Clinical trials: Termination of Pregnancy
Pregnancy, Polycystic Ovary Syndrome
Metformin to Prevent Late Miscarriage and Preterm Delivery in Women With Polycystic Ovary Syndrome
The overall aim of the PregMet 2 Study is to investigate whether metformin prevents late miscarriages and preterm deliveries in PCOS women treated with metformin from first trimester of pregnancy to delivery in a large…
- Trial name
- PregMet2 (NCT01587378)
- Testing
- Metformin
- Where
- 13 sites in Iceland, Norway and 1 more
- Volunteers
- 489 people
- Sponsor
- Norwegian University of Science and Technology
Medical; Abortion, Fetus
Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion
Background and Rationale Abortion accounts for about 8% of maternal mortality worldwide. Surgical intervention is the definitive treatment for abortion but it is invasive.
- Trial name
- NCT04194658
- Testing
- Letrozole 2.5mg
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Letrozole, Misoprostol
Letrozole Plus Misoprostol Versus Misoprostol Only in Induction of Missed Abortion
This study aimed to evaluate the effect of letrozole plus misoprostol to terminate non-viable pregnancies in first trimester compared with the use of misoprostol alone.
- Conditions
- Letrozole, Misoprostol, Induction, Missed Abortion
- Trial name
- NCT07636317
- Testing
- Letrozole + Misoprostol, Misoprostol
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Sohag University
Pregnancy, Unplanned
Use of an Algorithm to Determine IV Sedation Dosing During First-trimester Surgical Abortion
This study aims to compare an algorithm for IV sedation dosing to the current standard of care in patients undergoing first trimester surgical abortion.
- Trial name
- NCT01994317
- Testing
- Algorithm, Standard care
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Induced Abortion
Expansion Study of a Simplified Regimen of Medical Abortion Thru 63 Last Menstrual Period (LMP) in Tunisia
This open-label study is being conducted to determine whether national expansion of a 400 mcg of sublingual misoprostol (i.e., under the tongue) taken 24 hours following administration of mifepristone 200 mg is effective and…
- Trial name
- NCT01173003
- Testing
- Mifepristone, misoprostol
- Where
- Tunisia
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Recurrent Abortion
Sildenafil Citrate and Recurrent Abortion
Two groups of unexplained recurrent spontaneous abortion, each included 65 participants. scheduled randomly into; the study group received Sildenafil Citrate and Placebo group.
- Trial name
- NCT03475160
- Testing
- Sildenafil Citrate vaginal suppositories, Uterine artery Doppler before treatment, Uterine artery Doppler after treatment
- Volunteers
- 130 people
- Sponsor
- Benha University
Abortion, Induced
Cervical Priming Before Dilation & Evacuation
The purpose of this study is to compare the efficacy of buccal misoprostol cervical priming to laminaria priming among women undergoing D\&E at 13-20 weeks gestation in the Western Cape Province, South Africa
- Trial name
- NCT01597726
- Testing
- Misoprostol, Laminaria
- Where
- South Africa
- Volunteers
- 159 people
- Sponsor
- Ibis Reproductive Health
Contraception
Study of Immediate Start of Progestin Contraceptives in Medical Abortion
This study will compare immediate to post-abortion start of two progestin-based contraceptives (DMPA and etonorgestrel implants) among women having first trimester medical abortion who wish to use that method for post-abortion…
- Trial name
- Quickstart (NCT01902485)
- Testing
- Timing of Contraceptive Initiation in Medical Abortion
- Where
- 8 sites in United States, Mexico
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Second Trimester Abortion
Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion
Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion - a Double Blinded Randomized Controlled Trial
- Trial name
- NCT03044093
- Testing
- Mifepristone, Misoprostol
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Pneumonia, Pleural Effusion
Evaluation of Ultra-portable Ultrasound in General Practice
This is an interventional multi-centre study comparing two groups of general practitioners with or without an ultrasound scanner over a period of 6 months.
- Conditions
- Pneumonia, Pleural Effusion, Renal Colic, Hepatic Colic or Cholecystitis
- Trial name
- EPEMedG (NCT04127149)
- Testing
- Ultrasound scan
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Hospices Civils de Lyon
Pregnancy Complications, Legally Induced Abortion Without Mention of Complication
Medical Abortion up to 10 Weeks Gestation at Home
Medical abortion performed in the womens home has shown to be safe and acceptable up to 9 weeks of gestation. Our project is aiming to confirm our hypothesis that it is equally effective, safe and acceptable when the gestation is…
- Trial name
- NCT02191774
- Testing
- Medical abortion at home
- Where
- Sweden
- Volunteers
- 273 people
- Sponsor
- Karolinska Institutet
Violence, Domestic
Adaptation and Testing of the Addressing Reproductive Coercion in HEalth Settings (ARCHES) Intervention in Bangladesh
The primary purpose of this research is to conduct a brief project to adapt and evaluate an evidence-based intervention model to address reproductive coercion and unintended pregnancy (ARCHES - Addressing Reproductive Coercion…
- Trial name
- ARCHES (NCT03539315)
- Testing
- ARCHES
- Where
- 6 sites in Bangladesh
- Volunteers
- 2,729 people, healthy volunteers welcome
- Sponsor
- Ipas
Chronic Endometritis
Efficacy of Dead Sea Peloid Gel in Chronic Endometritis
This study evaluates the effect of Dead Sea Peloid Gel in the treatment of Chronic Endometritis in women with reproductive disorders.
- Trial name
- NCT02680275
- Testing
- Dead Sea Peloid Gel
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Scientific Center for Family Health and Human Reproduction Problems, Russia
Abortion
Evaluation of of a Prefixed 50% N2O- 50%O2 Mixture in Legal Abortion Under Local Analgesia
To evaluate effectiveness of a prefixed 50% N2O- 50%O2 mixture in legal abortion under paracervical block.
- Trial name
- NCT00769912
- Testing
- 50% N2O- 50%O2 mixture
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spontaneous Abortion, Missed Abortion
Dilation and Curettage Versus Operative Hysteroscopy for Missed Abortion
Randomizedtrial comparing success and complication rates of operative hysteroscopy versus traditional dilation and curettage (D\&C) in the management of first trimester missed abortion.
- Conditions
- Spontaneous Abortion, Missed Abortion, Intrauterine Adhesion, Retained Products of Conception
- Trial name
- NCT04705324
- Testing
- Operative Hysteroscopy, D&C, Operative Hysteroscopy - safety and feasibility
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Abortion; Attempted, Medical
Feasibility of a Self-performed Urinary Test for the Follow-up on Medical Abortion
This study was a national, longitudinal, prospective, observational survey, carried out in metropolitan France, with a sampling of 21 birth control centres.
- Trial name
- NCT02304835
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Nordic Pharma SAS
Pregnancy Termination
Comparing Two Regimens for Medical Abortion: Mifepristone+Misoprostol Versus Misoprostol Alone
A double blinded, placebo-controlled randomized trial to compare the safety, efficacy and acceptability of two medical abortion regimens up to 63 days' LMP.
- Trial name
- NCT00680394
- Testing
- mifepristone, misoprostol
- Where
- 2 sites in Tunisia, Vietnam
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy Complicated by Low Implantation
Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial
Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept.
- Trial name
- ILRIFRM (NCT01679561)
- Testing
- intralipid
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Pregnancy, Pregestational Diabetes
Safety of Metformin in Pregnancy
This study aims to better characterize the risk linked to metformin use during pregnancy, using a prospective multicentric cohort design enabling a large sample size, in evaluating the rate of birth defects after first trimester…
- Conditions
- Pregnancy, Pregestational Diabetes, Polycystic Ovary Syndrom
- Trial name
- NCT02793505
- Testing
- metformin, any drug not known as a major teratogen or major fetotoxicant
- Volunteers
- 950 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Abortion
Comparative Psychiatric Problems Between First and Second Trimester Miscarriage
Description of the psychiatric impact of miscarriage on women.
- Trial name
- NCT06742632
- Testing
- Symptoms checklist-90
- Where
- Egypt
- Volunteers
- 155 people
- Sponsor
- Assiut University