Clinical trials: Therapy Strategies
Acute Myeloid Leukaemia (AML), Measurable Residual Disease (MRD)
Sorafenib Combined With Venetoclax as Pre-emptive Therapy Strategy for MRD+ AML: a Prospective, Single-arm, Multicenter Clinical Study
The purpose of this study is to explore the efficacy and safety of sorafenib combined with venetoclax as pre-emptive therapy strategy for measurable residual disease persisting acute myeloid leukemia.
- Trial name
- NCT07264010
- Testing
- Sorafenib (SORA), Venetoclax (VEN)
- Volunteers
- 87 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatitis C
Way to Cure HCV Adherence
This is a 3-arm, multi-center, patient-randomized, field evaluation of the "Way to Cure" behavioral interventions on medication adherence in HCV.
- Trial name
- WTC (NCT02472925)
- Testing
- MedSignals Pill Box
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Cryptococcal Meningitis
Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS
The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce morbidity and mortality due to AIDS…
- Trial name
- PreCASA (NCT02624453)
- Testing
- Fluconazole, Antiretroviral therapy
- Where
- Cameroon
- Volunteers
- 186 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Branch Atheromatous Disease
Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction
Perforating artery territorial infarction (PAI) refers to a single ischemic lesion in a single perforating arterial territory and branch atheromatous disease (BAD) is an important type.
- Trial name
- STRATEGY (NCT05310968)
- Testing
- Tirofiban hydrochloride sodium chloride injection, Aspirin
- Where
- 37 sites in China
- Volunteers
- 970 people
- Sponsor
- Beijing Tiantan Hospital
Urinary Incontinence in Children
Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)
The primary objective is to investigate if abrupt withdrawal versus gradual withdrawal of pharmacotherapy (solifenacin and/or mirabegron) influences the risk of recurrence of incontinence.
- Trial name
- NCT06465576
- Testing
- Solifenacin, Mirabegron, Solifenacin + Mirabegron
- Where
- 5 sites in Denmark
- Volunteers
- 216 people
- Sponsor
- University of Aarhus
HIV Infection, Hepatitis C
A Study Exploring an Induction-Maintenance Kaletra-Based Therapy Versus a Sustiva-Based Regimen in Previously Non-Treated, HIV-1/HCV Co-Infected Subjects
The purpose of this study is to determine whether a simplified lopinavir/ritonavir-based therapy will continue to keep the viral load at very low levels after initial treatment with a combination of Kaletra (lopinavir/ritonavir)…
- Trial name
- NCT00121017
- Testing
- Kaletra (lopinavir/ritonavir), Sustiva (efavirenz), Truvada (emtricitabine/tenofovir disoproxil fumarate)
- Volunteers
- 200 people
- Sponsor
- Abbott
Coronary Heart Disease
After Eighty Study
The rationale of the present clinical trial is to study whether an invasive strategy in clinical stable patients over 80 years with NSTEMI/UAP may improve rates of death, reinfarction, stroke, need of urgent revascularisation…
- Trial name
- NCT01255540
- Where
- Norway
- Volunteers
- 492 people
- Sponsor
- Oslo University Hospital
Language Difficulties in British Sign Language
Language Therapy in British Sign Language
In the United Kingdom, the language of the Deaf community is British Sign Language (BSL). A small proportion of Deaf young people who use BSL as their first or dominant language have specific language difficulties and would…
- Trial name
- NCT02579668
- Testing
- Language Therapy
- Volunteers
- 29 people
- Sponsor
- University College, London
Literacy
Occupational Therapy-based Literacy Intervention and Classroom Based Literacy Intervention
The purpose of this study is to determine the impact of a literacy focused occupational therapy intervention program versus standard classroom-based reading intervention on reading engagement and reading achievement in elementary…
- Trial name
- NCT03975972
- Testing
- Occupational Therapy Based Literacy Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Type 2
Insulin Glulisine in Type 2 Diabetic Patients
To evaluate the efficacy of a single injection of glulisine before the main meal added to insulin glargine plus oral antidiabetic drugs (OADs) compared to insulin glargine plus OADs in Type 2 diabetic patients poorly controlled…
- Trial name
- Basal Plus (NCT00360698)
- Testing
- Insulin Glargine, Glimepiride, Insulin Glulisine
- Where
- 3 sites in United States, Russia and 1 more
- Volunteers
- 106 people
- Sponsor
- Sanofi
Early-onset Sepsis
Promoting Optimal Treatment Choices in Neonates With Suspected Early-Onset Sepsis
In this study, three neonatal evidence-based antibiotic stewardship strategies will be implemented in Dutch hospitals. These include the early-onset sepsis (EOS) calculator, procalcitonin (PCT)-guided therapy, and IV-to-oral…
