Clinical trials: Therapy Strategies
Diabetes Mellitus, Type 2
Opposing Step-by-step Insulin Reinforcement to Intensified Strategy
Primary objectives : To show the non inferiority in terms of efficacy (HbA1c) of insulin glargine plus metformin combined with 1 to 3 bolus of insulin glulisine introduced progressively (Arm 2) compared with insulin glargine plus…
- Trial name
- OSIRIS (NCT00174642)
- Testing
- Insulin Glargine, Insulin Glulisine, Metformin
- Where
- 18 sites in Belgium, France and 16 more
- Volunteers
- 811 people
- Sponsor
- Sanofi
Chronic Pain
Evaluation of an Opioid Decrease Strategy in Chronic
Increase in the consumption of analgesics observed in many countries with a mediatic crisis resulting in an increasingly frequent wish of patients to wean themselves from opiates. A recent update (B.
- Trial name
- EODSCPP (NCT04424459)
- Testing
- opioid withdrawal
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Intraoperative Hypotension
PPI Guided Strategies for Prevention and Treatment of Intraoperative Hypotension
Intraoperative hypotension is closely related to the poor prognosis of surgery. The study is focused on the effectiveness of maintaining normal peripheral perfusion index (PPI) on time-weighted average of hypotension during…
- Trial name
- NCT05792696
- Testing
- PPI guided strategies, Empirical strategies
- Where
- China
- Volunteers
- 54 people
- Sponsor
- zhiqiang zhou
Neuromyelitis Optica, Autoimmune Diseases
Inectolizumab With Steroid Optimization in Newly Treated NMOSD
Title: Study of Inectolizumab Combined With Steroid Hormone Adjustment Strategies in Treatment-naive Patients With Neuromyelitis Optica Spectrum Disease Objective:This study aims to evaluate the steroid-sparing effect and safety…
- Conditions
- Neuromyelitis Optica, Autoimmune Diseases, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NCT07159893
- Testing
- Inebilizumab + Rapid Steroid Tapering group, Inebilizumab + Standard Steroid Tapering group
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Coronary Artery Disease
Optimal Antiplatelet and Lipid Therapy in ACS With DES: OPACT Trial
" Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) require optimized medical therapy to prevent recurrent cardiovascular events.
- Trial name
- NCT07432516
- Testing
- Discontinuation strategy + Combination lipid-lowering therapy, Switching strategy + Combination lipid-lowering therapy, Discontinuation strategy + High-intensity statin therapy
- Where
- South Korea
- Volunteers
- 4,400 people
- Sponsor
- Yonsei University
Implementation of a Chronic Disease Management Programme, COPD
Effects of an Active Implementation of a Guideline for Chronic Obstructive Pulmonary Disease
Aims: To design a proactive implementation strategy for a chronic-disease-management-programme. To describe effects of the active implementation of a programme for COPD-patients measured on patient-related goals and use of health…
- Trial name
- NCT01228708
- Testing
- Active implementation of a guideline for chronic disease
- Volunteers
- 3,021 people
- Sponsor
- University of Aarhus
Coronary Artery Disease
Smart Angioplasty Research Team-Optimal Strategy for Side Branch Stenting in Coronary Bifurcation Lesion With Drug-Coated Balloon
A prospective, multi-center, open-label, randomized controlled, superiority trial. The aim of the study is to compare clinical outcomes between upfront 2-stenting strategy versus upfront drug-coated balloon (DCB)-based hybrid…
- Trial name
- SMART-DCB (NCT07019350)
- Testing
- Upfront DCB-based hybrid strategy, Upfront 2-stenting strategy
- Where
- 3 sites in South Korea
- Volunteers
- 520 people
- Sponsor
- Samsung Medical Center
RRMS
Effectiveness of the Combination Strategy of Disease-Modifying Therapy and the Yishen Daluo Yin Modified Formula for Multiple Sclerosis
This study was designed to investigate the effectiveness of a combined strategy utilizing disease-modifying therapy and the modified Yishen Daluo Yin formula for relapsing-remitting multiple sclerosis (RRMS) through a…
- Trial name
- NCT07037823
- Testing
- Modified Yishen Daluo Yin formula
- Volunteers
- 328 people
- Sponsor
- Ying Gao
Hepatitis B, Chronic
Discontinuation of Antiviral Therapy as a Strategy to Cure Hepatitis B
Cirrhosis or cancer of the liver caused by hepatitis B virus (HBV) are major global health problems. Chronic HBV infection has become more common in Sweden with immigration.
- Trial name
- STOP-B (NCT05328427)
- Testing
- Stopping
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Göteborg University
Dysautonomia
MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters
The purpose of this research study is to better understand what causes dysautonomia and how this affects blood pressure and pulse. Dysautonomia is a condition of the autonomic nervous system.
- Trial name
- NCT01692561
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Chronic Pelvic Pain
CPP Among Somali Women in Norway: SCED
Chronic pelvic pain (CPP) in women is a condition associated with negative cognitive, behavioral, sexual and emotional consequences.
- Trial name
- NCT07820176
- Testing
- Multimodal physiotherapy
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Kristiania University College
Ventilation Therapy; Complications, Technical Skills
Educational Strategies for Maintaining Technical Skills in Neonatal Resuscitation for the Nursing Team
Despite efforts for initial training in neonatal resuscitation, health professionals show a decline in post-training skills, requiring continuing training.
- Conditions
- Ventilation Therapy; Complications, Technical Skills, Nurse's Role
- Trial name
- Neo-VPP (NCT06882018)
- Testing
- Repeated practice guided by peers, Instructor-guided deliberate practice
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ahmed Moussa
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Controlled Versus Standard Oxygen Therapy in ICU Patients With Acute Exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Acute exacerbations frequently require intensive care unit (ICU) admission.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD, Intensive Care Unit (ICU), Controlled Oxygen Therapy
- Trial name
- OXYCOPD-ICU (NCT07842510)
- Testing
- Controlled oxygen therapy, Standard oxygen therapy
- Where
- 2 sites in Tunisia
- Volunteers
- 240 people
- Sponsor
- Hôpital Universitaire Taher Sfar
Acute Coronary Syndrome
Acute Coronary Syndrome Genetic Study
To describe the role of genetic factors and its relationship and interaction with environmental factors in the recurrence of cardiac events in Chinese patients with acute coronary syndrome.
- Trial name
- NCT01964313
- Where
- China
- Volunteers
- 3,422 people
- Sponsor
- Peking University First Hospital
Hypertension
Study Evaluating the Efficacy of Nifedipine GITS - Telmisartan Combination in Blood Pressure Control.
Patients having uncontrolled or poorly controlled hypertension are at risk of experiencing cardiovascular events such as myocardial infarction or stroke.
- Trial name
- NCT00750113
- Testing
- Nifidipine, Telmisartan, Nifedipine/Telmisartan
- Where
- 43 sites in Italy, Spain
- Volunteers
- 405 people
- Sponsor
- Bayer
Mechanical Ventilation Pressure High, Critical Illness
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all.
- Trial name
- NCT06393179
- Testing
- pressure-volume curve with a low-flow insufflation of 5 L/min
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Acquired Brain Injury
Integrated PRocess and StrategieS Training: I-PRESS Training
There is a pressing need to develop more effective interventions to remediate cognitive deficits in highly prevalent disabling conditions such as stroke, head injury and other forms of acquired brain injury (ABI).
- Trial name
- I-PRESS (NCT04882215)
- Testing
- GMT combined with WMU Training
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- NHS Greater Glasgow and Clyde
Cataract
CAtaract ASSessment of IntrOcular Lens Objective PErformancE
Prospective, interventional, non-invasive, monocentric, longitudinal, non-randomized study
- Trial name
- CASSIOPEE (NCT06168617)
- Testing
- Performance tasks in daily life
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Renal Cell Cancer
WIRE - Novel Treatments in Renal Cell Cancer
Evaluation of proof of mechanism with relation to ktrans and/or CD8 count when different IMPs are given as monotherapy or as combination therapy.
- Trial name
- WIRE (NCT03741426)
- Testing
- Olaparib, Cediranib, Volrustomig
- Where
- 7 sites in United Kingdom
- Volunteers
- 134 people
- Sponsor
- CCTU- Cancer Theme
HIV Prevention, Pre-exposure Prophylaxis (PrEP)
A Study Evaluating An Integrated Pharmacy Digital Diary and Delivery Strategy to Increase PrEP Use Among MSM and TGW
The PrEP 3D randomized controlled trial (RCT) will study the effectiveness of the PrEP-3D app compared to standard of care for starting pre-exposure prophylaxis (PrEP), continuing PrEP, and adherence to PrEP.
- Conditions
- HIV Prevention, Pre-exposure Prophylaxis (PrEP), Risk Reduction, Adherence, Medication
- Trial name
- PrEP-3D RCT (NCT05474313)
- Testing
- PrEP-3D package, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
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