Clinical trials: The Frailty Syndrome
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Frailty Syndrome, Aging
Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)
This is a Phase I, open-label, non-randomized clinical trial to evaluate the safety and preliminary efficacy of adipose-derived mesenchymal stem cell secretome capsules (VinVital) in patients with frailty syndrome.
- Trial name
- VinVital (NCT07856602)
- Testing
- VinVital
- Volunteers
- 20 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Frail Elderly Syndrome, Postoperative Delirium
Different Frailty Scores to Incidence of Post-operative Delirium and Cognitive Dysfunction
Patients who are frail will have higher rate for post-operative morbidities, mortality, prolonged hospital stays, loss of independence, increase in institutionalization, post-operative cognitive dysfunction (POCD) and delirium…
- Conditions
- Frail Elderly Syndrome, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT04056871
- Testing
- Frailty Screening Tools
- Where
- Malaysia
- Volunteers
- 400 people
- Sponsor
- University of Malaya
Cognitive Frailty
Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome
The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome…
- Trial name
- PCDS (NCT07335978)
- Testing
- Intervention 1
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Atma Jaya Catholic University of Indonesia
Metabolic Syndrome, Aging
Sustainable Exercise and Nutrition Programs for Managing Metabolic Disorders in Older Women
This study aims to evaluate the impact of sustainable diet and exercise programs on metabolic health and quality of life in older women.
- Conditions
- Metabolic Syndrome, Aging, Sarcopenia, Obesity
- Trial name
- NCT07015307
- Testing
- Sustainable Diet Program, Supervised Physical Exercise Program, Combined Sustainable Diet and Exercise Program
- Where
- Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Frail Elderly Syndrome
Frailty and Surgery
Frailty has been recently re-defined as a condition that is evident over time through an excess of vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event, and occurrence of…
- Trial name
- NCT05594277
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
The Frailty Syndrome
Ghrelin Dose Finding In Frail Elderly
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty.
- Trial name
- NCT01605435
- Testing
- Ghrelin Group 1, Ghrelin Group 2
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Frailty, Geriatric Syndromes
Beneficial Effects of an Integrated Program of Multicomponent Physical Exercise. Cohort Study
The study has been designed to analyze the possible positive effects of a multicomponent physical exercise program monitored with an integrated electronic device system in dwelling-community frailty older adults.
- Conditions
- Frailty, Geriatric Syndromes, Functional Recovery
- Trial name
- Ros-Ita (NCT04711785)
- Testing
- Multicomponent exercise program
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital de la Ribera
ACS, Frail Elderly Syndrome
The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome
This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital.
- Conditions
- ACS, Frail Elderly Syndrome, Elderly Patient
- Trial name
- NCT04580706
- Testing
- this is an observational study with none intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Friendship Hospital
Frailty Syndrome
Validation of the Screening Instrument: PRISMA-7 for Frailty Among Elderly Hospitalized Danes
The questionnaire PRISMA-7 was originally developed to assess frailty in community dwelling adults. The questionnaire was translated into the Danish language.
- Trial name
- NCT03999047
- Testing
- PRISMA score
- Where
- Denmark
- Volunteers
- 1,050 people
- Sponsor
- Region Zealand
Frailty, Caregiver Burden
The Effect of Health Promotion Comprehensive Education Intervention on the Frailty Levels of Elderly Family Caregivers
This study was conducted to evaluate the effect of a comprehensive health promotion educational intervention applied to family caregivers over the age of 60 on their fragility levels.
- Conditions
- Frailty, Caregiver Burden, Frail Elderly Syndrome
- Trial name
- NCT06064227
- Testing
- training intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Fatma Banu Demirdas
Frail Elderly Syndrome, Transitional Care
Models of Care in the Transition From the Secondary to the Primary Sector Among the Frailest Elderly
In most Western countries the elderly population increases rapidly. In Denmark, the population of elderly aged 75 years or older may amount to nearly 15 % of the entire population in 2050 compared to 9 % today (2017).
