Clinical trials: Telomere Disease
Heart Failure
Aerobic Exercise and Telomere Length in Patients With Heart Failure.
The present study will analyze and compare the chronic effects of aerobic exercise in subjects with systolic heart failure on telomere length.
- Trial name
- NCT03856736
- Testing
- MIAT, Control
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Male Infertility
The Impact of Lifestyle on Sperm Telomere Length and Telomerase Activity in Men Undergoing IVF Treatments
This aim of this study is to determine the impact of lifestyle on telomere length and telomerase enzyme activity on sperm cells of men undergoing IVF treatments.
- Trial name
- NCT04158765
- Testing
- DNeasy Tissue Kit (QIAGEN Inc., Mississauga, Ontario, Canada) and PCR- based assay (TRAPeze Telomerase Detection Kit; Millipore, Billerica, MA).
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Schizophrenia, Physical Activity
Physical Exercise in Patients With Schizophrenia
Randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the Salamanca University Assistance Complex and who will be randomly…
- Conditions
- Schizophrenia, Physical Activity, Telomere Shortening, Premature Aging
- Trial name
- NCT05978921
- Testing
- Strength physical exercise programme, Normal life
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
Pulmonary Fibrosis
Telomeres Length in Israeli Fibrotic ILD Patients
Individuals with fibrotic interstitial lung diseases (FILD) will be recruited after providing informed consent. in addition to routine data as usually collected in the clinic, blood samples will be taken for measurement of…
- Trial name
- NCT06885515
- Testing
- leukocyte telomere length (LTL) will be measured using the Telomere Restriction Fragment (TRF) Analysis method
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Dyskeratosis Congenita, Telomere Biology Disorders
Needs Assessment for Individuals and Families Affected by Dyskeratosis Congenita (DC) and Related Telomere Biology Disorders (TBD)
Background: DC and related TBDs are a group of illnesses caused by variants in genes that regulate telomeres. These illnesses can cause problems with the skin and mucous membranes.
- Trial name
- NCT04959188
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Fibrosis, Telomere Shortening
The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis
TELO-SCOPE is a national, multi-centre, double-blind, placebo-controlled, randomised (2:1) trial which will test the hypothesis that, compared to placebo, the addition of danazol to standard of care in pulmonary fibrosis…
- Conditions
- Pulmonary Fibrosis, Telomere Shortening, Telomere Disease, Dyskeratosis Congenita
- Trial name
- NCT04638517
- Testing
- Danazol
- Where
- 9 sites in Australia
- Volunteers
- 29 people
- Sponsor
- The University of Queensland
Primary Immune Deficiency Disorder, Immune Deficiency Disease
Regenerative Medicine to Restore Hematopoiesis and Immune Function in Immunodeficiencies and Inherited Bone Marrow Failures
Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune…
- Conditions
- Primary Immune Deficiency Disorder, Immune Deficiency Disease, Bone Marrow Failure, Short Telomere Length
- Trial name
- NCT04232085
- Testing
- Alemtuzumab, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acute Kidney Injury, Heart Valve Diseases
Telomere Biology and AKI in Cardiac Surgery
The purpose of this study is to investigate whether biomarkers of cell senescence and aging can predict the development of acute kidney injury following cardiac surgery.
- Conditions
- Acute Kidney Injury, Heart Valve Diseases, Coronary Artery Disease
- Trial name
- NCT02692833
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 254 people
- Sponsor
- Queen Mary University of London
Prostate Cancer
Telomere Associated Variables (TAVs) in Prostate Cancer
This research project results from the interest in continuing the collaboration with the previous LL-HURS-ONC001 clinical validation study, which gives cause to the present study.
- Trial name
- NCT04124900
- Where
- 10 sites in United States, Spain
- Volunteers
- 509 people
- Sponsor
- Life Length SL
Telomere Length, Quality of Life
Subtle Energy Transmission and Tao Calligraphy Mindfulness in Telomere Length in Peripheral Blood Leukocytes
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Telomere Length in Peripheral Blood Leukocytes A Follow-up Pilot Study The goal of this Pilot clinical trial is to learn if a Subtle Energy…
- Trial name
- NCT06357663
- Testing
- Mindfulness practice with Calligraphy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Sha Research Foundation
Food Addiction
Differences in Length of Telomere in Food Addicted vs Non Food Addicted Persons
The purpose of this descriptive study is to examine telomere length between two groups of people, those with and those without food addiction and identify possible relationships that may play a role in food addiction, it's…
- Trial name
- NCT05649189
- Testing
- telomere length measure
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Nebraska
Alzheimer Disease
Telomerase Activator and Retinal Amyloid
A method of detecting amyloid in the retina has been developed. A specially designed retinal camera will directly visualze and record retinal amyloid and via image processing will generate a number: the retinal amyloid index…
- Trial name
- NCT02530255
- Testing
- cycloastragenol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chippewa Valley Eye Clinic
Aging, Skin Laxity
Association of Leucocyte Telomere Length With DPAS Score in Skin Aging
The goal is to know the profile of photoaging based on clinical examination, Dermoscopic Photoaging Scale and leucocyte telomere length The main questions of Research are: what is the profile of photoaging based on clinical…
- Trial name
- NCT06501547
- Testing
- Leucocyte Telomere Length from blood draw
- Where
- 3 sites in Indonesia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Sperm Preservation, Irradiated Semen
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and…
- Trial name
- NCT04715828
- Testing
- Cryopreserved semen, Acute and low irradiation, Long and low irradiation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Aging, Obesity
Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters
The study will involve 80 elderly women, 40 eutrophic and 40 obese, divided into four groups, each with n=20. 1) Eutrophic Group (EG) undergoing only nutritional counseling (NC), 2) Eutrophic Group with NC and combined training…
- Conditions
- Aging, Obesity, Nutrition, Exercise
- Trial name
- NCT07479940
- Testing
- Combined Training, Nutritional Counseling
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Lung Cancer (Diagnosis), Health Adult Subjects
Prospective Multicentre Study for the Application of Telomere Measurement Technology as a Tool for Lung Cancer Diagnosis
This research is a clinical performance study of in vitro diagnostic device (IVD), a prospective, multicentre, open-label, case-control clinical investigation aimed at constructing a predictive model that allows results to be…
- Conditions
- Lung Cancer (Diagnosis), Health Adult Subjects, Patient
- Trial name
- PneumoTAV001 (NCT07465848)
- Testing
- Blood sample collection for telomere biomarker analysis, Telomere biomarker analysis
- Where
- 12 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Grupo Español de Investigación en Diagnóstico y Tratamiento Hipertemprano de Enfermedades (GeDiTPhe)
Telomere Shortening, Telomere Length, Mean Leukocyte
Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy
Constitutional mutations of genes involved in telomere repair and maintenance are responsible for "telomeropathy" (" Congenital Dyskeratosis "). Attrition of telomeres promotes cell senescence and genetic instability.
- Trial name
- ANDROTELO (NCT03710356)
- Testing
- Danazol 200 MG
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Telomere Disease
Low-Dose Danazol for the Treatment of Telomere Related Diseases
Background: DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA.
- Trial name
- NCT03312400
- Testing
- Danazol
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Disease, Telomere Shortening
Telomere Length in Relation to Acute Stress Response in Critical Care Patients
the investigators studied the impact of severe stress (in this case any event or illness leading to a necessity of critical care) on telomere length.
- Trial name
- NCT03982589
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Prostate Cancer, Aging Disorder
Influence of Prostate Cancer Radiation on Aging
Previous studies have reported that cancer survivors develop age-related chronic conditions like frailty, sarcopenia, cardiac dysfunction, and cognitive impairment earlier and/or at a greater burden than similarly aged…
- Conditions
- Prostate Cancer, Aging Disorder, Radiotherapy; Complications, Inflammation
- Trial name
- NCT04321187
- Where
- Austria
- Volunteers
- 314 people
- Sponsor
- Medical University of Graz