Clinical trials: Therapy Failure
Heart Failure, Self Care
Effect and Cost Effectiveness of a Dyadic Empowerment-based Heart Failure Management Program for Self-care
Global population aging has drastically increased healthcare spending worldwide, with the greatest portion going to hospital and community health services.
- Conditions
- Heart Failure, Self Care, Empowerment, Transitional Care
- Trial name
- NCT05806606
- Testing
- Dyadic empowerment based heart failure management program, Dyadic education program
- Where
- Hong Kong
- Volunteers
- 232 people
- Sponsor
- The University of Hong Kong
Heart Failure
Optimization of CRT Using an ECG Vest
Despite advancements in implant technology and various techniques of optimization, there is still around 30% non-responder rate to cardiac resynchronization therapy (CRT).
- Trial name
- NCT02699944
- Testing
- ECG Vest Optimization
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Alan J. Bank, MD
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Cardiac Neuromodulation for Heart Failure
This investigation will evaluate the ability of the Moderato® System to safely and effectively deliver CNT, to reduce sympathetic activity in heart failure patients
- Trial name
- NCT04573699
- Testing
- CNT-HF
- Where
- Poland
- Volunteers
- 34 people
- Sponsor
- BackBeat Medical Inc
End-stage Renal Disease, Renal Replacement Therapy
Renal Replacement Therapies Decision Aids
Different renal replacement therapy methods will cause significant impacts on the physical, mental, and social for patients with end-stage renal disease.
- Conditions
- End-stage Renal Disease, Renal Replacement Therapy, Decision Aid, Decision-making
- Trial name
- NCT05666544
- Testing
- Web-based patient decision aid, Written health education leaflets
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- China Medical University Hospital
Acute Hypoxemic Respiratory Failure
Benefits of Optiflow® Device for Preoxygenation Before Intubation in Acute Hypoxemic Respiratory Failure : The PREOXYFLOW Study
Oro-tracheal intubation in intensive unit care(ICU) in acute hypoxemic respiratory failure after crash induction remains a critical event.
- Trial name
- PREOXYFLOW (NCT01747109)
- Testing
- PREOXYFLOW, STANDARD FACE MASK
- Where
- 6 sites in France
- Volunteers
- 122 people
- Sponsor
- Nantes University Hospital
End Stage Renal Disease, Hepatitis C
Renal Transplants in Hepatitis C Negative Recipients With Nucleic Acid Positive Donors
In this study, individuals without hepatitis C infection who are on the kidney transplant waitlist will receive a kidney from a deceased donor with hepatitis C infection and will be treated for hepatitis C at the same time.
- Trial name
- NCT03627299
- Testing
- 300mg glecaprevir/pibrentasivir 120mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Acute Respiratory Failure
Treatment of Critical Illness Polyneuromyopathy
Acute respiratory failure is a heterogeneous disorder that results in more than 300,000 Americans requiring admission to an intensive care unit for invasive mechanical ventilatory support each year.
- Trial name
- Do-It-Now (NCT01058421)
- Testing
- intensive physical therapy, control group
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Aplastic Anemia
Romiplostim N01 in Chemoradiotherapy-induced Aplastic Anemia
This study aimed to explore the efficacy and safety of romiplostim N01 in the treatment of chemoradiotherapy-induced aplastic anemia (AA)
- Trial name
- NCT07572084
- Testing
- Romiplostim N01
- Volunteers
- 43 people
- Sponsor
- Peking Union Medical College Hospital
Heart Failure With Reduced Ejection Fraction
EHR Nudges to Improve Quality of Care in HF
The purpose of this pilot feasibility study is to test a pharmacist-facing clinical decision support tool designed to increase adherence to guideline-directed medical therapy and evaluate the tool using the Reach, Effectiveness…
- Trial name
- NCT06103565
- Testing
- Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Hematologic Malignancies, Inborn Errors of Metabolism Disorders
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
The objective of this study is to make T-cell depleted stem cells from a family member who is a half match (haplo-identical) available on an expanded access basis to patients receiving one or two unrelated cord blood transplants…
- Conditions
- Hematologic Malignancies, Inborn Errors of Metabolism Disorders, Immune Deficiencies
- Trial name
- NCT01881334
- Testing
- CliniMACS CD34 Reagent System
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Acute on Chronic Liver Failure (ACLF)
Very Low-volume Plasma Exchange in ACLF
This is a prospective, multicenter, open-label, non-inferiority, randomized controlled trial evaluating the efficacy and safety of very low plasma exchange (400 mL plasma + prothrombin complex concentrate) and plasma-free…
- Trial name
- VLPE-ACLF (NCT07857434)
- Testing
- Double Plasma Molecular Adsorption System (DPMAS), Low-volume plasma exchange, Prothrombin Complex Concentrate (PCC)
- Volunteers
- 840 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Permanent Atrial Fibrillation
Atrioventricular Junction Ablation and Biventricular Pacing for Atrial Fibrillation and Heart Failure
There is evidence of superiority of AV junction ablation strategy over pharmacological therapy only for symptoms of atrial fibrillation, but not for heart failure, hospitalization, morbidity and mortality.