- Trial name
- PrOTeCt-NEO (NCT06845332)
- Where
- 11 sites in Netherlands
- Volunteers
- 55,000 people
- Sponsor
- Franciscus Gasthuis
Breast Cancer, Cancer
REaCT-vascular Access Her2 Negative Vascular Access Strategies for (Neo) Adjuvant Breast Cancer Treatment Without Trastuzumab
In the REaCT-Vascular Access Her2 negative study, the investigator will use a novel method to allow comparisons of established standard of care vascular access strategies using the "integrated consent model" as part of a…
- Trial name
- OTT 15-07 (NCT02688998)
- Testing
- venous access PORT or PICC
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Ottawa Hospital Research Institute
HIV Infections
Strategy-confirming Study of BMS-955176 to Treat HIV-1 Infected Treatment-experienced Adults
The purpose of this study is to evaluate whether the combination of BMS-955176 with atazanavir (ATV) [with or without ritonavir (RTV)] and dolutegravir (DTG) is efficacious, safe, and well-tolerated in HIV-1 infected treatment…
- Trial name
- NCT02386098
- Testing
- BMS-955176, Atazanavir (ATV), Ritonavir (RTV)
- Where
- 64 sites in United States, Argentina and 11 more
- Volunteers
- 86 people
- Sponsor
- ViiV Healthcare
Coronary Artery Disease, Aortic Atherosclerotic Disease
Evaluation of the Strategy of "One-stop" Endovascular Treatment for Concomitant Coronary Artery Disease and Aortic Atherosclerotic Disease
The study is a prospective, randomized, controlled, exploratory trail to evaluate the strategy of "one-stop" endovascular treatment for concomitant coronary artery disease and aortic atherosclerotic disease.
- Trial name
- NCT03563768
- Testing
- One-stop strategy group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Arthritis, Arthritis, Rheumatoid
An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis
The purpose of this study is to examine whether an magnetic resonance imaging (MRI) -guided treatment strategy based on a predefined treatment algorithm can prevent progression of erosive joint damage, increase remission rate and…
- Conditions
- Arthritis, Arthritis, Rheumatoid, Joint Diseases, Musculoskeletal Diseases
- Trial name
- IMAGINE-RA (NCT01656278)
- Testing
- Magnetic resonance imaging (MRI), Conventional biochemical and clinical examinations
- Where
- 9 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen
Ischemic Stroke
Functional Prognosis in Patients With Ischemic Stroke According to the Therapeutic Strategy Used
The current management of ischemic stroke is based on different strategies that may be combined: intravenous thrombolysis in a stroke ICU, intravenous thrombolysis in a telemedicine procedure, endovascular thrombectomy.
- Trial name
- PARADISE (NCT02856074)
- Testing
- prise de sang, quality of life questionnaire
- Where
- France
- Volunteers
- 821 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Esophageal Cancer
Palliative Radiotherapy and Brachytherapy for Oesophageal Cancer Dysphagia
Hypothesis: In the management of advanced oesophageal cancer, to determine if a shorter regime of external beam radiotherapy (using higher daily doses, and combined with intraluminal high dose rate brachytherapy) is not inferior…
- Trial name
- NCT00665197
- Testing
- Protracted Course Radiotherapy, Short Course Radiotherapy
- Where
- 7 sites in Canada, China and 5 more
- Volunteers
- 200 people
- Sponsor
- International Atomic Energy Agency
Huntington Disease
Clinical Study to Monitor Plasma Levels of 24OHC in Subject with HD
A 2-year clinical longitudinal study to measure plasma concentrations of 24S-hydroxycholesterol, a brain-derived cholesterol catabolite, in subjects with Huntington disease, from the presymptomatic to the symptomatic stages.
- Trial name
- Chol-HD (NCT04257513)
- Testing
- Brain MRI
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes
Postprandial meal glucose control with closed-loop systems (CLS) still needs some improvements. In the postprandial period, sensor delay in detecting blood glucose rise after a meal together with delays in insulin absorption…
- Trial name
- NCT02416765
- Testing
- 15-hour intervention, Insulin (Lispro, Aspart or guilisine), Glucagon (Eli Lilly)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Pituitary Adenoma
Efficiency and Safety of Different Treatment Strategies in Adults With Pituitary Adenomas With Hypothalamic Involvement
Prospective and randomized evaluate efficiency and safety of different treatment strategies for hypothalamus-invading pituitary adenomas (HIPA)
- Trial name
- NCT04863456
- Testing
- Total resection, Staged resection, Subtotal resection followed by stereotactic radiation therapy
- Volunteers
- 90 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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