Clinical trials: Therapy Strategies
Hypertension
Primary Care Strategies to Reduce High Blood Pressure: A Cluster Randomized Trial in Rural Bangladesh, Pakistan and Sri Lanka
Background: High blood pressure (BP) is the leading attributable risk for cardiovascular disease (CVD). In rural South Asia, hypertension remains to be a significant public health issue with sub-optimal rates of case finding and…
- Trial name
- COBRA-BPS (NCT02657746)
- Testing
- multi-component interventions
- Volunteers
- 2,550 people
- Sponsor
- Duke-NUS Graduate Medical School
ST-elevation Myocardial Infarction
The Short- and Long Term Outcomes of Early Routine PCI With the Standard Treatment in Low-intermediate Risk ST-elevation Myocardial Infarction Patients Who Successfully Fibrinolysis.
1. Objective: To evaluate short- and long-term in the STEMI patients who successfully thrombolysis with early routine and delay percutaneous coronary intervention in low-intermediate risk patients. 2.
- Trial name
- NCT02131103
- Testing
- Percutaneous coronary intervention
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Chiang Mai University
Cardiomyopathies
Risk Stratification and New Early Prevention and Treatment Strategies for Patients With Cardiomyopathy (STRENGTH）
This study will include patients with different types of cardiomyopathy from multiple centers were prospectively enrolled in a retrospective study to establish a natural population cohort of cardiomyopathy patients.
- Trial name
- NCT06352320
- Testing
- Diagnosis of HCM, Diagnosis of DCM, Diagnosis of ARVC
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
HIV/AIDS, Contraception
Pharmacologic Strategies for the Etonogestrel Implant in HIV-Infected Women
This study will evaluate the frequency of ovulation and cervical mucus quality of HIV-infected Ugandan women on efavirenz-based antiretroviral therapy using either a single etonogestrel implant or two etonogestrel implants for at…
- Trial name
- NCT03282799
- Testing
- etonogestrel implant
- Where
- Uganda
- Volunteers
- 72 people
- Sponsor
- Catherine Anne Chappell
Gaucher Disease
Advancing Integrated Therapies for Gaucher Disease
The purpose of this study is to better understand the natural history, clinical outcomes, and biological features of Gaucher disease in patients receiving standard medical care
- Trial name
- NCT07758816
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Acromegaly
Therapeutic Strategies in Acromegalic Subjects Treated With Lanreotide 120mg
The study aims to evaluate the biochemical and clinical effectiveness on symptoms and tumor size of a monotherapy with Lanreotide 120mg in acromegalic subjects, to describe criteria for starting alternative strategies, and to…
- Trial name
- ACRO-OPTIM (NCT02698384)
- Where
- 10 sites in France
- Volunteers
- 4 people
- Sponsor
- Ipsen
Human Immunodeficiency Virus (HIV)
Antiretroviral Treatment Strategies in Relation to Adherence, Resistance and Virological Treatment Failure
This project aims to assess different antiretroviral treatment strategies, optimally controlled and conventional, in relation to drug resistance and virological treatment failure.
- Trial name
- DotArv (NCT01433601)
- Testing
- Enhanced Treatment Support (ETS)
- Where
- Vietnam
- Volunteers
- 640 people
- Sponsor
- Karolinska Institutet
Head and Neck Squamous Cell Carcinoma
Multicentric Comparative Study Between a Conventional and an Intensive Follow up Strategy After Treatment of a Head and Neck Squamous Cell Carcinoma
Phase III randomized trial to compare the efficacy in terms of overall survival of two follow-up strategies (conventional versus intensive) among smokers and/or alcohol drinkers patients, older than 35 year, in complete remission…
- Trial name
- SURVEILL'ORL (NCT03519048)
- Testing
- Nasofibroscopy, Low Dose Chest CTscan, injected CT-scan
- Where
- France
- Volunteers
- 197 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Ovarian Cancer
The Effect of TRA-8 on Ovarian Cancer Tissue
The goal of this study is to determine the apoptosis-inducing efficacy of TRA-8 in patient ovarian cancer tissues using a tissue slice technology.
- Trial name
- NCT00711932
- Where
- United States
- Volunteers
- 478 people
- Sponsor
- University of Alabama at Birmingham
Severe Acute Respiratory Distress Syndrome / Severe ARDS, Invasive Mechanical Ventilation
Hemodynamic and Cardiac Effects of Individualized PEEP Titration Using Esophageal Pressure Measurements in ARDS Patients
The acute respiratory distress syndrome (ARDS) is common condition in critical ill patients affecting 7.2 people / 100,000 population / year and more than 7% of patients with invasive mechanical ventilation for more than 24…
- Conditions
- Severe Acute Respiratory Distress Syndrome / Severe ARDS, Invasive Mechanical Ventilation, Individualized PEEP Treatment Strategy
- Trial name
- ENCODE (NCT02617914)
- Testing
- individualized PEEP treatment, Invasive mechanical ventilation, ECMO,
- Sponsor
- RWTH Aachen University
Obesity, Weight Loss
Effectiveness of Integrative and Complementary Practice in Health as a Strategy in Obesity Treatment
Obesity is highlighted, pointed as a disease that has been increasingly affecting individuals and becoming an epidemic in recent decades, but auriculotherapy has been shown to contribute to the treatment of this disease.The…
- Trial name
- NCT04089384
- Testing
- Control Group, Auriculotherapy Group
- Volunteers
- 120 people
- Sponsor
- University of Pernambuco
Adenocarcinoma, Bronchiolo-Alveolar
Therapeutic Strategy in Advanced Bronchioloalveolar Carcinoma
To evaluate among patients with untreated advanced ADC-CBA, impact on the disease control rate after 4 months treatment of an early therapeutic permutation with the first month in the absence of stabilization or objective answer.
- Trial name
- NCT00384826
- Testing
- erlotinib, paclitaxel + carboplatine
- Where
- 9 sites in France
- Volunteers
- 133 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Prostate Cancer
Strategies to Improve Bone Health in Men on ADT
This is a phase II randomized controlled trial (RCT) of 2 strategies to improve bone health in men receiving androgen deprivation therapy (ADT).
- Trial name
- NCT02043236
- Testing
- Healthy bones pamphlet, Bone Health Care Coordinator, Letter to GP
- Where
- Canada
- Volunteers
- 159 people
- Sponsor
- University Health Network, Toronto
Juvenile Idiopathic Arthritis
Strategies Towards Personalised Treatment in Juvenile Idiopathic Arthritis (JIA).
Inhibitors of tumour necrosis factor (TNFa) reduce inflammation in patients with juvenile idiopathic arthritis (JIA), but only 20-40 percent achieve a state of no or very little disease activity.
- Trial name
- MyJIA (NCT04614311)
- Testing
- Triamcinolone Hexacetonide 20 MG/ML
- Where
- 5 sites in Norway
- Volunteers
- 189 people
- Sponsor
- Oslo University Hospital
Vasculitis, Wegener's Granulomatosis
Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years
The aim of this trial is to lower the morbidity rate in elderly patients affected with systemic necrotizing vasculitides, by reducing mortality and improving global outcome.
- Conditions
- Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis, Churg-Strauss Syndrome
- Trial name
- CORTAGE (NCT00307671)
- Testing
- prednisone, methylprednisolone,cyclophosphamides, Cyclophosphamide, Azathioprine,prednisone,methylprednisolone, Mycophenolate mofetil,methotrexate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis
Cladribine Tablets as an Exit Therapy Strategy
The objective of the study is to evaluate the effectiveness of CladT, in terms of disease stability and safety, as the last treatment option in ageing MS patients vs treatment continuation and discontinuation This observational…
- Conditions
- Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
- Trial name
- CLADREXIT (NCT06887426)
- Testing
- Cladribine
- Where
- France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Myocardial Infarction
FFR Versus Angiography-Guided Strategy for Management of AMI With Multivessel Disease
The aim of the study is to compare clinical outcomes following fractional flow reserve (FFR)-guided versus angiography only guided strategy in treatment of non-infarction related artery (non-IRA) stenosis in patients with acute…
- Trial name
- FRAME-AMI (NCT02715518)
- Testing
- PCI using 2nd generation drug-eluting stent
- Where
- South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Heart Failure
Medtronic South Asian Systolic Heart Failure Registry
The purpose of this study is to (a) characterize the current management of patients with systolic heart failure (HF) in South Asia following an educational intervention of current guidelines and delivery of disease management…
- Trial name
- SASHFR (NCT01434615)
- Testing
- CRT, No-CRT
- Where
- India
- Volunteers
- 502 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Acute Respiratory Distress Syndrome (ARDS)
Clinical Features, Treatments, and Outcomes in Acute Respiratory Distress Syndrome (ARDS-CTO)
The goal of this observational prospective cohort study is to explore the clinical characteristics, treatment strategies, and outcomes of adult patients with acute respiratory distress syndrome (ARDS) admitted to the medical…
- Trial name
- ARDS-CTO (NCT07186140)
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Jee Hwan Ahn
Patient With Sonographically Indeterminate or Complex Adnexal Mass
ADNEXMR Scoring System: Impact of an MR Scoring System on Therapeutic Strategy of Pelvic Adnexal Masses
Background : About 25% of adnexal masses remain indeterminate after transvaginal ultrasonography, as evidenced by the published literature.
- Trial name
- ASCORDIA01 (NCT02664597)
- Testing
- ADNEXMR Scoring System, Standard strategy
- Where
- France
- Volunteers
- 377 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.