- Trial name
- APAF-CRT (NCT02137187)
- Testing
- AV junction ablation, CRT, Optimized drug therapy
- Where
- Italy
- Volunteers
- 1,830 people
- Sponsor
- Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella
Adherence, Treatment
High-Flow in Hypercapnic Stable COPD Patients
Monocentric, prospective, open, randomized 1:1, controlled study to evaluate the impact of nasal high-flow (NHF) on nocturnal transcutaneous PCO2 (PtCO2) compared to non-invasive ventilation ± Long-Term Oxygen Therapy (LTOT) in…
- Trial name
- HIGH-FLOW (NCT04281316)
- Testing
- Nasal High Flow installation, Non Invasive Ventilation, Training session
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Growth Hormone Deficiency, Endocrine System Diseases
A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency
A 38-week dosing trial of lonapegsomatropin, a long-acting growth hormone product, administered once-a-week versus placebo-control.
- Conditions
- Growth Hormone Deficiency, Endocrine System Diseases, Hormone Deficiency
- Trial name
- foresiGHt (NCT04615273)
- Testing
- Lonapegsomatropin, Somatropin
- Where
- 113 sites in United States, Armenia and 22 more
- Volunteers
- 264 people
- Sponsor
- Ascendis Pharma Endocrinology Division A/S
HFpEF - Heart Failure With Preserved Ejection Fraction
Role of Colchicine as Anti-Inflammatory Therapy in HFpEF
Heart failure with preserved ejection fraction (HFpEF) is a condition associated with high morbidity and mortality. Chronic low-grade inflammation plays a key role in its progression, yet few treatments specifically target this…
- Trial name
- CO-HFpEF (NCT06837623)
- Testing
- Colchicine Tablets
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Heart Failure
Study to Improve the Treatment of Patients With Heart Failure by General Practitioners
The purpose of this study is to determine whether it is possible to improve the care of general practitioners for patients with heart failure.
- Trial name
- TOPHU (NCT01662323)
- Testing
- GP's treating HF according the dutch guidelines
- Volunteers
- 683 people
- Sponsor
- Julius Center
Heart Failure With Reduced Ejection Fraction
Immediate Release Versus Slow Release Carvedilol in Heart Failure
Assessment of clinical effect and treatment quality of immediate release carvedilol (IR) versus slow release carvedilol (SR) in patients with HFrEF
- Trial name
- SLOW-HF (NCT03209180)
- Testing
- CarVeDilol-SR (Slow Release), Carvedilol IR (Immediate Release)
- Where
- 13 sites in South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Bundang Hospital
Acute-on-Chronic Liver Failure (ACLF), hepatitisB
The Relationship Between Novel Virological Indicators and Treatment With Different Nucleotide Analogues and the Prognosis of HBV-ACLF Patients
This is an observational study. This study mainly explores the dynamic changes of HBV RNA and HBcrAg during the treatment of HBV-ACLF, as well as the safety of entecavir (ETV), tenofovir alafenamide (TAF) and tenofovir…
- Conditions
- Acute-on-Chronic Liver Failure (ACLF), hepatitisB, Treatment
- Trial name
- NCT07815418
- Where
- China
- Volunteers
- 235 people
- Sponsor
- Tongji Hospital
Amyloid Cardiomyopathy
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy
This Phase 1b/2a study aims to investigate the safety and efficacy of genistein in patients with Transthyretin (TTR) Amyloidosis.
- Trial name
- GASPAR (NCT06634108)
- Testing
- Genistein
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Liver Transplant; Complications, Cirrhosis
Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant
Liver transplantation is increasingly performed for older adults with multiple comorbidities. Medication adherence is key to maintaining proper function of the transplanted liver and optimize health; however, adhering to…
- Conditions
- Liver Transplant; Complications, Cirrhosis, End Stage Liver DIsease, Medication Adherence
- Trial name
- TEST (NCT05260268)
- Testing
- TEST Intervention
- Where
- 3 sites in United States
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania