCT02087605)
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension, Target Organ Damage
GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry
The goal of the GlycOxiTOD observational registry is to improve the early detection and characterization of vascular and other target-organ damage in adults at increased cardiovascular risk.
- Conditions
- Hypertension, Target Organ Damage, Heart Disease Risk Factors, Vascular Stiffness
- Trial name
- GlycOxiTOD (NCT06325800)
- Testing
- Multimodal Cardiovascular Phenotyping
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Complejo Hospitalario Universitario de Santiago
Nocturnal Hypertension
Evaluation of Nocturnal Hypertension and Correlation With Target-Organ Damage
The aim of this study is to evaluate nocturnal hypertension with 24-hour ambulatory blood pressure and home blood pressure (BP) measurements through a) comparison of mean BP and nocturnal dipping assessed with the two methods, b)…
- Trial name
- NCT01533584
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Chronic Kidney Disease, Hypertension
Assessment of Blood Pressure Control and Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension -II
The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with…
- Trial name
- NCT02078115
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Malignant Hypertension
Determinants of Malignant Hypertension Onset and Related Target Organ Damages: the HAMA Biobank
The HAMA bank is an initiative aimed at collecting, preparing, and storing biological samples from patients treated for malignant hypertension and included in the HAMA cohort.
- Trial name
- HAMABANK (NCT06629363)
- Testing
- biobank
- Where
- 11 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier de PAU
SLE, and Organ Damage Index
The 2019 EULAR/ACR Classification Criteria as Predictor of Organ Damage in Systemic Lupus Erythematosus Patients
The goal of this observational study is to investigate if the 2019 EULAR/ACR classification criteria can be used to assess organ damage in patients with systemic lupus erythematosus (SLE) and as predictor for prognosis .
- Trial name
- NCT06313151
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University