- Conditions
- Frail Elderly Syndrome, Transitional Care, Frailty, Readmission
- Trial name
- NCT03796923
- Testing
- Early follow-up visit after discharge, Comprehensive geriatric assessment (CGA), Continued geriatric care
- Where
- Denmark
- Volunteers
- 3,340 people
- Sponsor
- University of Aarhus
Frailty Syndrome
Analysis of Frailty Syndrome Within the Framework of the Innovation Fund Project PRÄP-GO (ANA-PRÄP-GO)
The patients included in PRÄP-GO and the corresponding comparison cohorts will be offered to participate in this complementary study in order to be able to carry out a detailed characterization and phenotyping of the frailty…
- Trial name
- NCT04880824
- Testing
- Prehabilitation- new form of care
- Where
- 27 sites in Germany
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Malnutrition Elderly, Sarcopenia in Elderly
A Nutrition Care Model for Frailty Prevention in the Elderly Based on Design Thinking
This international multicenter study project. A physical function screening activity for the elderly will be held in the community centers.
- Conditions
- Malnutrition Elderly, Sarcopenia in Elderly, Frailty Syndrome
- Trial name
- NCT07504419
- Testing
- nutrition education
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suh-Ching, Yang
Frailty Syndrome, Caregiver Burden for Those Who Care for Adults With Impaired Functional Status
Real World Evidence to Assess the Value of a Digital Care Coordination and Monitoring Program for Supporting Caregivers of Adults Discharged From the Emergency Department.
The RW-HOMECARE study is a prospective, longitudinal, real-world pilot trial designed to assess the impact of proposing the Monka digital solution to non-professional caregivers of patients discharged from emergency or short-stay…
- Trial name
- RW-HOMECARE (NCT07348081)
- Testing
- Caregivers supporting vulnerable patients and using the MyMonka solution.
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Frail Elderly Syndrome
A Study of the Intervention Effect of a Hybrid Exercise Program on Frail Elderly
The declining physical condition of frail elderly is becoming an ugent problem. Although the exercise intensity of Wu Qin Xi appears to be low, it is highly effective in the older individuals.
- Trial name
- NCT05832853
- Testing
- Wu Qin Xi exercise, Wu Qin Xi, resistance training and endurance training, Resistance training and endurance training
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Guang Yang, Prof. Dr.
Frailty Syndrome, Surgery--Complications
Pre-frailty and Rehospitalization in Cardiac Surgery
Background: It has been demonstrated that pre-frailty has more adverse outcomes after cardiac surgery, however, data on prognosis and long-term evolution in pre-frailty patients after cardiac surgery without postoperative…
- Conditions
- Frailty Syndrome, Surgery--Complications, Coronary Artery Disease, Valve Anomalies
- Trial name
- NCT03949439
- Testing
- Elective Cardiac Surgery
- Where
- Brazil
- Volunteers
- 453 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Frailty, Frailty Syndrome
Frailty Screening in the Swedish Emergency Department Setting
This prospective observational study will investigate the correlation of frailty in relation to serious outcomes. Serious outcomes are defined as: mortality within 30 days, admission to hospital, length of stay in the Emergency…
- Conditions
- Frailty, Frailty Syndrome, Emergency Department, Geriatric Assessment
- Trial name
- NCT04877028
- Where
- Sweden
- Volunteers
- 1,800 people
- Sponsor
- University Hospital, Linkoeping
Frailty, Frail Elderly Syndrome
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population.
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging
- Trial name
- NADage (NCT06208527)
- Testing
- Nicotinamide Riboside (NR)
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Frail Elderly Syndrome
Protocols and Guidelines for the Use of Digital Twins in Frail Older People
The Proto-Aging study aims to define experimental protocols and guidelines to enable the development of musculoskeletal models (digital twins) of elderly people, with the ultimate goal to comprehensively characterize frail elders…
- Trial name
- Proto-Aging (NCT05854316)
- Testing
- Comprehensive Biomechanical assessment
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli