Clinical trials: Tear Disorder
Shoulder Dislocation
Results of Rotator Cuff Repair
The primary objective of this research is to examine the result of rotator cuff repairs following acute shoulder dislocations and to investigate whether timing of surgery following acute shoulder dislocations affects patients…
- Trial name
- NCT01549912
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pelvic Floor Disorders, Pelvic Floor; Perineal Rupture, Obstetric
The Effect of a Postpartum Training Program on Women Who Have Suffered a Levator Ani Injury.
The goal of this pilot randomized pilot controlled trial (RTC)is to collect acceptability and feasibility outcomes of a physiotherapy individualized program in women with levator injury that is intended to be used in a larger…
- Conditions
- Pelvic Floor Disorders, Pelvic Floor; Perineal Rupture, Obstetric, Physiotherapy
- Trial name
- NCT05617092
- Testing
- Physiotherapy treatment
- Where
- Sweden
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Rotator Cuff Tear
Rotator Cuff Repair Using Standard Double Row Technique With Platelet Rich Fibrin Membrane vs. Standard Double Row Technique
This study is a single-blind, randomized study evaluating the 6 month and 2 year outcomes of patients treated with arthroscopic rotator cuff repair using one of two techniques.
- Trial name
- RCRPRFM (NCT02256891)
- Testing
- PRFM, Double Row
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Premature Rupture of Membrane, Induction of Labor Affected Fetus / Newborn
PROMMO Trial: Oral Misoprostol vs IV Oxytocin
This is a prospective, randomized trial looking at the ideal method of labor induction for women with prelabor rupture of membranes and an unfavorable cervical Bishop score.
- Trial name
- PROMMO (NCT04478942)
- Testing
- Misoprostol Oral Product, Intravenous Oxytocin
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Migraine, Cluster Headache
Pain Biomarker Study
This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1.
- Conditions
- Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua
- Trial name
- PBS (NCT03511846)
- Testing
- Oral capsaicin, Topical capsaicin, Intranasal capsaicin
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Premature Rupture of Membrane
Magnesium Sulphate in Premature Rupture of Membranes
To assess the outcome of using magnesium sulphate on fetus and women with preterm premature rupture of membranes
- Trial name
- NCT05134688
- Testing
- Magnesium sulfate
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Assiut University
Lipid Tear Deficiency (Disorder), Dry Eye Disease
Changes in Tear Lipid Layer Thickness After Short Exposure to Light Emitting Diode Displays
Video display terminals (VDTs) are ubiquitous, and engagement in digital screens has grown substantially across all age groups worldwide. Prolonged exposure to VDTs is associated with the development of various health problems.
- Trial name
- NCT05003128
- Testing
- LED screen (InnoLux, Taiwan)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Dry Eye Disease
Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time
The purpose of the study is to observe lacrimal fluid condition (tear film break-up time) chronologically after a single dose of AL-43546 ophthalmic products（0.15%, 0.25% and vehicle）and 0.1% sodium hyaluronate ophthalmic…
- Trial name
- NCT00760045
- Testing
- Hydroxypropyl Guar Galactomannan, 0.1% sodium hyaluronate ophthalmic solution
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Syndromes
The Effect of Punctal Plugs on Tear Volume and Osmolality
The purpose of this study is to evaluate the role of tear volume in discomfort and dryness sensations during contact lens wear, and the possible influence on osmolality and ocular surface sensitivity.
- Trial name
- NCT00372034
- Testing
- Temporary Collagen Inserts
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Healthy, Dry Eye
Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers
The purpose of this study was to determine the safety and retention times of two different lengths (10 mm and 20 mm) of the MINI MONOKA canicular stent when inserted in the eye for up to three months in subjects with or without…
- Trial name
- NCT00743249
- Testing
- MINI MONOKA canalicular stent, 10 mm, MINI MONOKA canalicular stent, 20 mm
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Partial Rotator Cuff Tears (PRCTs)
High-frequency Short-course Extracorporeal Shock Wave Therapy for Partial Rotator Cuff Tears: Study Protocol for a Multicenter, Randomized, Controlled Trial
This is a multicenter, randomized controlled clinical study exploring three different extracorporeal shock wave therapy (ESWT) regimens for patients with partial rotator cuff tears, a common cause of chronic shoulder pain and…
- Trial name
- NCT07673055
- Testing
- Arm 1 Intervention Name: High-frequency short-course extracorporeal shock wave therapy Arm 2 Intervention Name: High-frequency intensive extracorporeal shock wave therapy Arm 3 Intervention Name: Conv
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Vitamin D Deficiency, Rotator Cuff Tears
Vitamin D3 Supplementation for Vitamin D Deficiency in Rotator Cuff Repair Surgery
Rotator cuff injuries are the most common cause of shoulder disability and is increasingly more prevalent in the aging population.
- Trial name
- NCT05009498
- Testing
- Vitamin D3 supplementation
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Community Memorial Health System
Breast Cancer
Clinical Trial to Evaluate the Safety and Efficacy of Breast Implant
The aim of this study is to evaluate the safety and efficacy of Cohesive Silicone Gel-Filled Breast Implant (CoSBI) produced by HansBiomed co.,Ltd. in breast reconstruction or augmentation
- Trial name
- NCT01711710
- Testing
- Cohesive Gel Breast Implant
- Where
- 2 sites in South Korea
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury
Use of the Modified Beef Tongue Model for Teaching Repair of Obstetrical Fourth-Degree Laceration to Residents
This is a study evaluating the use of the modified beef tongue model for teaching repair of obstetrical fourth-degree laceration to residents.
- Conditions
- Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury, Obstetric Labor Complications
- Trial name
- NCT03341351
- Testing
- Instructional video, Instructional workshop
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Dry Eye Syndromes, Cataract
Metabolomic Profile in Dry Eye Syndrome Patients.
The primary objective is to determine possible implications of deviant tear film quality for optimal refractive precision in patients scheduled for cataract surgery.
- Trial name
- NCT05433428
- Testing
- Lubricant Eye Drops, Preservative Free, Preservative
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ifocus Oyeklinikk
Dry Eye
Tear Layer Lipid Thickness in Pterygium Patient Before and After Surgery
The investigators study aims to capture the objective effects of pterygium surgery on tear layer lipid thickness and the tear layer.
- Trial name
- NCT02160769
- Where
- Singapore
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Dry Eye Syndromes
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).
This study will evaluate and compare 2 artificial tears in their ability to reduce post LASIK dry eye signs and symptoms. The secondary endpoint of this study is to evaluate refractive regression in these patients.
- Trial name
- NCT00620893
- Testing
- PEG- 400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Dry Eye Disease, Iron
A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.
This study aims to see if the amount of iron in tears is linked to how severe dry eye disease is. We hope this can lead to a new way to help diagnose and understand dry eye. This is an observational study.
- Trial name
- NCT07363824
- Testing
- Diagnostic tear fluid collection and ocular surface evaluation
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Dry Eye
Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects
Evaluation of the optical effects of Systane Ultra
- Trial name
- NCT01086774
- Testing
- Systane Ultra Lubricant Eye Drops
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alcon Research