Clinical trials: Telomere
FATTY LIVER, NO MALIGNANCY
Telomere Parameters in Patients With Nonalcoholic Fatty Liver
Telomerase, through its regulatory function on telomere length may play an important role in immune function, cellular replicative life span, and carcinogenesis.
- Conditions
- FATTY LIVER, NO MALIGNANCY, NO DECOMPENSATED ILLNESS
- Trial name
- telomereFL (NCT01694342)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Telomeres
EFFECTS OF RejuvaMatrix ™ ON TELOMERES
Lying for 30 to 60 minutes daily in a field of 75 decibels of electromagnetic energy at 54 to 78 GHz will allow telomeres of white blood cells to regenerate
- Trial name
- NCT04048044
- Testing
- Exposure to GHz electromagnetic energy (RejuvaMatrix)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Holos Institutes of Health, Inc
Bipolar 1 Disorder, Control Subjects
Socio-cognitive and Biological Responses to Maltreatment
The study will investigate how a history of emotional childhood maltreatment (CM) is associated with different aspects of psychological (social behaviour, empathy) and biological (brain function and structure, inflammation)…
- Trial name
- NCT07101107
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
General Anesthesia
The Association Between Telomere Length and Propofol Dose in Anesthesia-induction
Telomeres are protein-bound DNA repeat structures at the end of eukaryotic chromosomes that are made up of a simple repetitive sequence (in humans, TTAGGG) and regulate cellular replicative capacity and cellular proliferation…
- Trial name
- NCT03429309
- Testing
- Propofol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Core Temperature, Telomere Length, Mean Leukocyte
Mitigating Heat Stress Among Rickshaw Drivers in Bangladesh
The goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. Investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign…
- Conditions
- Core Temperature, Telomere Length, Mean Leukocyte, Kidney Function Issue
- Trial name
- NCT06956430
- Testing
- Battery-powered rickshaw
- Volunteers
- 300 people
- Sponsor
- University of California, Berkeley
Parent Child Relationship, Child Social-Emotional Development
The Impact of an Evidence-Based Parenting Service on Maternal Sensitivity and Infant Cellular Aging in a Population of Under-Resourced Families
The goal of this clinical trial study is to learn how stress in childhood, or Early Life Adversity (ELA), gets "under the skin" and influences long-term health.
- Conditions
- Parent Child Relationship, Child Social-Emotional Development, Telomere Length, Epigenetic Aging
- Trial name
- NCT06740266
- Testing
- Promoting First Relationships in Primary Care (PFR-PC)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Telomere Shortening, Aging
TA-65 and Aging Associated Microvascular Dysfunction
The goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (TA-65) improves microvascular function.
- Conditions
- Telomere Shortening, Aging, Vascular Diseases
- Trial name
- NCT05598359
- Testing
- TA-65
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Inherited Bone Marrow Failure Syndrome, Fanconi Anemia
Enhancing the Clinical Management of CMF Through a National Pediatric and Adult Network Based on Biological and Genetic Data
A non-profit, translational, prospective and retrospective study. Patients will be enrolled according to the procedures described in the protocol, and samples will be processed and analyzed as specified in the protocol.
- Conditions
- Inherited Bone Marrow Failure Syndrome, Fanconi Anemia, Dyskeratosis Congenita, Telomere Biology Disorder
- Trial name
- 2023-12377081 (NCT07877727)
- Where
- 4 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Istituto Giannina Gaslini
Meditation
Pilot Study to Evaluate the Effect of Transcendental Meditation on Telomere Activity and Well-Being Among Nurse Managers
The objective of this study is to evaluate the impact of a health and coping strategy (Transcendental Meditation, or TM) on Telomere Length and Telomerase Activity (known markers of physiological and psychological stress and…
- Trial name
- NCT07165795
- Testing
- Transcendental Meditation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sarasota Memorial Health Care System
Celiac Disease
Telomeres Parameters in Celiac Disease
Celiac disease is an autoimmune process that causes destructive changes in the epithel of the small bowel and it is also a pre-malignant state (e.g lymphoma).
- Trial name
- NCT02126033
- Testing
- take blood samples
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Obesity
Study of the Life Expectancy of Patients With Metabolic Syndrome After Weight Loss:
Background and study aims: Surgical and non-surgical normalization of body weight with obesity leads to a significant improvement in health and regression of metabolic syndrome.
- Trial name
- LIFEXPE-RT (NCT03667469)
- Testing
- Laparoscopic one anastomosis gastric bypass, Hypocaloric diet therapy
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- University Medical Center, Kazakhstan
Postoperative Cognitive Dysfunction
Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
- Trial name
- NCT03703973
- Testing
- Neuropsychology test
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Mucin B5 rs (35705950) Gene Polymorphism in Interstitial Lung Diseases
MucinB5 Gene Polymorphism and Leucocytes Telomere Length in Interstitial Lung Diseases
This is an observertional study aimed at Study the association between Mucin B5 rs (35705950) gene polymorphism and Leucocytes telomere length in relation to interstitial lung diseases.
- Trial name
- NCT06498141
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Psychological Stress, DNA Degradation, Apoptotic
CBART: The Reduction of Psychological and Physiological Stress in Women Undergoing IVF
The study is a randomized controlled trial of a cognitive behavioral interventions and an art-based stress reduction treatment protocol (CB-ART) with 100 women, identified with elevated perceived stress, before undergoing IVF…
- Conditions
- Psychological Stress, DNA Degradation, Apoptotic, Telomere Shortening, Fertility Disorders
- Trial name
- NCT03459053
- Testing
- CBART
- Where
- Israel
- Volunteers
- 88 people
- Sponsor
- University of Haifa
Anxiety Disorders, Social Anxiety Disorder
Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder
This study evaluates underlying psychological and biological mediators in Internet-delivered cognitive behavior therapy for adults with social anxiety disorder.
- Trial name
- UMEII (NCT02592564)
- Testing
- Internet-delivered cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Linkoeping University
OVARIAN STIMULATION, Telomere Length
Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?
Gonal-F® (follitropin alfa) is a recombinant FSH without LH activity, while Menopur® contains both LH and hCG. The MEGASET trial compared Menopur® and Gonal-F® in GnRH antagonist cycles with SET, showing similar efficacy.
- Conditions
- OVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte
- Trial name
- rFSH and hMG (NCT06732843)
- Where
- United Arab Emirates
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Frailty, Telomere
A Study of the Correlation Between the Debilitating State of the Elderly and Propofol Sensitivity
In an aging society, there is a surge in the number of surgeries for elderly patients in hospitals, and the elderly are at greater risk of anesthesia due to their own characteristics: slowing metabolism, decreasing resistance…
- Trial name
- NCT06870357
- Testing
- propofol
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Second Hospital of Shanxi Medical University
Telomere Biology Disorders, Dyskeratosis Congenita
Nucleoside Therapy in Patients With Telomere Biology Disorders
The goal of this clinical trial is to learn if a combination therapy of deoxycytidine (dC) plus deoxythymidine (dT) is safe in patients with telomere biology disorders.
- Conditions
- Telomere Biology Disorders, Dyskeratosis Congenita, Revesz Syndrome, Hoyeraal Hreidarsson Syndrome
- Trial name
- NCT06817590
- Testing
- deoxycytidine, deoxythymidine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Suneet Agarwal
Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)
Occupational and Environmental Exposures Analysis in Interstitial Lung Diseases.
The OCEAN-ILD study is designed to prospectively evaluate the prevalence and clinical relevance of environmental and occupational exposures in a large Italian cohort of patients affected by any ILD, using a standardised exposure…
- Conditions
- Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder), Exposure Occupational, Occupational Exposure
- Trial name
- OCEAN-ILD (NCT07577115)
- Testing
- standard interview
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Istituto Clinico Humanitas
Coronary Disease
Red Wine and Ageing and Atherosclerosis
The investigators will evaluate 100 regular red wine consumer men and 100 abstainers men from 50 years-old to 70 years-old by coronary risk prevalence, mood status, anthropometric measures, daily caloric ingest, lipid profile…
- Trial name
- NCT01268254
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo